Meet the chemical that lets sea creatures thrive
...rface. Thehigh pressures can prevent proteins from folding up to form working enzymes, according to Paul Yanceyof Whitman College in Walla Walla, Washington. Unfolded proteins are covered with water molecules, butfor the protein molecule to fold up properly this water has to leave. "High pressure tends to tr...Seeing one weapon from a food-borne pathogen
...esidues, but areotherwise quite different in their folding topologies. "It seems that the bacteria got the e...or integrin binding, then put them into adifferent folding context." There are antibiotics available that can kill Y. pseudotuberculosis ,but Bjorkman and Is...Scientists image key steps in bacterial infection
...g of a new book onmacromolecular assembly, protein folding and host-pathogen interactions." FimH has two major regions, the images revealed. One interacts with chaperone,while the other -- which looks like a jelly roll -- latches onto a sugar calledmannose. In the body, mannose is attached to a receptor in t...Lab experiments reveal potential therapeutic target for degenerative brain diseases
... molecule from foldingincorrectly. Since abnormal folding is associated with prion disease, blockingthe ability of the prion protein to assume an abnormal shape could be key toblocking progression to disease. "Prion disease pathology requires misfolded prion proteins," comments NIAIDDirector Anthony ...Simulating protein folding from physical laws
...y have had their best successyet in simulating the folding of a protein solely from the physical laws thatgov...Todd Professor of Chemistry emeritus,simulated the folding of the protein HDEA from the bacterium E. coli onCornell's IBM supercomputer and predicted a struc......rms of cancer. Dr. Frydman's researchinto protein folding inside mammalian cells is viewed as some of the mostinnovative in the chaperone/protein folding arena. Partho Ghosh, Ph.D., University of California, San Diego Dr. Ghosh is a leading investigator...Study shows cognitive decline is not normal in aging
...tivities, and following simple directions, such as folding a piece ofpaper in half....Duke researchers discover protein that can alert immune system to fight cancer
... to have evolved a dualfunction: assisting protein folding inside the cell and alerting the immunesystem if they are released from the cell, as happens when tissue is underassault from inflammation, wounding or autoimmune attack. The discovery is described and explained in two papers in the June 1is...Target for cystic fibrosis drugs found
...lls of CF patients at the most basic level. It's a folding problem that might be familiar to any home-maker. ...also offer a new way to remedy it. Much like, when folding a big bed sheet, one little slip can turn the wholething into a misshapen mess, a similar thing happ...Stanford launches interdisciplinary initiative in the biological sciences
...challenging computationalproblems -such as protein folding and DNA sequencing- that are of interest toresearchers in computer science. In the longer term, Latombe adds, thebiosciences may inspire new computational schemes and architectures. In such an atmosphere, departmental divisions increasingly are a pro...Nonexponential rates support idea of protein folding 'funnel'
...ports an energylandscape "funnel" model of protein folding has been obtained by researchers atthe University ...of Illinois. The evidence -- highly nonexponential folding times -- was observed duringsub-millisecond folding experiments conducted on two proteins: yeastphos...Protein Misfolding, Not Mutant Gene, Key To Lethal Sleep Disorder
... normal function of which is not known. Theinitial folding error may be induced by a genetic mutation or may occurspontaneously. It then spreads via protein-to-protein contact, with themisshapen version somehow inducing normal proteins to take on the new,indigestible structure. The first SFI patient was a pr......alstructure. This transformation -- called protein folding - is one of the mostactive areas of molecular biological research, and has taken on even moreimportance with the growing knowledge that misfolding can lead to such disordersas Alzheimer's disease, Huntington's disease, and prion-relatedneurodegenerat...Protein Adultery Revealed!: Mechanism Of Protein Folding Captured In Computer Simulation
...ure the process of oneprotein interfering with the folding of another has been created at theDepartment of En...l leap The notorious complexity of simulating the folding of even a single protein, andthe lack of computational resources to do so, had inhibited researchers...Model Polymers Reveal New Clues to Protein Folding
... temperature andwatched it refold itself. For each folding sequence they separately tracked theposition of ea...ulations with model polymers of 64 and80 mers, the folding pathways also grouped themselves into separate classes ofintermediate states. These intermediate p...Leibniz Prize Winners 1999 - Most Highly Endowed German Promotional Prize For Ten Scientists
...uch as thermal shock which leads to faulty protein folding inthe cell. Professor Bukau's most recent studies ...ferent chaperon systems co-operate insuch cellular folding processes as parts of a functional network. Professor Dr. Joachim Cuntz (50), Mathematics, Universit...Untangling The Protein Folding Problem
...in their effort to solve the long-standing"protein folding problem" -- deciphering the elusive chemical code ...efforts toward unraveling the mysteries of protein folding arereported in a special edition of Accounts of Chemical Research, a monthly peer-reviewed journal p...Cells Keep Bad Guys In A Cage Until They Are Fit To Socialize
... chaperonin GroEL is essential for cellularprotein folding (Nature Structural Biology, Vol. 5, Number 11, Nov... GroEL for another round of folding. Although this folding cycle has been well established during recent years, themechanism by which GroEL contributes to the ...Ribozymes Come Ready For Action
...e hammerhead has an active site that is morelike a folding chair in that it must change shape before it can do its job. The latest x-ray pictures will help scientists in their search for nature'srules for building RNA scaffolds. Doudna says that given RNA's diversity, it's asure bet that ribozymes use a va...Cystic Fibrosis Conference Will Showcase Latest From Clinical Care To Basic Science
... strategies to correct the Delta-F508 CFTR protein folding defect Is there a role for newborn screening and early diagnosis in CF care? Long-term efficacy and safety of inhaled tobramycin (TOBI) in patients with CF Oct. 17, 9:00 a.m. - 10:00 a.m., CFTR Structure & Function: PathophysiologicInsights & Novel...