Tag: "fragment" at biology news

Powerful Anti-AIDS Agent Found In Tears And In Urine Of Pregnant Women

...anti-viral componentsassociated with the beta core fragment of the beta subunit of hCG are identicalto those of human lysozyme and ribonucleases. Why these compounds cling tightlyto the pregnancy hormone is a fascinating question, said Dr. Lee-Huang. "Hereagain, it seems that Mother Nature knows best how to p...

Vastly Different Virus Families May Be Related

...rtment, determined the precisemolecular shape of a fragment of the "fusion protein" of a paramyxovirus usingthe extremely brilliant X-rays produced by the Advanced Photon Sourcesynchrotron at Argonne National Laboratory in Illinois. The fusion protein is embedded in the membrane that envelops the virus. Itser...

Genetic Research Boosts Understanding Of Iron's Path Through Body, Diseases Of Iron Metabolism

...spects that part ofthis mysterious signal may be a fragment of the transferrin receptor that isclipped off the cell surface. Without the transferrin receptor, the intestine inthe mutant mice may never "know" about the lack of iron in the body's cells. But the transferrin receptor alone does not incre...

Target for cystic fibrosis drugs found

...t ofhands on the bed sheet and folds the defective fragment into the samehelical shape as its normal counterparts. And while heavy water is unlikelyto help patients because of its toxicity, researchers now have a simple"test-tube test" to screen possible new CF drugs. "We've finally confirmed what we proposed...

Gene that causes familial British dementia may yield clues to Alzheimer's disease

...solated amyloid fibrils revealing a unique protein fragment named ABri andleading to the identification and analysis of the BRI gene. Examples ofmutations that lead to a shorter protein are common in the literature, but it isunusual to see a mutation that extends the length of a protein. According to Creight...

NYU scientists discover gene for a dementing brain disease

...rs at a "stop codon," produces an abnormal protein fragment that forms plaques in the brain of affected family...APP sticks out from cell membranes and the amyloid fragment is formed by specific enzymatic degradation of this precursor protein. Due to the similarities betwe...

Scientists find first molecule that guides nerve cells through the brain

...that produced and secreted RoboN, theextracellular fragment of Robo. Then they used the RoboN to prevent Slit frominteracting with the normal Robo receptor. They placed pieces of septum on top of the kidney cells and cultured them withpieces of subventricular zone. When they used normal kidney cells, the sept...

Congress briefs: International congress on ecosystem health

...nd natural environment. In the long run, highways fragment habitatsand migration routes, disperse pest species and reduce biodiversity. In theshort term, highway construction and maintenance increase sedimentation, spreadof weeds, soil compaction and destruction of vegetation. Harper-Lore willexplain what ...

Simulating protein folding from physical laws

...ited-residueforce field: Application to the 10-55 fragment of staphylococcal protein Aand to apo calbindin D9K, Proc. Natl. Acad. Sci., USA, 96,2025-2030 (1999). -- A. Liwo, J. Lee, D. R. Ripoll, J. Pillardy and H. A. Scheraga, Proteinstructure prediction by global optimization of a potential energyfunct...

Common antibiotic could treat some Duchenne muscular dystrophy patients - Other genetic diseases might yield to similar strategy

...am, before the job is done. The result is auseless fragment of the dystrophin protein that is promptly removed by the cell. Working with mdx mice - a strain of mice deficient in dystrophin becauseof such a mutation - the Penn team showed that closely controlled doses of theantibiotic gentamicin allowe...

Fragment of AIDS virus may be used to deliver therapeutic proteins to cells

...rt that their way around this obstacle is to use a fragment of aprotein from the human immunodeficiency virus ...ng of the Red Sea," said Dowdy. "It's asif the HIV fragment interacts somehow with the lipid bilayer of the membrane,opens it up, inserts the protein, and then ...

Scientists discover new candidate drugs for treating HIV infection

...y these compounds, the scientists first designed a fragment of HIVcoat protein such that its vulnerable pocket...d a creative wayaround this problem and designed a fragment of the HIV coat protein thatcorrectly presents this pocket. The Kim lab then used a technology call...

Peering at a machine that pries DNA apart

...ication fork. Richardson's lab prepared a helicase fragment of the helicase primase that wasamenable to X-ray crystallography. Curiously, this fragment crystallized as anopen ring, like a lock washer, whereas the biologically active form of thehelicase...

MGH researchers first to identify genetic malfunction in type 1 diabetes

...aces. Instead of containing a peptide - a protein fragment - to display to T cells, many of the molecules were empty. This observation helped to establish Class I's role in developing immune tolerance to self proteins and was confirmed by later studies. But Faustman's work has been controversial because d...

Recombinant protein may play key role in treating immunocompromised patients

... development, scientists have identified a protein fragment that is exceptionally potent in eliciting an immun...When scientists injected a vaccine containing this fragment into mice lacking a healthy immune system, the animals were able to mount a cellular immune response...

UF researcher develops high blood pressure drug using gene therapy technique

...o so, scientists reordered the chemical units in a fragment of DNA known to be responsible for receptor production. The new material is then known as antisense because it is a reversal of the DNA message, which scientists sometimes refer to as "sense." They then packaged the antisense into a solution that cou...

Alexion and Yale discover harmful complement activation in patients with acute coronary syndrome

...ment Inhibitors, the humanized monoclonal antibody fragment 5G1.1-SC and the humanized monoclonal antibody 5G1...infarction indications with our humanized antibody fragment 5G1.1-SC." According to the European Society of Cardiology, there are approximately one mill...

Nanofabricated 'gel' separates DNA

...hey saw that in the deep sections a chain-like DNA fragment contracts into a roughly spherical shape; but in t...he barrier between a deep and shallow section, the fragment is delayed until it can stretch out thin enough to fit through the smaller space. Paradoxically, th...

New robotic microarray technology finds novel genes involved in cardiac hypertrophy and recovery

...cloned genes on glass microscope slides. Each gene fragment is capable of binding to the messenger RNA (mRNA) that codes for a particular gene's protein product. Messenger RNA extracted from heart tissue was placed on each slide. The mRNA from hypertrophied hearts was labeled with red-fluorescing dye, that fr...

Fragmented Forest, Fragmented Food

...d items brought to each nestling did not vary with fragment size, the size of the individual food items differ...n to understanding whether food supply varies with fragment size, we need to know why it may vary, " says Zanette. "A clear connection between microclimate and...

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