UNC opens first clinical trial of vaccine treatment for advanced breast cancer
... for dendritic cell growth." An engineered protein fragment of HER2/Neu is coupled with dendritic cells and re... into the patient. This molecular structure of the fragment has been changed to boost the response of T lymphocytes to kill breast cancer cells. In the clinica...Even the Immune System works with Pincers
...20 July 2000, S. 267-273). The horseshoe shaped Fc fragment of the antibody opens a little bit and picks ...rcome a series of obstacles. Since although the Fc fragment structure of an IgG antibody was solved by Huber 25 years ago, the crystallization of the whole...Faster coagulation rates found in natural systems could impact industrial processing
..., for example, often look "lacy" and every unit or fragment of it looks like the whole. Previous methods for describing and predicting the dimensions of biological aggregates have been based on the analysis of single "ideal" particles such as a sphere. However, Logan points out that most real aggregates ...East meets West: A new memory enhancing drug based on chinese herbal medicine
...ayo Clinic, Carlier found that a highly simplified fragment of the Huperzine A molecule could be easily synthe...ommercially available chemicals. In isolation this fragment is ineffective as a memory enhancer. However, based on a detailed analysis of acetylcholinesterase, ...Chemists report new approach to synthetic fragments of medically important Heparin
...ver, an entire molecule simply isn't needed. Short fragment of Heparin itself turn on or off biological activi...ons. "By then, we should be able to synthesize any fragment of the 19 building blocks as well." If the past 10 years has been the decade of genomics -- the loc...New mouse marks latest stride in muscular dystrophy research
...eam added into mouse chromosomes a particular gene fragment like the genetic abnormality that causes human disease. In healthy people, the gene that can cause the disease has five to 30 copies of a "triplet repeat," a sequence of the same three chemical bases repeated over and over. In people with myotonic dy...MIT tool impacts multi-billion dollar drug
...he new tool to determine the sequence of a heparin fragment known to have anticoagulation activity and produce... stands. The new sequence reveals that the heparin fragment produced by this particular technique contains only a partial active site, or area key to anticoagul...... California, San Francisco have isolated a protein fragment that nurtures brain cells, an effect that could pr...ss of brain function caused by the disease. The fragment acts through the same mechanisms as its larger parent protein. However, a drug based on the fragmen...Researchers identify genetic risk for Alzheimers disease
...ce has shown that it also interacts with a protein fragment called amyliod-beta42 (A42) to make fibrils. Such fibrils are found in the plaques that dot the brains of Alzheimers patients. The newly-identified region on chromosome 10 also might affect A42. In an accompanying paper in the Dec. 22 issue of Sci...Researchers discover weight-loss compound that doesnt affect food intake
...nstitute and Genset discovered that one particular fragment of Acrp30, called gAcrp30, is naturally produced by the body and works in a completely different manner compared to most available weight-loss agents. Most weight-loss drugs work by either preventing the body from absorbing fatty acids in the intes......tead, out of all the possibilities we find the one fragment that attaches directly to C3 and disables it. Compstatin owes its effectiveness and potential use as a therapeutic to its small size. Compstatins ring structure makes it resistant to proteases, enzymes that destroy proteins, so it is less likely t...Computer model predicts outcome of DNA shuffling
...ctive framework for DNA shuffling, looked into how fragment length, annealing temperature, sequence identity a...in the lab. These scenarios may include different fragment lengths, annealing temperatures or even the selection of different parent genes. " Comparisons...Benefits from Alzheimer's plaque-producing reaction? Science study proposes role in gene expression
...n for gamma cleavage, which liberates beta amyloid fragment that causes Alzheimer's disease," said Sdhof. The researchers took their lead from another protein, called "Notch," which is found in the same part of the cell as APP and is cleaved by a related enzyme. One of the Notch fragments then helps reg...Structure shows repair protein cradling broken DNA
...o mimic DNA breakage, ensuring that their test DNA fragment had only one accessible end -- in order to avoid Ku attaching at more than one site on the DNA. They accomplished this by blocking the other end of the DNA with a bulky DNA motif. After solving the structure of Ku bound to DNA, Goldberg and his colle......y, scientists only solve a piece of an antibodythe fragment at the endbecause whole antibodies do not form good crystals, an important first step in solving a structure. But by working with an antibody preparation that was unusually pure, the team managed to make crystals and solve the structure....University of Cincinnati and Air Force use algal enzyme to create new silicon-based materials
... the diatom Cylindrotheca fusiformis and used this fragment to create intricate silica patterns at the nanoscale level. "Nature makes these complex structures already," said Clarson, noting the increased interest in using biological systems to build new materials. Diatoms are tiny algae which typically prod...Researchers discover secrets of Anthrax's killer toxin
...xin-binding domain. When they mixed that receptor fragment with rodent cells and anthrax toxin in a test tube, the cells were completely protected from destruction. "The soluble receptor worked as a decoy or sponge to absorb the toxin before it could attach to the ATR on the cells," explains Dr. Young. "Now...Cyclin B1 identified as a new tumor antigen and candidate for the development of a cancer vaccine
...generated, they determined that their target was a fragment derived from cyclin B1, a protein that regulates cell growth and proliferation. They also found that cyclin B1 was over-expressed in breast and lung cancer cells, as well as squamous cell carcinomas of the head and neck, but not in normal cells, indi...African bone tool discovery has important implications for evolution of human behavior
...wood notes. Also found earlier at the site was a fragment of deliberately engraved bone (from a report published in Journal of Archaeological Science 28, Henshilwood et al. and a paper by dErrico et al in Antiquity). "Based on extensive evidence from European sites, what has been cited repeatedly is that ...NSF awards two plant genome grants to University of Minnesota
...s into fragments. Hybrid plant lines with a single fragment of a corn chromosome have been produced. Scientist...lines, each essentially an oat plant with a unique fragment of a corn chromosome. Another goal is to map more than 100,000 DNA sequences with the system. Philli...