New model of Alzheimer's enzyme may help refine future treatments
...leavage. As expected, Kopan's team found that this fragment does not compete with C99. Surprisingly, though, it did bind to the enzyme. According to Kopan, enzymes can either have one site where they interact with molecules or have separate cutting and binding sites. This study suggests that gamma-secretase b...Scientists report on promising new approaches to induce cancer cell suicide
...cell killer. In separate study, scientists used a fragment of genetic material to disable a protein used by m...ts have inhibited cancer in mice using a synthetic fragment of genetic material to block production of a protein that many tumor types use to survive. Researc...JCI table of contents, January 2, 2004
...e-3 cleaves actomyosin resulting in a unique actin fragment and other proteins that are degraded by the ubiqui...es with muscle atrophy from diabetes or uremia and fragment accumulation and the rate of muscle breakdown could be suppressed by a caspase-3 inhibitor. The repo...Smallpox in 50-year-old tissues detected by integrated diagnostics approach
.... Real-time PCR or TaqMan assays require just a fragment of genetic material that is amplified many times over to allow detection and identification of a biological agent. The technique is very sensitive and can tolerate small quantities of poor quality DNA, making it ideal for this study. The assay allo...Penguin bones from 'land of fire' rewrite bird's evolution
...ions of a pelvis, a nearly complete right femur, a fragment of the left femur and other bones. Details of the bones, and a careful comparison of them to both fossil and modern penguin bones, allowed them to unravel the evolutionary relationships of the new fossil. Clarke says that a larger, more comprehensive...Topical vaccine protects against inhaled ricin
...the study, the researchers incorporated a harmless fragment of the ricin molecule (RTA 1-33/44-198) into a transcutaneous immunization (TCI) formulation. TCI is a needle-free alternative for vaccination in which the antigen is mixed with adjuvant and applied directly to the skin or on a patch that is applied...Researchers use novel technology to extract RNA from archive formalin-fixed paraffin-embedded tissue
... tissue sample will bind to the corresponding gene fragment on the chip, researchers can analyze the expression of thousands of the sample's genes at once....Researchers go fishing, pull out antigens
...hat tells the immune system to attack that protein fragment and the organism it comes from. In most cases it i...d. Thus, they could identify the specific protein fragment any given T cell is designed to bind. They are currently working with other researchers to identify...Tips from the Journals of the American Society for Microbiology
...ch ARDRA group was established using 16S rRNA gene fragment sequencing. Results showed gram-negative organisms as the prevailing bacteria while y-Proteobacteria was identified most frequently. Also, bacterial contamination of the taphole increased to higher levels as the season progressed. "These result...Altered protein involved in a novel link to Alzheimer's disease
...significantly increased. P25 is actually a fragment of another protein, and can be formed when a stroke or some other unknown event causes the parent protein, p35, to break. But the newly created p25 behaves very differently from the protein from which it was carved out, says Dr. Tsai. Unlike its shor...Innovative efforts target epigenetics, molecular imaging
...nzyme called DNA polymerase, which copies each DNA fragment repeatedly, forming tiny, localized sets of identical fragments. These sets of fragments are embedded in the gel in a manner reminiscent of bacterial colonies, which has prompted scientists to refer to them as "polonies." Next, the polonies are expos...Firefly compound lights up 'protein dance' in living animals
...in targeted by rapamycin, attaching the luciferase fragment to the specific portion of the protein where rapam...shes its bond. They attached the other luciferase fragment to a protein known through previous research to interact with rapamycin's target protein only in the...Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
...ew vaccine candidate, called RTA 1-33/44-198, is a fragment of the ricin A-chain that has been modified to eliminate the toxic enzymatic property of RTA, increase protein stability, and maintain its ability to elicit a protective immune response. In the August online issue of Protein Engineering, Design an...Computer imaging of Archeopteryx skull suggests this dinosaur-bird link could fly
...ird-brain features of Archeopteryx from a fossil fragment brought to him by Angela Milner. The paleontologis... the UTCT facility, took 1,300 images of the skull fragment that once held the creature's brain, eyes and ears using the university's sophisticated CT scanner. ...Hopkins scientists use blood proteins to detect ovarian cancer
...e proteins as a truncated form of transthyretin, a fragment of ITIH4 and apolipoprotein A1, teased out with a rigorous evaluation of protein patterns present in blood samples from ovarian cancer patients at several U.S. and international hospitals. Other research groups are evaluating ovarian cancer blood te......ruga and Paul Schulze-Lefert discovered a mlo gene fragment which occurs in several repeats in the genome of the mutant. About ten adjacent repeats could be detected during analysis. They are located "upstream" of the wild-type gene on the DNA and are directly linked to mildew resistance. "The repeats are rea......uch a large biological system--in this case, a DNA fragment made up of 350 atoms. "With a system so big, one can't do this kind of work without a supercomputer. Fortunately, we had access to one of the world's 10 most powerful computers," housed at the W.R. Wiley Environmental Molecular Sciences Laboratory on...