Tag: "free" at biology news

JCI table of contents, 1 July 2004

...en promoted in obesity by higher concentrations of free fatty acids in the blood. Understanding how this p...e family thought to be involved in this increasing free fatty acids is the PPAR gene family. Sander Kersten and colleagues, from Wageningen University, now ...

Bacterial protein recycling factor possible key to new class of antibiotics

...e ribosome. The released ribosome is now empty and free to start a new session of translating mRNA into protein. Where RRF binds is near the key ribosomal spot holding mRNA. "Since the main function of RRF is to release mRNA, this makes sense in terms of function," explains Kaji. Humans have an RRF analo...

In the obese, metabolic adaptations post-weight loss lead to regaining of shed pounds

...n analysis and normalized to fat mass (FM) and fat free mass (FFM) acquired by dual energy x-ray absorptiometry. Results This study provides insight as to how the metabolic state of an obesity-prone rat changes from the pre-obese state to the obese state. The first conclusion reached from the data is ...

Innovative efforts target epigenetics, molecular imaging

...s." Next, the polonies are exposed sequentially to free DNA bases tagged with fluorescent markers in the presence of a different enzyme, and the incorporation of those bases into the polonies is monitored with a scanning machine. This produces a read-out of the DNA sequence from each polony. A computer pr...

Tulane opens doors to discovery

...o Discovery," two Nobel Spotlight lectures will be free and open to the public, featuring Andrew Schally and Louis Ignarro, who conducted their Nobel-winning research while on the Tulane University faculty. Schally, who received the Nobel Prize in Medicine or Physiology in 1977, will discuss his research ...

Gestational diabetes not found to alter the metabolic processes in obese pregnant women

...und) and circulating leptin. Total non-esterified free fatty acid (FFA) concentrations were measured in duplicate by an in vitro enzymatic calorimetric method. Results All subjects had normal results of routine renal, thyroid, and liver chemistries. Because of the study design there were no significan...

Antioxidants during pregnancy may help prevent birth defects tied to alcohol

...components by neutralizing the damaging effects of free radicals, natural byproducts of cell metabolism. F...hown that ethanol-induced cell death is related to free radical generation. "We have used superoxide dismutase and vitamin E and found that in the presence ...

Harmless virus helps slow HIV by boosting immune proteins

...ntibodies, GBV-C had no protective effect. HIV was free to enter host cells and proliferate. "The next thing we have to do is determine a way to mimic the effect of this virus [GBV-C] and learn how to make it persist, so it can continue to induce these chemokines and these changes in the cell that help H...

Altered protein involved in a novel link to Alzheimer's disease

...s removed from the animals' diets, the p25 gene is free to act - and the damage is quick and heavy: atrophy, neuronal death, tangles, tau, and now beta amyloid. Dr. Tsai says the questions now focus on the mechanism that causes p35 to get turned into p25. Understanding that - and having this mouse model m...

Breast cancer patients failed by treatment with taxol and taxotere respond to abraxane

...months. Additionally, 40 percent of patients were free of disease progression for as long as four months, and almost 30 percent for as long as six months. Ninety-one percent of patients were able to receive the full dose throughout the study without dose reduction. Joanne Blum, M.D., PhD., a US Oncology...

Fox Chase Cancer Center's Alfred Knudson Jr. named 2004 Kyoto Prize winner

...lishment of relationships of coexistence among all free and autonomous people. Knudson has been a senior member of the scientific research staff at Fox Chase Cancer Center since 1976. A geneticist and physician, Knudson is internationally recognized for his "two-hit" theory of cancer causation, which e...

Fat cells could provide the key to a longer life

...g less slows down the progressive damage caused by free radicals that are released when oxygen is used to breakdown fats and carbohydrates. But another theory is that calorie restriction does something critical to the insulin-signalling pathway that helps regulate how glucose is used by the body. Dr Mari...

Damaged genes in aging human brain provide clues to cognitive decline

...unusually vulnerable to damage from agents such as free radicals and toxins in the environment," said Yankner. "The brain's ability to cope with these toxic insults and repair these genes declines with age, leading to their reduced expression. It will now be important to learn how to prevent this damage,...

Kangaroo hops in line for genome sequencing

...ent of the effort. The data will be deposited into free public databases that are easily accessible to researchers worldwide. In addition to its scientific challenges, the kangaroo genome project holds a special personal appeal for Richard Gibbs, Ph.D., director of the Baylor sequencing center. Dr. Gibbs...

Need sex? It's probably something about stress

...stressed out and turn sexual. Blame it on the free radicals, says a team of researchers. Colonie...eit (42.5 degrees Celsius) had twice the amount of free radicals, oxidants that can damage biological structures, as unheated colonies. High levels of oxida...

OUP launch a new Open Access Journal on Complementary and Alternative Medicine

...ournal has also been developed to be available for free online. The 'open access' TM (OA) publishing mod...is no doubt that eCAM will benefit enormously from free access online for readers," commented Martin Richardson, Managing Director of OUP Journals Division....

APP reports Abraxane(TM) is active in breast cancer patients who failed taxol or taxotere

...0% of patients on treatment with ABRAXANE TM were free of disease progression for as long as four months; and almost 30% for as long as six months; Of those patients who progressed while on Taxotere alone in the metastatic setting (n=33), a 24% response rate was noted after receiving weekly ABRAXANE TM ...

With fat, women have a more visceral response

...ory is that excess visceral fat leads to increased free fatty acids (FFA) being released into the portal vein, thus exposing the liver to higher FFA concentrations. Increased liver exposure to FFAs could effect production of triglycerides, such as VLDL, and have an impact on hepatic insulin resistance. I...

JCI table of contents, 1 June 2004

...ory is that excess visceral fat leads to increased free fatty acids (FFA) being released into the portal vein, thus exposing the liver to higher FFA concentrations. Increased liver exposure to FFAs could effect production of triglycerides, such as VLDL, and have an impact on hepatic insulin resistance. I...

Could mice hold the secret to longer life?

...the generation of toxic by-products called "oxygen free radicals"....

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