Tag: "functional" at biology news

JCI table of contents: 1 September, 2004

...ly, when skin tumors were injected with this Stat3 functional inhibitor, tumor growth itself was impaired. This study provides the first evidence that Stat3 is required for the initiation of one form of skin cancer, and that it both mediates and maintains cellular growth through expansion of these initiated ce...

Streptococcus infects humans by thwarting blood clotting

...lasminogen. To show that the human plasminogen was functional in the mice, Sun crossed the transgenic mice with another strain in which their own plasminogen genes had been deleted. This cross essentially restored plasminogen function in the resulting mice. In test-tube experiments, Sun also demonstrated that s...

Testing the fitness of biological clocks

...ae grew dramatically faster than those that lacked functional internal timers. The normal algae also outperformed the algae with the damped clocks, but by a smaller margin. The result was presaged by a series of experiments that Johnson conducted in 1998 with Susan S. Golden from Texas A&M University and Takao ...

Scientists reinvent DNA as template to produce organic molecules

...e applied. Molecules can be "selected" for desired functional properties, and the survivors of these selections can then be copied using the polymerase chain reaction (PCR). The application of DNA-templated synthesis has enabled a collection of DNA strands to be transformed into a corresponding collection of s...

Imported fitness

...tudies for understanding the mechanisms underlying functional biodiversity....

Evidence for the impact of climate change on deep-sea biodiversity

...induce significant changes in species richness and functional diversity. They conclude that deep-sea fauna is h...apidly and significantly alter both structural and functional deep-sea biodiversity. This study provides new elements towards a better understanding of the potent...

Sweet success in targeting sugar molecules to cells in living animals

...d unnatural sugar molecules with chemically unique functional groups onto the surfaces of cells in living animals without altering the animals' physiology. The achievement is a significant advance in the promising new field of metabolic engineering because it provides a new tool with which researchers can label...

Embryonic stem cell therapy shows steady benefits in rebuilding infarcted heart

...ers transformed these master cell types into fully functional cardiac cells and transplanted them into damaged regions of the myocardium, where the cells integrated into the infarct and showed rapid and robust improvements, which were stable over an extended period post-therapy. The study, entitled "Stable ben...

When is a mouse like a test tube?

...o explore biosynthetic pathways and to examine the functional consequences of modifying the complement of cell-s...in a biological system," Bertozzi said. "We design functional groups to be specific, so they don't react with the environment in the body. Ours is an elegant syst...

The first engineering of cell surfaces in living animals

...ets these requirements. It is a reaction between a functional group called an azide (a class of compounds with three nitrogen atoms) and a phosphine (a molecule containing a phosphorus atom). Neither azides nor phosphines have harmful effects -- indeed they are useful in some drugs: the A in AZT, azidothymidine...

JCI table of contents, 16 August, 2004

...target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease AUTHOR CONTACT: Stanley L. Hazen Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, USA Phone: (216) 445-9763; Fax: (216) 444-9404; E-mail: hazens@ccf.org View the PDF of this...

Using statistics to decipher secrets of natural mutation

...ng DNA," said Green. "Mutations in DNA that is not functional should better represent the complete spectrum of n...urally occurring mutations are the 'noise' and the functional parts of the genome are the 'signal.' The better we understand the noise, the better job we can do o...

Rare mutations can significantly increase risk factor for heart disease

... in their blood, whereas individuals with only one functional copy of the gene have about half the normal plasma level of HDL. The researchers sequenced the three genes and looked for changes in the DNA that would alter the resulting protein. Such variations were found in 16 percent of the individuals with l...

Marijuana ingredient inhibits VEGF pathway required for brain tumor blood vessels

...e, a lipid mediator of apoptosis, resulting in the functional inhibition of cells needed for VEGF production. The ability of cannabinoids to alter VEGF production was significantly stifled following the introduction of a ceramide inhibitor. "As far as we know, this is the first report showing that ceramide depr...

Scientists identify compounds that mimic calorie restriction

...pared responses in normal mice to mice that lack a functional PPARalpha to determine if PPARalpha was directly involved in any of the responses that are induced by calorie restriction. They found that the PPARalpha-mutant mice lack many of the characteristics of calorie restriction, including changes in genes t...

NHGRI adds 18 organisms to sequencing pipeline

...proach we currently have to identify the essential functional and structural components of our own genome is to compare it with the genomes of other organisms. With each new genome that we sequence, we move closer to the goal of finding all of the crucial elements of the human genome involved in development, he...

Outcome for acute lymphoblastic leukemia linked to gene expression patterns

..., genes linked to resistance belonged to different functional categories (i.e., they did different tasks in the cell) and these differed for each medication. "Learning the function of these genes gives us new insights into the causes of resistance to individual drugs used to treat children wi...

Gulf of Maine marine ecosystem may have entered new phase

...cause the 'driver' species increasingly fall below functional population densities," Steneck explains. "When a threshold is reached, the system changes fundamentally. Everything that came before it is thrown out the window. What this does in the long run is make the system unpredictable." For ...

JCI table of contents, 2 August, 2004

...t had been genetically altered so that they lacked functional interferon- gamma, the invasion of cells into the bile ducts was blocked. However, giving the mice interferon-gamma following infection resulted in bile duct blockage. These data identify interferon-gamma as a key player underlying this deadly condi...

New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine

... of SARS-CoV" are Denong Wang, who was head of the functional genomics division of Columbia University Genome Center, College of Physicians & Surgeons, New York, New York; and Jiahai Lu, Associate Professor at the School of Public Health at Sun Yat-sen University, Guangzhou, China. Lu also is in charge of the ...

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