Tag: "functional" at biology news
UNC scientists uncover crucial mechanism for blood vessel development
... molecular pathway. Most of the time you don't get functional
vessels, but a set of dilated vessels that haven't made the right connections," said Bautch. "We, along with others, are now beginning to unravel the complexity of this pathway. We think the flt-1 receptor actually regulates the amount of VEGFA requi...
Organization for Human Brain Mapping 2004 Annual Meeting
...new findings continue to characterize the field of functional
brain imaging - the method by which brain activity can be observed in awake, behaving organisms, including human beings. The latest developments in this field will be presented at the annual meeting of the Organization for Human Brain Mapping (OHBM)...
Alzheimer's may leave some forms of memory intact
...sification task as their brains were scanned using functional
magnetic resonance imaging. "What was surprising and novel in this study is that the brain region with the greatest activity during the task was the high-level region of the frontal cortex," said Buckner. "We didn't expect this because high-level cog...
LARGE protein can overcome defects in some types of muscular dystrophy
...ansferase known as LARGE is mutated. Mice without functional
LARGE have a type of muscular dystrophy similar to...ithout this recognition, alpha-dystroglycan is not functional
in muscle. They propose that the interaction between LARGE and alpha-dystroglycan is a key determina...
Carnegie Mellon U biologists identify critical player in yeast ribosome assembly
...critical step in the pathway to assembling a fully functional
ribosome," explained John Woolford, professor of b...r wild-type, gene instructed production of a fully functional
S14 protein, while a mutant gene coded for the production of an S14 with an altered tail. After grow...
Loss of circadian genes results in epilepsy
...otein levels barely change. To explore the functional
significance of the PAR bZip protein family, Dr. Schibler and colleagues disrupted one, two, or all three of the PAR bZip genes in mice. The single, double, and triple knock-out mice (as they are known) appear normal, but it quickly became apparent t...
Late invasion of infected cells into the brain causes HIV dementia say Temple researchers
...the brain, adapt to their location and take on the functional
characteristics of the resident migroglia. "They're then activated and there are many more of them," he adds. Rappaport and his colleagues also looked at proliferation markers such as Ki67, but ruled out proliferation as being responsible for ...
Tamoxifen stimulates breast cancer growth following alteration of estrogen receptor
...reast cancers are stimulated by estrogen acting at functional
estrogen receptors (ER+), they are most often treated with anti-estrogen compounds that inactivate the estrogen receptor. The most common of these is the drug tamoxifen. However, only about half of ER+ breast cancers successfully respond to treatment...
Research gives hope to preemies and Crohn's patients
...ly causes intestine to grow back but makes it more functional
as well. The research will be published as the 20...d, the remaining segment will grow and become more functional
in an attempt to compensate for the part that's gone. "But you have to be able to feed patients oral...
Tufts researchers identify a novel target for cancer therapy
... Cancer Cell Invasiveness," the researchers used a functional
screen on the cell surface proteome of a highly in...The researchers demonstrated a direct physical and functional
interaction between hsp90 and matrix metalloproteinase 2 (MMP2), a primary player in the tumor invas...
Gene at root of urban air pollution's lung effects
...s. The researchers exposed mice with and without a functional
copy of the gene TLR4 to four environmental challe...g copy of the innate immunity gene. Mice lacking a functional
copy of TLR4 continued to suffer lung injury in response to particulate matter and acute ozone expos...
Genomic biology institute's first grant to focus on soybeans, climate change
...nd Functional Genomics at Illinois and the soybean functional
genomics laboratory directed by crop scientist Lila Vodkin. It also will build upon already existing research at SoyFACE, a futuristic crop experiment on the South Farms where corn and soybeans are growing in open field conditions under concentratio...
Genetic barrier to self-pollination identified
...g from duplication of the pollen S-allele) remains functional
in self-incompatibility. The team carried out three sets of experiments. In one set, the S2-allele of PiSLF was introduced into plants of S1S1 genotype plants containing two identical S-locus genes of a type labeled S1 - via standard plant transform...
Imaging study shows brain maturing
...n maturing at ages in which relevant cognitive and functional
developmental milestones occur. The sequence of maturation also roughly parallels the evolution of the mammalian brain, suggest Drs. Nitin Gogtay, Judith Rapoport, NIMH, and Paul Thompson, Arthur Toga, UCLA, and colleagues, whose study is published o...
ADAM: Good enzyme for Alzheimer disease
...formation, prevented plaque formation, and, from a functional
standpoint provided improvement in both long-term potentiation and cognitive impairment. On the other hand, mice lacking ADAM10 had increased number and size of amyloid plaques. The data here provide evidence that a-secretase might be a useful ther...
JCI table of contents, 17 May 2004
...formation, prevented plaque formation, and, from a functional
standpoint provided improvement in both long-term ...20208.pdf ACCOMPANYING COMMENTARY: Dissecting the functional
role of different isoforms of the L-type Ca2+ channel AUTHOR CONTACT: Emmanuel Bourinet, Laboratoire...
Plant-like enzyme acts as key life cycle switch in malaria parasite
...s Dr Billker. "We combine them with new methods of functional
analysis such as microarrays, which tell us what genes are active at specific stages of the parasite's life cycle, and they are giving us great insights into the molecular components involved in signalling and regulation of the parasite." "We will us...
Dartmouth Medical School awarded $9 million grant for genomics research
...tutes of Health grant to direct a collaboration in functional
genomics that will be one of the most comprehensive to date within the group of organisms studied. The award to DMS's department of genetics from National Institute of General Medical Sciences will be used primarily to analyze the roles and function...
22-amino acid bacterium created by Scripps scientists
...article, "A twenty-two amino acid bacterium with a functional
quadruplet codon" is authored by J. Christopher Anderson, Ning Wu, Stephen W. Santoro, Vishva Lakshman, David S. King, and Peter G. Schultz and will be posted online during the week of May 10-16, 2004 by the journal Proceedings of the National Academ...
Functional genomics enables easy target identification and drives drug discovery
...es. "As opposed to conventional sequence homology, functional
genomics adds structure-based predictions to locat...cific molecules and target proteins. Additionally, functional
genomics opens up the possibilities of genetically demarcating patients and predicting individual re...
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