Treatment stimulates growth and regeneration of injured adult skeletal muscle
...uscular dystrophies," explains Dr. Sartorelli. The functional link between HDAC inhibitors, follistatin, and adult muscle regeneration is especially provocative as an HDAC inhibitor is already being used clinically in humans as an anti-cancer therapeutic....Surprising 'ultra-conserved' regions discovered in human genome
...urpose. Bejerano and his colleagues sought to find functional elements within that 3.5 percent. "We began by looking for meaningful families within these conserved, noncoding elements," he said. Some of them fell into clusters of at least two elements with a common genomic ancestor. These were most likely d...Findings redefine mechanism of action of RNA helicase enzymes
...turn the blueprints into a real three-dimensional, functional and safe structure. RNA has numerous functions in a cell, including translating the genetic blueprints found in DNA and catalyzing reactions in the cell to build proteins. In order to carry out its functions, strands of RNA molecules will bind wit...Scripps scientists look deep inside sharks and their high-performance swimming system
...two, including the dynamics of steady swimming and functional design of their complex locomotor systems. The researchers set out to investigate the evolutionary crossroads between lamnid sharks and tunas in regards to the mechanics and architecture of their muscle-tendon systems. Recent research has uncovered ...The science of overcrowded life boats and other moral dilemmas
...al reasoning springs from emotion or reason. Using functional magnetic resonance imaging (fMRI) technology, researchers have found that parts of the brain associated with emotion play roles in processing some moral dilemmas, but not all of them. Understanding why different kinds of moral dilemmas are processed...NASA-inspired technology may help preserve women's future fertility after cancer treatment
...s, including immature eggs and follicles, the main functional portion of the ovary. Under normal circumstances, follicles remain dormant until triggered at puberty to cycle through several stages of development before reaching full maturity. Eggs are nurtured within the follicle. Once all the follicles are gone...UCLA chemists develop new coating for nanoscale probes
...between nanoscale inorganic electronic devices and functional proteins, which would lead to the evolution of nov...mart catalysts,' 'protein switches' and many other functional hybrids of inorganic-organic substances. "The possibilities are endless," Weiss sai...Annotation marathon validates 21,037 human genes
...about 30,000 genes in humans, so having a detailed functional map of a majority of them will be a boon for geneticists, drug researchers and genome scientists around the world. There is a wealth of information, including evidence for several thousand new genes, data about variable expression and genetic variat...Prenatal nicotine primes adolescent brain for addiction
...ster nicotine in an attempt to replace the brain's functional loss. Furthermore, that deficient brain response might drive higher cigarette consumption. Collaborators on the studies include Yael Abreu-Villaca, Ph.D., Frederic Seidler, Ph.D., Charlotte Tate and Mandy Cousins, all of Duke....Insights on stroke from the peripheral blood suggest ways to develop markers and therapies
...flow and thus slow brain death. The development of functional MRI sequences (continuous images of brain activities) provided valuable new insights into how ischemic stroke progresses in humans during the period of ischemic lesion evolution when the infarct zone is expanding and when giving drugs to restore blo...Brain cells become more discriminating when they work together
... determine whether this "neuronal synchrony" has a functional role or if it is just a by-product of the brain's ...er method major method for mapping brain activity functional MRI measures chemical changes in the brain, not electrical ones, so cannot be used for this purpose......s, the image may not distinguish between different functional parts. Now, Prof. Hadassa Degani of the Biological Regulation Department and her lab team have found a way to see into the kidneys using magnetic resonance imaging (MRI) that scans sodium ions rather than water. Their method ta...Brain signal predicts working memory prowess
...showed large increases. Using a similar task with functional magnetic resonance imaging (fMRI), a research team at Vanderbilt University reports in the same issue of Nature that the posterior parietal cortex, an area at the top rear part of the brain, is the brain area responsible for holding representations i......ightly darker. This is similar to the way in which functional MRI works. A critical difference is that fMRI is non-invasive and so it can be used on people, while optical imaging requires that a portion of the skull be removed to reveal the brain, limiting its use to animal subjects and patients undergoing spec...Keck Futures Initiative announces grant recipients
...able; that is, they can change to adapt to altered functional pressures. In this grant, we propose to develop new methods for studying the origin of these properties in proteins, and then plan to test hypotheses through building artificial proteins. The ultimate goal is to understand the design principles in ...Imaging the brain solving problems through insight
... and electrical signature of neural activity using functional magnetic resonance imaging (fMRI) and the electroencephalogram (EEG). Neural activity was mapped with fMRI while the participants were given word problems--which can be solved quickly with or without insight, and evoke a distinct Aha! moment about h...Purdue scientists finding ways to outsmart crop-damaging bugs
... field, then we have the potential to increase the functional life of the insecticides currently in use." Crop-damaging insects mutate over time so they are able to overcome the effects of chemicals developed to kill them. A toxin that protected a crop for more than a decade or two eventually may lose its letha...Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
...arts, based on their ability to contract and other functional properties of these cells was also improved," Dr. Koch says. "This is the first work in actual human hearts to show efficacy of ARKct as a potential therapy and more importantly, proves that the enzyme ARK1 is a target for heart failure treatment." "...Functional food Safety aspects
...he past few years, the potential benefits posed by functional foods have led to an increased interest by produce... from scientific proof of the beneficial effect of functional food, a well-founded safety evaluation is also necessary. In the opinion of the DFG Senate Commissio......cases, however, the underlying cause seems to be a functional blockage, for which the molecular basis remains un...ts inhibited normal pyeloureteral peristalsis -- a functional obstruction that ultimately leads to fatal renal failure. This study provides evidence for a direct...