Scientists Discover How Genes Work Together To Control Neural Development
...fident that together Phyllopod and Sina bindto the gatekeeper protein, Tramtrack, which is the kiss of death tha... garbage-disposal enzymes," Carthewsays. "Once the gatekeeper Tramtrack protein is removed, the cellis free to become a neuron." "Up until a few years years ago...'Gatekeeper' protein is key to cellular life; links bacteria, chloroplasts and mitochondria
...found within the membranes of bacteria serves as a gatekeeper of sorts, allowing into the membrane other proteins essential for the bacteria to live. When YidC isn't present, the bacteria die. The finding surprised scientists who long believed that certain "independent" proteins were able to pass into the m......to humans. The revealed structure of the cellular gatekeeper is so detailed that the scientists have determined for the first time how the channel works, bringing them closer to understanding how therapeutic drugs affect movement of molecules through membrane channels -- research that can help develop treatmen...Health websites can be unhealthy
...ything. There is no governing body that acts as a gatekeeper of Web pages, and we found that a lot of health information out there is inaccurate and just not true." There are more than 43 million web sites, Dorman says, and at least 10,000 of those post health information. One big problem deals with getting t...Krauss book explores universe from oxygen atom's perspective
...oxygen protagonist to earth. The planet acted as a gatekeeper for space objects, either sending them outside the galaxy into the Oort Cloud beyond or as a barrage of matter to Earth or other inner planets in the solar system. Inside one of many comets that rained down upon the earth and helped to seed it with ...Columbia team finds treatment that corrects cellular defect at the root of heart failure
...m, a sac containing calcium ions, and is the major gatekeeper for calcium ion release. The more calcium released through the ryanodine receptor, the stronger the contraction of the heart. Dr. Marks and his colleagues have discovered that one of the ways in which the ryanodine receptor can be activated to releas...Chemists explore the shape of the key that signals cell division in cancer cells
...ch initiates mitosis or cell division. Pin1 is the gatekeeper to cell division. Without Pin1, the cell enters programmed cell death -- which is a good if its a cancer cell. "We are designing small molecules that are peptide mimics. In this case, we have synthesized a peptide locked into two shapes, or conforma...JCI table of contents, July 15, 2003
...//www.the-jci.org/press/17008.pdf Neph1 as the gatekeeper in the kidney Recent studies have identified a central role for the podocyte slit diaphragm as a size-selective barrier for plasma macromolecules in the kidney, and extensive progress has been made in identifying key proteins contributing to the s......e class of molecules serves as the immune system's gatekeeper in the lungs, damping the immune response in some situations and promoting it in others. The findings, published in the October 3 issue of the journal Cell, resolve an apparent paradox that prevented researchers from understanding how these versatil...Research collaboration identifies gene essential to puberty
...tions. "It looks like we have found a key genetic gatekeeper of puberty in mice and men," says William Crowley Jr., MD, chief of the MGH Reproductive Endocrine Unit and director of the Harvardwide Reproductive Endocrine Sciences Center, one of three co-senior authors of the NEJM report. "Most other genes invol...New study identifies gene signaling puberty
...ations are infertile. "The discovery of GPR54 as a gatekeeper for puberty across species is very exciting" said the study's first author, Stephanie B. Seminara, of the Reproductive Endocrine Unit, Massachusetts General Hospital, Boston and a member of the NICHD-funded, Harvard-wide Endocrine Sciences Center. "...Scientists develop a novel strategy to help prevent transplant rejection
...wn as Notch, which the researchers found acts as a gatekeeper by governing how immune cells specialise. Results show that exposing the mice to a combination of the Notch signal and material from the donor two weeks in advance of transplantation stimulates an immune response and significantly increases transplan...JCI table of contents, December 15 2003
...press/17450.pdf TRPV5: the calcium gatekeeper Ca2+ ions play a fundamental role in many cell... show that the TRPV5 channel acts as the molecular gatekeeper in facilitating Ca2+ reabsorption in the kidney. Despite enhanced vitamin D levels, mice lacking TRP...Stuart Lipton honored with Jung Prize for Medicine
...nction. Dr. Lipton discovered ways to control the gatekeeper receptor, NMDA, and moderate the activity through these pathways. The prototype treatment based on Dr. Lipton's concept is a drug for Alzheimer's Disease. Dr. Lipton was the first to discover a unique mechanism of action for the drug Memantine, a...Synthesized molecules studied as weapon to stop cell division in cancer cells
...rg, Va., Aug. 23, 2004 -- An enzyme called Pin1, a gatekeeper of cell division, is present at high levels in a wide variety of cancer cells. Virginia Tech researchers who are designing small molecules to inhibit Pin1 are seeing promising results with a small U-shaped molecule. Felicia Etzkorn, associate profess......er plants. Once released, Smac binds to a group of gatekeeper proteins known as "inhibitor of apoptosis proteins" (IAPs), which normally hold in check the cell's chief executioner enzymes. These enzymes, called caspases, wreak lethal havoc in cells targeted for apoptosis. Smac's action is why it was named the "...