Scientists suggest framework for epigenetics in common disease
... information, such as identifying which parent the gene came from. The marks also normally turn genes on o...ple, if a disease-causing mutation is present in a gene turned "off" by its epigenetic marks, then the mutation can't cause disease. More subtly, alteration...Researchers look into components of RNA silencing machinery
...e biology. The RNA silencing machinery silences gene expression, by destroying RNA, a molecule that car...ly will lead to conquering disease by the means of gene therapy, says Rodolfo Aramayo, associate professor of biology at Texas A&M University, who specializ...NIH renews funding for continued Rb2 tumor suppressing gene research at Temple
... his exploration of the role the tumor suppressing gene Rb2/p130 plays in cancer. An internationally recognized researcher in the genetics of cancer and gene therapy, Giordano discovered Rb2/p130 in the early 1990s while serving as a member of Temple's Schoo...Hunt for a new plant hormone points to carotenoids
...sity of York has come one step closer in finding a gene required for the hormone's synthesis. The biochemi...er and co-workers describe the identification of a gene that is essential for the synthesis of this novel hormone. The gene encodes a protein that they show...Insecticide resistance: A constraint on evolutionary change
... G119S, within the mosquito's version of the AchE1 gene conferred high levels of resistance to these insec...lations. Looking more closely at the Ae. aegypti gene sequence for AchE1 revealed the answer. The researchers found that in this species, the three-letter...Location of potential familial lung cancer gene discovered
...ompared the alleles (the different variations each gene can take) of all affected and non-affected family ... strong evidence that a lung cancer susceptibility gene or genes is co-inherited with a genetic marker on chromosome 6. Markers on chromosomes 12, 14, and ...Gene therapy reaches muscles throughout the body and reverses muscular dystrophy in animal model
Researchers have found a delivery method for gene therapy that reaches all the voluntary muscles of ... been a major obstacle limiting the development of gene therapy for the muscular dystrophies. Our new work identifies for the first time a method where a n...Growing new breed of vaccine-producing plants to fight human diseases worldwide
...cture" subunit vaccines consisting of the pathogen gene products. Simple feeding of the plant tissues to animals or humans results in an immune response to the subunit vaccines," Arntzen commented. Arntzen's research focuses now on producing vaccines in tomatoes to fight human afflictions suc...Bone, enamel, dentine, milk & saliva share gene family
...es do not exist in all vertebrates. "Birds have a gene to make hard egg shells, but they do not have gene...," says Kawasaki. "Birds probably lost the enamel gene so long ago that there would be no trace of it." The researchers have traced the development of the...Microarrays, key genome expression trackers, work better when probes are sequence-verified
...of cellular regulation. In addition, comprehensive gene expression profiling shows great potential for hum...of thousands on a single slide are often based on gene sequences that are five years old, or more. Background Frustrated by more than two years of tryin...Gene defects found in age-related macular degeneration
...archers have identified subtle defects in a single gene that underlie a hereditary form of age-related mac...atients each had a different change in the FBLN5 gene that was not found in the healthy control group. Six of these seven changes altered an amino acid in...Pump failure implicated in a form of dystonia
...called ATP1A3, as common in all the families. This gene is the blueprint for a protein that is a key catalytic subunit in a larger enzyme that pumps sodium and potassium across the membranes of neurons, using the energy of ATP to do so. Such transport is critical to maintaining the gradients of those subs...Research reveals role of gene in infertility
A paper describing discoveries about the role of a gene that is important in all animals, plants, and fung...rprising results of the research is that the RAD51 gene is not essential for survival in plants, as it is known to be in mammals. "It is well known that a ......rm the vertebrate head. In zebrafish mutated for a gene called integrina5, the authors report, a specific region of the jaw support (hyosymplectic) cartilage fails to develop. Integrins are cell surface proteins that promote cell adhesion and signaling. Crump et al. show that Integrina5 promotes the devel...HIV reveals evolution of a primate defense against intragenomic infiltrators
...led positive selection. As predicted, the APOBEC3G gene is under strong positive selection. But that selection characterized by an analysis of twelve primates species spanning 33 million years of evolution - appears to predate the existence of HIV-type viruses. So, what has been fueling APOBEC3G's rapid...A pathway to blocking autoimmunity
... in dendritic cells, the researchers profiled each gene regulated by PPAR-gamma to characterize the pathwa...show that PPAR-gamma regulated the expression of a gene called CD1d, which encodes a glycoprotein responsible for the presentation of self and foreign lipid...How wounds heal Clues from flies
...r defective. In contrast, larvae with defects in a gene required for the generation of crystal cells--a type of blood cell implicated in processes linked to scab formation--could not properly form scabs. In these scabless wounds, cells at the wound's margin started to close the wound but often failed, and...NRH1 and Wnt signaling come together in convergent extension
...ctor, Yoshiaki Sasai) show that the product of the gene NRH1 is essential to the regulation of CE movement...posterior neuroectoderm, Sasai et al. identified a gene encoding a protein that showed similarities to p75NTR, a neurotrophin receptor. (Neurotrophins are m...Researchers identify gene for a primary form of sudden infant death sydrome (SIDS)
...uses before their first birthday. By discovering a gene linked to some of these deaths, a team of research...anding of the syndrome, the researchers believed a gene called TSPYL, which is expressed both in the brainstem and in testes, might be responsible for the s...LSU vet school professor uses gene therapy to destroy cancerous tumors
...f Comparative Biomedical Sciences, is developing a gene therapy treatment for cancer that could ultimately...s research focuses on electroporation and cytokine gene therapy in cancer treatment. Electroporation involves injecting a therapeutic gene, or "tumor killer...