White House to honor UNC School of Medicine scientist for 'early career' achievement
... research interests are chromatin biochemistry and gene regulation. Chromatin, a complex of nucleic acids and proteins, binds DNA into higher-order structures, ultimately forming a chromosome. The National Science Foundation and the National Institutes of Health are among 11 federal agencies participating...Joslin Diabetes Center adds first affiliate in California at Irvine Medical Center
...heart muscle from dying. The findings suggest that gene therapy might help treat a variety of heart diseases, as well as stave off heart damage that is common among diabetes patients. "Over 1.5 million people in California have diabetes, and statistically, a third of them don't know they have the diseas...Missing genes may help explain why plague bacteria are so deadly
...emy of Sciences, the researchers said the "massive gene loss" and DNA rearrangements that occurred as Y. p...rtant finding was the extent and apparent cause of gene inactivation in Y. pestis. "As many as 13 percent of Y. pseudotuberculosis genes no longer function ...OutFoxed! New research may redefine late-stage cardiac development
...ggest this work may be crucial in determining what gene mutations might lead to congenital cardiovascular defects. Cardiac development is conserved in mammals so defects in early cardiovascular development may lead to malformations in the human heart. "Although there have been no substantiated reports of...Disruption of protein-folding causes neurodegeneration, mental retardation
... examined the spinal cords of mice that lacked the gene for beta-galactosidase, the enzyme also missing in...re dying cells in spinal cords of mice missing the gene than in normal mice. In addition, the St. Jude investigators studied the effect of adding large amou...Researchers discover why mutant gene causes colon cancer
... adenomatous polyposis coli (APC) tumor suppressor gene have been found to cause 85 percent of colon cance...g time, scientists believed they knew what the APC gene did that it regulated cell growth and division but now we know we've been missing a big piece of t...Breaking new ground in germ cell guidance
...r the guidance gene, wunen2 . The products of this gene and its relative, wunen , have been known for some... gonadal destination. The overexpression of either gene in somatic cells had also been shown to cause the death of pole cells, indicating their importance t...Hunting illusive signs of natural selection
...t apart, decimated populations expand from smaller gene pools, and populations mix with each other. Mos...s." The researchers cannot identify an individual gene in the cluster of four that was selected, but one of the genes, TRPV6 might be involved in susceptib...Adaptive changes in the genome may provide insight into the genetics of complex disease
... aggressiveness of prostate cancer. It and another gene in theregion, TRPV5, are also involved in calcium ...ts had previously found that geneticvariation in a gene promoting lactose-tolerance in milk drinking Europeanpopulations was selected for some 10,000 to 20,...New genetic hypothesis for the cause of autism
...A sequence is intact, the researchers believe that gene expression could be faulty. They suggest that some...opose that there is a major epigenetic (related to gene expression, not sequence) component in the etiology of autism involving genetic imprinting. They sug...Maine-based biophysics institute gets funding for first US-based 4Pi nanoscale microscope
... specific structures within a cellsuch as a single gene on a chromosomeat a resolution four to seven times greater than previously possible. "Astronomers have space-based telescopes like the Hubble Space Telescope to understand the history and structure of the universe," comments IMB co-director Barbara...A new protein is discovered to play a key role in cancer progression
...or suppression and in regulating the function of a gene crucial to the suppression of the genesis of cancer. In this current work, the Sloan-Kettering researchers found that cytoplasmic PML (cPML) also has a key role in cancer development. It is required for the formation of a signaling complex that i...Do genes respond to global warming?
...es--environmental change, population response, and gene diversity fluctuations--and report that climate ch...y et al. predicted and subsequently found that the gene diversity fluctuations of the two species differed based on their different ecological behaviors....Fossils reveal direct link between global warming and genetic diversity in wildlife
...rge populations of animals, "this study shows that gene flow is occurring when population sizes are low," Hadly said. "So the snapshot we have today about how populations are connected may not be how it actually persists through time." The study also has implications for wildlife managers in the greater Y...Heart gene yields insights into evolution, disease risk
...requency among human populations of a variant in a gene that influences vulnerability to heart disease, biologists have found evidence that the gene has been influenced by the pressure of natural selection. What's more, this evolutionary pressure ha...Genetic map of important tree genes outlined
...l stresses. The study also compared many of these gene sequences to those found in Arabidopsis, and found...poplars with asexual biotechnology methods such as gene transfer, provides a tremendous advance for basic research in trees. Even if regulations continue to...Recent evolution at a single gene may have brought down heart disease risk in some human groups
...lions in the human genome that helps regulate the gene stromelysin-1, or MMP-3. The identity of the DNA b...Individuals with the low-expression version of the gene are slightly more prone to atherosclerosis, the narrowing of the arteries associated with the accumu...How do you mend a broken heart?
...ade great advances in the understanding of cardiac gene expression. Prof. Rosenthal predicts that the team will make major advancements. "We've been given a unique opportunity to share the expertise, facilities, models and knowledge of this superb group of scientists." And although many of these scientist...Single isolated mouse skin cell can generate into variety of epidermal tissues
...e team wasn't quite finished. They used microarray gene expression to determine if the genes expressed by their stem cells were also expressed by other known stem cell types -- blood, embryonic and neuronal stem cells. "We have found more than 50 genes that are turned on by all the stem cells that our gr...Identifying tick genes could halt disease, bioterrorism threat
... as to the types of genes present in ticks and how gene expression changes when ticks are infected with disease-causing microorganisms. "Once we begin to collect the genome data, we will analyze what the genes do and how they control tick behavior, including how they are able to spread disease," she said....