Tag: "gene" at biology news
The birth of a beak
...ndeed a growth mediator, they used techniques from gene
therapy and protein delivery to mis-express BMP4 and its antagonist. "The results," Chuong says, "were astounding. The chicken beaks were modulated into a spectrum of beak shapes mimicking those seen in nature." An accompanying paper in Science , wh...
Skin stem cells give hairless mice hair
...ells they isolated showed a molecular signature of gene
activity that demonstrates their "stemness." Such characteristics, she said, represent the beginning of a broader effort to compare the genes activated in many stem cell types, to understand the factors that control their proliferation and differenti...
Essential smell gene may provide key to new insect repellents
...e gene, known as Or83b, cannot smell. Because the gene
is found in a wide variety of insect species, the ...als that the brain perceives as smell. A different gene
codes for each kind of receptor, and the Or83b receptor is unusual in two ways. First, nearly all th...
Zoledronic acid zings cervical cancer
... acted by both decreasing matrix metalloprotease-9 gene
expression and inhibiting the activity of any remaining matrix metalloprotease-9 protein. This study provides evidence that an already approved drug, zoledronic acid, may be useful for therapy in cervical cancer and other diseases resultant from matr...
Study reveals first genetic step necessary for prostate cancer growth
...hen mice are engineered to lose a single copy of a gene
called Rb in their prostate, they develop a precan...eenberg and colleagues focused on the Rb gene. The gene
is known to be defective in a variety of cancer types, including up to 60 percent of human prostate ...
Convulsions in worms mimic epileptic seizures
... mutation in the LIS1 gene. In its human form, the gene
has been linked to a rare birth defect called liss...ease." The team identified a mutation in the LIS1 gene
that causes the encoded protein to be only one-fourth the length of the normal protein. The mutation...
Purdue study finds antioxidant protects metal-eating plants
...ickel tolerance. He and his colleagues isolated a gene
called SAT, and inserted it into a model lab plant...iana, which does not normally tolerate nickel. The gene
SAT produces an enzyme called serine acetyltransferase, which plays a role in producing glutathione ...
JCI table of contents: 1 September, 2004
... acted by both decreasing matrix metalloprotease-9 gene
expression and inhibiting the activity of any rema...sed a transgenic mouse that carried the luciferase gene
under the control of a portion of the NF-kB promoter; thus, if conditions were such that the NF-kB g...
Researchers identify the genome's controlling elements
... to understanding how the genome is controlled are gene
regulators, also known as transcription factors. T..., close to a particular gene, and then switch that gene
on. They can also influence the amount of protein that the gene
will produce. Many diseases, such as...
Analysis of gene expression in lymphoid cells can determine lymphoma cancer
Analyzing the expression levels of the gene
CDK9 (cyclin dependent kinase) and its attached mo...ecognized researcher in the genetics of cancer and gene
therapy. "The change of levels of CDK9 and CYCLIN T1 in lymphoid cells shows a correlation with act...
Scientists discover proteins involved in spread of HIV-1 infection
... it uses to recruit the human tumor susceptibility gene
101 (TSG101). The virus then uses TSG101 to take control of the protein sorting and vesicle formation machinery and use it for its own purposes. Previously, scientists determined that the yeast version of TSG101, called Vps23p, binds to two other ...
Protein involved in childhood disorder linked to cancer
..."If so, then restoration of MCPH1 function through gene
therapy, or upregulation of pathways involving MCPH1 through other means, could forestall cancer development in individuals known to harbor such mutations. Also, drugs that antagonize MCPH1 in tumors that also have other checkpoint defects may sensit...
NIGMS funds Center for Quantitative Biology
...in living cells and tissues. They will also create gene
chips to study the activities of genes from viruses, bacteria, yeast, mice, rats and humans. A key feature of the project is the use of advanced computational methods to model complex biological systems based on large quantities of experimental dat...
Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
...genetically engineered mice with a mutation in the gene
NPAS3 , a mutation in the gene
NPAS1 or a mutation in both genes. Both genes encode proteins that switch other genes on and off i...
APS awards more than $140,000 to minority students of physiology
...ns including energy metabolism, water homeostasis, gene
expression, and muscle contraction. Structural variations in cAMP-dependent kinases give these enzymes the flexibility to regulate multiple cellular processes. This research will help in understanding one mechanism by which cells formulate response...
Humans march to a faster genetic 'drummer' than primates, UC Riverside research says
... that they give rise to new proteins or an altered gene
regulation. Sometimes the mutations result in the growth of a cancer tumor, or some other genetic defect. The team, which also included Rosaleen Gibbons, Lars J. Dugaiczyk, Thomas Girke, Brian Duistermars and Rita Zielinski, identified over 2,200 ne...
Highlights of American Chemical Society national meeting in Philadelphia, Aug. 22-26
...n Germany have identified, for the first time, the gene
that is responsible for producing the chemical that is thought to be chiefly responsible for the unique flavor of strawberries. The finding could lead to more flavorful strawberries as well as genetically engineered hybrid fruits with unique flavors ...
Streptococcus infects humans by thwarting blood clotting
...rable to bacterial streptokinase, Sun attached the gene
for human plasminogen to a regulatory DNA sequence that normally activates the gene
for a mouse blood protein, albumin. This protein is produced in large amounts in the animal. The res...
New genetic research demonstrates possible cause of inherited form of Parkinson's disease
...hat may pinpoint the mechanism by which the mutant gene
initiates a cascade of events that causes this dev...esearch that discovered the mutant alpha-synuclein gene
and it is exciting to see how this information can be used to possibly determine the cause of Parkin...
Washington University in St. Louis plays key role in sequencing moss genome
... genes to be made that will give us insights as to gene
function. Also, the basal position of Physcomitre...s resources including EST collections, analysis of gene
expression and mutant collections. Quatrano said that the collaborators are hopeful that, as seque...
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