Researchers report new gene test for isolated cleft lip and palate
...Institutes of Health. The authors say their latest gene test applies to about 12 percent of isolated cleft...heir colleagues reported that mutations in another gene account for about 2 percent of all cases of isolated clefts, meaning researchers in the field now ca...Gene associatied with lupus identified
...f Minnesota have identified, for the first time, a gene variation associated with systemic lupus erythemat...toimmune disease that affects multiple organs. The gene variation, known as PTPN22, is found in approximately 16 percent (or one in six) of healthy Caucasia...UCR earns $1.5 million grant to examine how engineered crop genes stray
...collaboration with biological scientists who study gene transfer and the evolution of invasive species." ...nces. The result will be the first global model of gene flow that accounts for both human and natural processes of gene dispersal. "This is really very ex...... in feedback loops, in which the expression of one gene turns on the expression of a second gene, which tu...h turns off the second gene, which turns the first gene back on, etc., day in and day out. However, in real life, the situation is not so simple as a loop...Gene linked to cleft lip and palate identified
...international team of researchers has identified a gene variant that is a major contributor to oral clefts..."This gives us confidence that the linkage of this gene variant to oral clefts is true across different populations in the U.S. and worldwide." The March of...New model can aid in understanding immune system diseases
...nned. The mice used in the study either had only a gene that coded for the normal protein or only a gene that coded for the viral protein. The team will breed mice that have one copy of each gene. These mo...Other highlights in the August 18 JNCI
...found evidence of a prostate cancer susceptibility gene on the long arm of chromosome 17. In addition, fou...nd Men who carry a specific mutation in the MIC-1 gene may have a lower risk of developing prostate cancer than men who do not have the mutation, according...Tips from the journals of the American Society for Microbiology
...the researchers. In the study researchers compared gene expression in the gingiva and spleens of two mouse...givalis. Following infection, spleen and gingival gene expression indicating susceptibility (genes Il1b, Tnf, and Stat6) increased in the susceptible gro...Stanford researcher's findings may shed light on common, deadly birth defect
...l Helms, DDS, PhD. "We thought that uncovering the gene or genes responsible for the condition might answer the question, but in many cases that has only added more confusion." Helms, an associate professor in plastic and reconstructive surgery, recently came to Stanford from UCSF, where the current work ...Gene duplication allowed pigs to have more babies
...formation to estimate that the ancestral aromatase gene duplicated twice, to give three genes, between 27 ...ases, one more than most hooved animals, the first gene duplication is likely to have occurred in the common ancestor of the three animals, around 35 millio...X marks the spot: Vector insertion is viral specific
...n vehicles for delivering therapeutic payloads via gene therapy in animal models of disease and human pati...into active genes may help promote efficient viral gene expression. The reason for the choice of target is less clear in other retroviruses. These...Rare mutations can significantly increase risk factor for heart disease
Certain rare gene mutations can contribute significantly to low leve...nted to know," Hobbs said, "was how much do single gene defects with major effects contribute to complex traits?" Although mutations with such a strong eff...Retroviral gene therapy? ASLV, HIV, and MLV show distinct target site preferences
...c fibrosis to cancer) have a genetic component and gene therapy holds the promise of restoring compromised...sorder died after participating in an experimental gene therapy trial in 1999. In another case, two young boys who received gene therapy for the severe immu...Protective gene may enhance vaccine responses
... 15 -- the researchers show that activation of the gene for the Serine protease inhibitor 2A (Spi2A) can prevent the death of T cells during the contraction phase, resulting in about five times as many memory T cells. "Drugs based on protective factors such as Spi2A could provide an enormous boost to vacc...Ovarian cancer sheds tumor suppression with loss of estrogen receptor
...d the ovarian cells during cancer progression, the gene for ER beta was replaced in ovarian cancer cell li...bility to decrease the expression of the cyclin D1 gene was completely opposite of it's counterpart, ER beta. Furthermore, the restored ER beta induced apop...Prions act as stepping stones in evolution
...sections of DNA that indicate exactly where in the gene a particular protein recipe ends. Sup35 ensures that the cell only translates material prior to these designated codons. But when it misfolds into a prion conformation, Sup35 gets sloppy, and the cell reads beyond the stop codons, translating geneti...Last of known genes identified in complex obesity syndrome
...iabetes and asthma. The identification of the BBS3 gene ends the search for primary BBS-causing genes in f...international team reports that BBS3 is actually a gene formerly known as ARL6. Importantly, ARL6 is the first BBS culprit to belong to a family of genes an...Schizophrenia gene variant linked to risk traits
...iated with schizophrenia. The finding confirms the gene responsible for management of glutamate is a promi... long thought to play a role in schizophrenia. The gene identified in this study makes the glutamate receptor (GRM3) which is responsible for regulating glu...Gene changes linked to increased eye pressure may have implications for glaucoma therapy
...x Gla protein (MGP) and perlecan. In addition, the gene for spectrin, a protein that alters cell shape, was switched off. MGP prevents the hardening of cartilage to bone, and perlecan has been implicated in allowing tissue to withstand compression, Borrs said. Spectrin helps maintain cell shape. Thus...Jefferson Lab detector technology aids development of cystic fibrosis therapy
...al imager that's helping researchers develop a new gene therapy technique for cystic fibrosis. "Our ...the small animal medical imager in cystic fibrosis gene therapy studies along with colleagues Assem Ziady and Pamela Davis. They're researching a new way to...