Tag: "gene" at biology news

Transcriptional gene silencing in nucleus shown by UCSD/VA medical researchers

...are System. The technique, called transcriptional gene silencing (TGS), provides a new research tool to study gene function and, if continuing studies prove the concept, it could potentially become a method for ther...

Outcome for acute lymphoblastic leukemia linked to gene expression patterns

...fferent treatment protocol at St. Jude. "The gene expression patterns linked to drug resistance were... found that there is no universal cross-resistance gene that would block sensitivity to all four drugs. Rather, genes linked to resistance belonged to diffe...

Other highlights in the August 4 JNCI

...t cancer patients with tumors that overexpress the gene HER-2/neu are more likely to have a poor clinical outcome. A new study finds that HER-2/neu overexpression does not lead to a poorer response to chemotherapy in women with metastatic breast cancer. There is some evidence that HER-2/neu overexpression...

JCI table of contents, 2 August, 2004

...egulated by selective targeting of skeletal muscle gene products AUTHOR CONTACT: Denis C. Guttridge The Ohio State University College of Medicine, 420 W. Twelfth Ave. Columbus, OH 43210, USA Phone: 614-688-3137; Fax: 614-688-4006; E-mail: guttridge-1@medctr.osu.edu View the PDF of this article at: htt...

Genetic discovery could dramatically reduce need for liver transplants in children

...f livers of 14 infants with biliary atresia. Using gene chip technology, he and the Cincinnati Children's ...unique mouse model of biliary atresia in which one gene produced by inflammatory cells was inactivated. He found that by blocking in mice the same inflammat...

'Smart gene therapy' protects against damage from heart attack

...51; Early intervention with a novel kind of "smart gene therapy" might effectively prevent the organ damag...Medical Center. The therapy combines a therapeutic gene with a genetic "sensor" that recognizes and responds to the oxygen deprivation that follows the redu...

New technique helps scientists reveal interactions between genes and drugs

...scientists they need to look near the marker for a gene that changes sensitivity. The initial test o...now, so we're definitely going to be looking for a gene that affects sensitivity in this region." McLeod's group already has applied the new screening t...

Malignant cancer cells generate mice through cloning

...omponents, such as methylation, can determine if a gene is silent or active. Konrad Hochedlinger and Robert Blelloch, postdoctoral researchers in the Jaenisch lab, studied whether any of these epigenetic influences can be reversed. First, they removed the nucleus from a melanoma cell and injected it int...

Clusters of alterations on PIK3CA gene found in brain cancers

Hotspots in two areas of a gene that encodes a specific signaling enzyme, or kinas...of the journal Cancer Research . Mutations in the gene PIK3CA occur spontaneously as part of the brain tumor development rather than being passed genetical...

DNA variations surprise researchers

...0 per cent of these alterations lead to changes in gene numbers and at least 14 regions overlapped with kn... shows that some people may have 10 copies of this gene while others may have as much as 24 copies of this same gene. It would be really exciting if we foun...

In search of a lean gene

...e obesity epidemic, analyzing the effects of C/EBP gene replacement in mice. The C/EBP protein family cons...e physiological impact of replacing the C/EBPalpha gene with the C/EBPbeta gene. "No doubt, C/EBPalpha is very important for life as indicated by many exce...

LA BioMed Medical/Research Briefs, July/August 2004

...ize information and view it through a new lens The gene pools of contemporary species have evolved not by chance, but through the process of natural selection. Therefore, we should be thinking about how to exploit this process in order to discern gene-selection patterns based on function, that is, through...

Study finds anti-HIV protein evolved millions of years before the emergence of AIDS

...s known as positive selection, indicating that the gene has been under pressure to evolve throughout history. But lentiviruses the family of viruses to which HIV belongs have been found in only some of the primates studied and appear to be at most 1 million years old. "What is novel about our findings i...

The beak of the squid

... and--in its best-studied mode of action--quashing gene expression by cleaving messenger RNA. Experimental...plications of RNAi have spurred the exploration of gene function in many basic research, drug discovery, and clinical settings. Until now, however, the iden...

Study reveals surprising 'remodeling' property of gene regulation process

...a nucleosome is moved from a site, the appropriate gene then can be expressed much more efficiently. The n...n. The UNC researchers also discovered that when a gene needs to be turned off, the cell recruits the nucleosomes back to a particular location in the genom...

Brookhaven lab biophysicist F. William Studier wins R&D 100 award

...s the production of proteins in the widely used T7 gene expression system. The T7 expression system, developed and patented at Brookhaven Lab in the 1980s and 1990s, is used worldwide by academia and industry to produce specific proteins within bacterial cells. R&D 100 Awards are given annually by R&D Ma...

Casanova or caveman: Scientists isolate nerve cells that choreograph male fly's courtship behavior

...d graduate student Devanand S. Manoli focused on a gene known as fruitless - one of approximately 13,000 g...reviously discovered that fruitless was the master gene that controlled sexual behavior in male flies. "We found that the fruitless gene was responsible for...

UCI study reveals gene linked to breast cancer can suppress tumors

...has found a novel tumor- suppressor function for a gene that, when mutated, often triggers breast cancer i...ancer Center have identified how the healthy BRCA1 gene prevents the growth and survival of breast cancer cells. The gene accomplishes this by keeping estro...

UNC researchers awarded $8.65 million from National Institute on Aging

...ng how these molecules are involved in DNA damage, gene expression and atherosclerosis. Dr. David Clemmons, professor of medicine and biochemistry and biophysics, is the grant's principal investigator. He also is director of the endocrinology division in the department of medicine and is recogniz...

Environment influences learning: U of T study

...'ve learned. The next step is to find the specific gene involved in processing environmental cues, says Law. Once it is identified, researchers will be able to search for similar genes in humans in order to shed light on the workings of human memory. This study was supported by the National Sciences and ...

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