European common frog found to use novel mating strategy
...m, The Netherlands, he analyzed the tissue samples genetically to show that clutch piracy leads to a greater percentage of fertilized eggs in the clutch, as well as clutches with as many as four fathers. Vieites noted that this unusual mating strategy is a good way for the frog population to ensure that as many ...Genetically modified bacterium as remedy for intestinal diseases
...he fight against chronic intestinal disease with a genetically modified bacterium (Lactococcus lactis). The modif...simple manner. The researchers have shown that the genetically modified bacterium is able to manufacture the potential medicine, Trefoil Factors, in the intestines...Can an old gene learn new tricks?
...sophila. The researchers found that when mice are genetically engineered to lack Hmx2 and Hmx3, Drosophila Hmx can substitute for the mouse Hmx3 gene in CNS development and, surprisingly, can also direct development of the inner ear. Therefore, a Drosophila gene can direct formation of an organ system that doe...Protein is key for digestive function of the pancreas
... granules. The researchers studied mice that were genetically designed to be missing VAMP8 and found that the mice had pronounced pancreatic defects. Pancreatic acinar cells lacking VAMP8 had many more zymogen granules than control acinar cells. In addition, CCK did not stimulate exocytosis in VAMP8-deficient...Proteins show promise for mosquito control
... that there are many uncertainties about releasing genetically modified organisms into the environment. Lan believes that a more fine-tuned chemical approach is more practical: only one compound is selected, it works for a short period, and it targets a single insect. "People might ask, 'Why do we need more pe...Joslin President awarded medal from international diabetes organization
...olleagues have conducted a series of studies using genetically engineered mice with knocked out insulin receptors in classical target tissues, such as liver, muscle and fat. These experiments indicated the important link between obesity, diabetes and longevity. Using these techniques, Dr. Kahn and colleagues i...OutFoxed! New research may redefine late-stage cardiac development
...ther develops into the four-chamber heart. Using genetically engineered mice, Penn researchers successfully inactivated the Foxp4 binding protein, which resulted in the inability of the bilateral tubes to fuse. They found that each region of pre-cardiac cells still developed into a single tube, and then furthe...Fossils reveal direct link between global warming and genetic diversity in wildlife
...ow did individual voles and pocket gophers respond genetically to these episodes of global warming and cooling? ...r Yellowstone ecosystem who are trying to maintain genetically diverse populations of elk, bison and other mammals. "The landscape of Yellowstone arguably one of...Common cold virus can cause polio in mice when injected into muscles
...inds to the CD155 receptor. However, the mice were genetically engineered to have only the Coxsackie A21 receptor...1 is one of a large group of cold viruses that are genetically very similar to polioviruses. "Our study reveals how similar these viruses actually are," he said. "...Genetic map of important tree genes outlined
...ich is a large part of the unease about the use of genetically engineered crops in agriculture, Strauss said. The researchers in their new report pointed to trees as "a life form of paramount importance for terrestrial ecosystems and human societies," because of their ecological dominance and provision of so muc...Bone marrow cells routinely help with wound healing
...e and then performed a stem cell transplant into a genetically identical strain of normal mice, whose cells do not glow green. Afterward, only the bone marrow of the transplanted mice glowed green inside the bodies of the mice, allowing researchers to track the bone marrow cells throughout the body. Researchers ...Diabodies act as guided missiles targeted to mammary tumor growth
... Cancer Center, Philadelphia, Pa. Diabodies are genetically engineered dimeric proteins produced in E. coli ba...es are so much smaller than native antibodies, the genetically engineered protein is cleared much quicker from the body, Adams said. However, the affinity that the...Study reveals first genetic step necessary for prostate cancer growth
...esearchers developed a system using mice that were genetically engineered to self-destruct one or both copies of ...n't had before." Greenberg developed a widely used genetically engineered strain of mice that develops prostate cancer at the Baylor College of Medicine prior to j...New imaging technology at Joslin shown to detect early signs of type 1 diabetes
...ology might someday be used in individuals who are genetically at risk for diabetes to detect this autoimmune process in its earliest stages," Dr. Benoist suggests....JCI table of contents: 1 September, 2004
...his paradox, Patrick Bertolino and colleagues used genetically altered mice models that specifically express immune-reactive substrates called antigens in either the liver cells or the hepatic lymph nodes to examine the mechanisms that mediate these paradoxical activities. The authors found that when antigen was...Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
...f a genetic link to schizophrenia. The researchers genetically engineered mice with a mutation in the gene NPAS3 , a mutation in the gene NPAS1 or a mutation in both genes. Both genes encode proteins that switch other genes on and off in brain cells. "These mice display certain deficits that are potentially ...Highlights of American Chemical Society national meeting in Philadelphia, Aug. 22-26
...uld lead to more flavorful strawberries as well as genetically engineered hybrid fruits with unique flavors and aromas, they say. The presentation is part of a two-day symposium, "Genetic Engineering in Flavor Chemistry," held Aug. 22-23. ( AGFD 15 , Sunday, Aug. 22, 10:10 a.m., Courtyard by Marriott, Room 102) ...Streptococcus infects humans by thwarting blood clotting
...tle activity against other mammals. The scientists genetically altered strains of mice to make the animals susceptible to infection by streptococcus. They say their strategy outlines a new path for developing animal models for human-specific microbes. The research is also likely to open the way to new understand...Strep disrupts blood clotting to infect humans
...M postdoctoral fellow Hongmin Sun had to develop a genetically engineering humanized mouse that made significant amounts of human plasminogen to test the researchers' ideas about group A streptococci. Ginsburg adds that making this mouse susceptible to human-type streptococcus infection may represent a significa...Columbia, Stony Brook, Guidant to develop biological pacemaker based on gene & cell therapies
...ted that adult human mesenchymal stem cells can be genetically engineered to express a specific gene responsible for the normal pacemaker function of heart cells. These cells are not embryonic and are obtained from adults. The researchers have shown that when cells engineered in this way are placed in a specif...