New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine
...ossible to identify an alternative cell line or to genetically modify the Vero E6 cell line by altering its glycosylation pathway, thereby producing vaccines with enhanced efficacy without autoimmunogenic activity." Wang and Lu note that the experimental approaches developed in their research are likely applica...Firefly compound lights up 'protein dance' in living animals
...oteins interacting in live animals. The technique genetically fuses proteins of interest with carefully cleaved ... best. In a line of experimental mice, scientists genetically fused one member of the best pair of luciferase fragments onto the protein targeted by rapamycin, at...LICR/UCSD team solves mystery of centromeres
...ch more rigid than similar regions of H3. He then genetically "transplanted" this small, stiff region of CENP-A into H3, and found that the "stiffened-up" H3 acted just like CENP-A, binding to centromeres. "With DXMS, we were able to find the small region within CENP-A responsible for its ability to ...DNA tests point to extinction of 2 distinctive arctic bird populations
...d the other in Alaska's Aleutian Island chain are genetically distinct from all other rock ptarmigan and should be considered separate species. "Traditional classifications often fail to capture the diversity and evolutionary history of organisms below the level of species," Dr. Montgomerie explains. "If we con...Plant respiration not just an evolutionary leftover, study shows
... no longer necessary. Some have even set about to genetically engineer crop plants so that the activity of the enzyme that initiates both the light-independent reactions of photosynthesis and photorespiration would favor photosynthesis to a greater extent and minimize photorespiration. The result, they have th...Scientists discover new intricacies in how ulcer bugs stick to stomach
...endency over the course of multiple generations to genetically deactivate and reactivate babA proteins that allow them to stick to the stomach lining, and that during these cycles the ability to bind to other forms of Lewis b may have been lost," Berg explains. The ability to turn these proteins off insu...West Nile takes its toll on rare bird
...s. Trying to improve habitats that support robust, genetically diverse populations may be one way to try protect the bird, said Aldridge. Revisiting mosquito control programs may be another way to tackle the problem, but may only be a temporary band-aid solution. When a species is placed on an endange...Symposium to tackle questions of genetic engineering and biodiversity
MINNEAPOLIS / ST. PAUL-- How might genetically engineered organisms (GEOs) help restore threatened habitats? What are the ecological risks associated with the introduction of GEOs for conservation purposes? And how might the role of conservation biologists be changing in the new era of "genetic r...Gene expression patterns may help predict risk and progression of prostate cancer
...gues used high throughput quantitative analysis to genetically profile prostate cancer tissue and noncancerous pr...ee tissue. Furthermore, the adjacent tissue was so genetically altered that it resembled a cancer field effect, undergoing genetic changes similar to prostate canc...Society for conservation biology conference
...a large freeway in southern California have formed genetically distinct sub-populations, suggesting that little mixing occurs. With Climate Change, Will Species Leave Parks Behind? A number of presentations will address the future of national parks and other protected areas as animals and plants migrate in res...Lack of immune system protein prevents lupus-like condition in mice
...5 issue of the Journal of Experimental Medicine, a genetically modified line of mice continued to be fit even after pristane exposure. Created by National Institutes of Health researcher and coauthor Pamela L. Schwartzberg, the mice lack the SAP gene. "The mice appear to be generally healthy," Peng says. "They h...OHSU scientists find gene influencing drug withdrawal
... more evidence that drug and alcohol dependency is genetically determined. Previous OHSU studies have shown that ...re susceptibility in general because its status is genetically correlated with seizures induced by some, but not all, drugs. "There are a lot of questions to pursu...Study supports association between HPV infection and head and neck cancer
...rt the idea that HNSCCs can be subdivided into two genetically distinct categories and that HPV infection is involved in the early development of some HNSCCs, according to the authors. "Our results are consistent with the hypothesis that HNSCCs develop by two different etiologies: one driven by exposure to envir...The amendment to the law on green Genetic Engineering inhibits innovation and research in Germany
...k is automatically attached to the introduction of genetically modified organisms (GMOs). In the opinion of the D... The draft amendment also intends to hold users of genetically modified organisms responsible for "intrusion" by GMOs into conventionally or ecologically produced ...RICE gets $1.1m from DOD to study neurofibromatosis
...e in a model system, an organism that is much more genetically tractable than humans," said Michael Stern, professor of biochemistry and cell biology at Rice University. "We've developed a fruit fly model for neurofibromatosis that we're using to identify key proteins that regulate NF in humans. Ultimately, we h...UNC research accelerates discovery of novel gene function
...culture to the animal model." The technique uses a genetically engineered HIV-1 virus, in which genes can be shuttled among bacteria, cell culture or animal models, in the same vehicle, or vector. This avoids time-consuming methods involved in gene isolation and amplification, such as the polymerase chain reacti...Macrophages, not stem cells, correct liver disease by fusion
...ture studies will even look at whether they can be genetically modified before transplantation. "That's the future. That's what we're trying to do," he said. As for stem cell plasticity, Grompe said he and his colleagues "just don't see it," at least in liver cell repopulation. "That could mean two things: We're......tack and in doing so have highlighted the value of genetically modifying plants for the study of complex ecologic...tion of the herbivore community, which was made by genetically silencing different components of a signaling pathway that mediates induced resistance in a native p...Therapeutic cloning no longer a dream, says scientist who produced first cloned embryonic stem cell
...e of its potential to produce stem cells which are genetically identical to the donor. In principle stem cells can be directed to develop into any tissue. "This means that patients who received them as part of a treatment would not reject the cells as foreign", said Professor Moon. "We call this therapeuti...Bacteria spill their guts to aid researchers in quest for new antibiotics
...veral sites within the protein that, when modified genetically and chemically, can cause the channel to open inappropriately, thus killing the organism," Dr. Blount said. "If these regions of the protein could be modified pharmacologically, one may have the makings of an antimicrobial agent." The membrane protei...