JCI table of contents, 2 August, 2004
...f cells into the bile ducts was blocked. However, giving the mice interferon-gamma following infection resulted in bile duct blockage. These data identify interferon-gamma as a key player underlying this deadly condition in children and suggest potential new investigative and therapeutic directions for the...Ottawa's leadership in biomedical and health research has paid off
...lved in the research enterprise. Together, we are giving Canada the tools and facilities required to compete in research on the world stage." The challenge for the new federal government is to develop and implement a mechanism to continue this commitment so that Canada can grow as a leader of international...Gene therapy reaches muscles throughout the body and reverses muscular dystrophy in animal model
...e the victim cannot survive. "By giving one single injection of this AAV vector carrying a mini-dystrophin gene into the bloodstream, we are able to deliver therapeutic levels of dystrophin to every skeletal and cardiac muscle of an adult, dystrophic mouse," Chamberlain said. "These muscle...Bone, enamel, dentine, milk & saliva share gene family
... fugu fish data to confirm that the databases were giving us the correct results," says Kawasaki. The researchers used messenger RNA, the substance that contains the information for producing proteins to reverse engineer DNA that codes for these proteins. This copy DNA can be used to locate the original g...Good bacteria trigger proteins to protect the gut
...r unexpected findings suggest that the practice of giving antibiotics to cancer patients to prevent infections might render the gut more vulnerable to damage a danger that might be overcome by administering substances that mimic the protective presence of gut bacteria. The findings may also revise thinking...Plant respiration not just an evolutionary leftover, study shows
...bon dioxide into sugars that fuel the plant, while giving off oxygen. Though elegantly simple in concept, this process, known as photosynthesis, is remarkably complex in detail. And for years, researchers have been puzzled by another process, photorespiration, which seems to have annoyingly associated with...University of Pittsburgh medical center among first to implant heart assist device
...E has been developed to be a viable therapy and is giving new hope to people," said Dennis McNamara, M.D., associate professor of medicine at the University of Pittsburgh School of Medicine and director of the Heart Failure/Transplantation Program at the UPMC Cardiovascular Institute. "As the technology imp...Drug prevents chemotherapy-induced hearing loss, study finds
...toxicity "one of the main dose-limiting factors in giving cisplatin." "Cisplatin is given a lot. It's been around a long time, and it's very effective. But it's very toxic," Dickey said. Cisplatin is administered intravenously to slow or stop the growth of cancer cells. In addition to head and neck cancers,...Scientists identify molecular link driving spread of skin cancer
...ydrates that extend outward from its protein core, giving it a structure similar to a bottle brush. Carbohydrate side chains, called glycosaminoglycans (GAGs), can interact with other molecules outside of the cell wall membrane. CD44 is produced by cells and positioned on their cell surface membrane. It i...New drug shows promise against Gleevec resistance in mice
...time, Sawyers's musings became more public. "I was giving scientific talks on the structural implications of Gleevec mutations and stating that I thought that a Src inhibitor would be a good idea," said Sawyers. "This was an informed guess based on what we were seeing in the crystallography data." ...'Extinct' bird rediscovered in Mexico
...iversity conservation, and the importance of never giving up on a species - no matter how rare," said Dr. Russell Mittermeier, president of Conservation International. Although the hurricanes are believed to have had a major negative impact on the birds, scientists believe that other factors must have cont...Access to DNA secrets yields better understanding of genes, possible tool for disease diagnosis
...July 8, 2004 A new technique for examining DNA is giving scientists a more detailed picture of which genes have the propensity for activation, offering a new tool for understanding how genes function and possibly for diagnosing disease. The technology, called a chromatin array, was developed by researchers......f relatively old people likely had a major impact, giving modern humans a competitive edge that ensured their evolutionary success. For the study, the researchers analyzed the ratio of older to younger adults in hominid dental samples from successive time periods: later australopithecines, Early and Middle ...Endometriosis: Could angiostatic therapy be the new treatment of the future?
...atic to suppress the patient's hormones, either by giving an oral contraceptive pill or gonadotrophin releasing hormone (GnRH) analogues. These patients definitely will not be able to conceive under that medication. With endostatin, however, it would be possible to become pregnant. "Results from this stud...$5 million grant funds partnership, studies of minority-based issues in reproductive health
...e whether physicians should change the practice of giving birth control pills to women who have abnormal bleeding because of fibroids. Additionally, the study will investigate whether African-American women, who more commonly have fibroids than women of other races, have higher levels of female sex hormones...Antioxidants during pregnancy may help prevent birth defects tied to alcohol
...dy unique is that it shows for the first time that giving antioxidants to a pregnant mother at the same time she's exposed to alcohol can diminish the incidence of major malformations," said Dr. Kathleen K. Sulik, professor of cell and developmental biology at UNC's School of Medicine. Antioxida...NIH launches first center in Nationwide Chemical Genomics Network
... Collins, M.D., Ph.D. "What we are doing is simply giving academic and government researchers a chance to contribute in a much more vigorous way to the earliest stages of the drug development pipeline: the identification of useful biological targets. This is a win-win situation for basic biology, for the dr...2004 BP Conservation Programme winners pave the way for protecting wildlife
...onservation Programme is proud to say that through giving small amounts of money to young enthusiastic students, over 85% of those who are supported by the programme go on to work in the fields of conservation and development; and projects initiated by these students in an overwhelming number of cases conti...Novel therapeutic bortezomib moves to phase II trial in lung cancer patients
...l research at UC Davis Cancer Center suggests that giving bortezomib last may be more effective than giving it first or at the same time. Bortezomib is a proteasome inhibitor that blocks the signals cancer ce...When combining new oral anti-cancer agents with standard chemotherapy, timing may be crucial
...n-small cell lung cancer cells. "We predicted that giving docetaxel first, then erlotinib, would be more effective than giving the erlotinib first, giving both drugs simultaneously or giving either drug alone" Gumerlock said. "...