Alzheimer's disease is not accelerated aging
...ions of the brain that undergo atrophy and reduced glucose metabolism, and appear to be involved in memory impairment. "We see profound disturbances in the medial temporal lobe memory system across methods--in studies of volume, function, and now showing what we think is the pathology in Alzheimer's disease,...Joslin Diabetes Center honors brothers living 70-plus years with type 1 diabetes
...be commended for meticulously managing their blood glucose levels day in and day out for several decades. They serve as an inspiration for anyone living with type 1 diabetes." Robert Cleveland is a retired accountant and has two children, Marilyn Welles and Neil Cleveland, with Ruth Cleveland, his wife of...A novel, safer strategy for regulating gene expression
...dy for example, in a diabetic patient, a rise in glucose concentration would automatically turn on the gene responsible for insulin production. The system, described in a proof-of-principle paper in the Sept. 23 edition of the journal Nature, is simpler than current methods of gene regulation, and the te...New way to protect brain from stroke damage
...e. The normal brain requires complete oxidation of glucose to fulfill its energy requirements, the researchers explained. During ischemia, oxygen depletion forces the brain to obtain energy through anaerobic glycolysis, a process which results in the accumulation of lactic acid. Earlier work indicated that s...Joslin researchers clarify mechanisms for beta-cell formation
...ulin to function properly, including keeping blood glucose levels in the normal range. It is a major contributor to type 2 diabetes, obesity and the metabolic syndrome, which affect nearly one-quarter of the American population. For years, the body compensates for insulin resistance in order to delay th...Peering inside the body, with a new spinliterally
...ns and the components at work in them such as fat, glucose and other metabolites," said Robert Wind, a physicist and laboratory fellow at the Department of Energy's Pacific Northwest National Laboratory, and slow-spin technique inventor. "We think this new technique can be used to diagnose diseases and asses...Research on carbohydrate metabolism receives historical recognition
...erty Cori exploring how the human body metabolizes glucose will be designated a National Historic Chemical La...ori cycle," the process by which the body converts glucose into glycogen, the form in which sugar is stored. They isolated and purified many of the enzymes inv...Other highlights in the September 1 JNCI
...which transport these molecules. Cells deprived of glucose accumulate unfolded proteins, but such cells survive this stress by turning on a special molecular pathway--the unfolded protein response--that protects cells from the harmful effects of unfolded proteins. Researchers have hypothesized that glucose-d...Decreasing toxins in brains of Alzheimer's patients keep cognitive deficits at bay
...e. Additionally, the normal components of CSF like glucose and immunoglobulins did not change after the shunt was placed in patients. The shunt has a selective capacity to filter out toxins of a specific molecular weight and size, in this case isoprostanes. Applying a treatment for hydrocephalus to Alzheimer...Engineering endurance: The future of the Olympics?
...nd which energy-producing substrates (for example, glucose or fatty acids) are used; it also generates metabo...levels of gene transcripts and enzymes involved in glucose transport and metabolism. In the mutant mice, expression of these glycolysis associated genes and en...Genetically-engineered 'marathon mouse' keeps on running
...er mitochondria, and must derive their energy from glucose instead of fat. As a result, these muscle fibers fatigue quickly. Until the production of the genetically altered mouse, the only known way to increase endurance was through physical training. "We thought that the enhanced PPAR-delta would just enab...Nevada researcher re-ignites mammal reproduction debate
... offspring. Body fat and diet can affect levels of glucose circulating in a mammal's body, and Cameron suggests that the levels of glucose around the time of conception could be influencing the sex of the animal's offspring. "A high-fat ...Putting energy into heart protection
...se energy and by turning on processes that take up glucose and free fatty acids from their surroundings in or...ice without a functioning AMPK could not stimulate glucose uptake, although the molecular mechanisms for glucose uptake were intact, nor did they breakdown fat...JCI table of contents, 16 August, 2004
...se energy and by turning on processes that take up glucose and free fatty acids from their surroundings in or...ice without a functioning AMPK could not stimulate glucose uptake, although the molecular mechanisms for glucose uptake were intact, nor did they breakdown fat...Joslin Diabetes Center launches research section on developmental and stem cell biology
...ratory has shown that pathways activated by excess glucose metabolism are responsible for the effects of diab...biochemical and molecular mechanisms by which high glucose and oxidative stress prevent the activation of embryonic genes. If oxidative stress plays a signific...Other highlights in the August 4 JNCI
... syndrome, which is also characterized by obesity, glucose intolerance, and hypertension. Both metabolic syndrome and breast cancer have been increasing worldwide. Increased levels of insulin and insulin-like growth factor in metabolic syndrome have been linked to breast cancer, but the role of other biomark...JCI table of contents, 2 August, 2004
...S ISSUE Sugar Baby Lacks Control TITLE: Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM AUTHOR CONTACT: Gavin Kelsey The Babraham Institute, Cambridge CB2 4AT, UK Phone: 44-1223-496332; Fax: 44-1223-496022; E-mail: gavin.kelsey@bbsrc.......t cells become resistant to insulin, causing blood glucose levels to rise and eventually damage nerves and blood vessels. Dr. Roger Davis and colleagues in the Howard Hughes Medical Institute at UMASS Medical School focused their research effort on the JNK (pronounced "junk") family of kinase enzymes. JNK a...Misfiring proteins tied to inflammation and sick feeling of type 2 diabetics
...nside. When that happens, the ability to regulate glucose levels is compromised. A mechanism thought to be ..., improves insulin signaling and insulin-dependent glucose uptake in skeletal muscle in mice and speeds recovery from lipopolysaccharide-induced sickness behav......blood insulin, leptin and triglyceride levels, and glucose tolerance were improved. Calcium balance was not a...ulin levels, as previously described, and improved glucose tolerance. As the isocaloric exchange between high and low protein diets was performed on carbohydra...