Tag: "glycosylation" at biology news
Jefferson Scientists Devise Way To Treat Animals Chronically Infected With Hepatitis B
...ains."It works by inhibiting the first step in the glycosylation
process that allcell glycoproteins go through to reproduce and be able to infect. We discoveredthat the host cellular glycoproteins appear to be far less sensitive to thisinhibition than is HBV. "We were able to inhibit this step in glyco-pro...
Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory
...the drug worked by inhibiting the firststep in the glycosylation
process that all cell glycoproteins go through toreproduce and be able to infect. The host cellular glycoproteins appear to befar less sensitive to this inhibition than is HBV. BVDV and HCV are viruses composed of RNA, as opposed to HBV, whic...
Novel route to lupus-like disease in mice
...ders. "However, it wasn't known whether changes in glycosylation
cause autoimmune disorders," said Marth. Past ef... do not appear." To determine whether defects in glycosylation
play a role in autoimmune responses, Marth and his colleagues knocked out the gene in mice that prod...
Virus studies reunite two families of major insect-borne viruses
...of the virus, genetically altered to eliminate the glycosylation
sites, that allowed them to study general surface ...lized they could use the mutant viruses to map the glycosylation
sites, providing a rare opportunity to analyze the structures of the two major proteins involved, ca...
Scientists close in on trigger of insulin resistance
...iabetes. The results underscore the importance of glycosylation
attachment of a sugar to a protein -- as a way ce...ggest. "Textbooks frequently and incorrectly show glycosylation
only happening to proteins on the cell surface," says Hart. "Complex sugars are added only to protei...
Researchers identify defect that causes rare muscular dystrophies
... involved in the biochemical pathway that leads to glycosylation
of dystroglycan. Additional evidence for the importance of dystroglycan glycosylation
came when first author Daniel E. Michele, and his colleagues discovered that a commonly used mouse m...
University of New Hampshire launches biomedical research network with $5.6 million grant
...ms biology." Reinhold's own research on molecular glycosylation
in cell biology is a perfect example. He is currently collaborating with researchers around the world on projects relating to heart disease, gonorrhea, and the immunity-conferring properties of human milk, among others. NH-BRIN is already supporting...
Tailor-made sugar coated proteins manufactured in novel E. coli system
...ult process. The addition of sugars to proteins by glycosylation
is crucial in defining their job in the body by he...ssess the same type of cellular machinery used for glycosylation
in higher organisms like humans. Until now this has restricted the types of human proteins that can ...
Dartmouth engineers closer to mass-producing therapeutic proteins
...ting for the first time the production of 'hybrid' glycosylation
structures in yeast brings GlycoFi an important st...of proteins in humans. After eliminating non-human glycosylation
from the yeast, several genes were inserted into the yeast in such a way that the yeast synthesized ...
First production of a human protein with complex glycosylation in genetically modified yeast
...s with complex sugar molecules a process known as glycosylation
has been the main obstacle that has prevented the...College report the successful reengineering of the glycosylation
pathway in the yeast Pichia pastoris. Published in the latest issue of Science, these results const...
New roles for protein modifications in cell migration
...trated the role of a protein modification known as glycosylation
in guiding the migration of gonadal cells in the n...o (Canada), is the first to reveal the function of glycosylation
in the action of an ADAM-family protease, a finding of potential significance to the study and treat...
World's leading 'mad cow' diagnostic company, responds to USDAs additional BSE protection measures
...c three-band pattern of the protein reflecting its glycosylation
status. Prionics-Check WESTERN is also the only recommended test for highly compromised tissue samples. Prionics' surveillance concept led to the establishment of official EU-wide BSE screening programs in 2001, and the Prionics-Check WESTERN is th...
Protein-centric drug development and functional glycomics enrich biopharmaceuticals pipeline
... provides a better understanding of glycoproteins, glycosylation
process, and its role in the protein function," explains Frost & Sullivan Industry Analyst Giridhar Rao. "This in turn facilitates the development of novel biodrugs." The rapid progress of glycomics in the biopharmaceutical industry is evident from ...
U. Iowa muscular dystrophy discovery may lead to new treatment approaches
... to a critical muscle protein that is disrupted by glycosylation
(sugar-adding) defects in several different human ...ar dystrophies and other muscle diseases caused by glycosylation
defects. A group of muscular dystrophies, which include Fukuyama Congenital Muscular Dystrophy, Wa...
LARGE protein can overcome defects in some types of muscular dystrophy
... the cells had lacked the normal sugar groups, but glycosylation
was restored when the LARGE gene was expressed. "W...e cell types had a mutation in a different enzyme, glycosylation
was similarly increased in all three, suggesting that increasing LARGE levels could be helpful regar...
New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine
...cally modify the Vero E6 cell line by altering its glycosylation
pathway, thereby producing vaccines with enhanced ...t that the species-associated variation in protein glycosylation
might result in significant differences in sugar chain expression by the SARS viruses. To clarify wh...
The first engineering of cell surfaces in living animals
...njected into organs to seek out cells with certain glycosylation
patterns" -- patterns of cell-surface sugars characteristic of cancerous cells, for example, or sites of inflammation. Not only does the demonstration of the Staudinger ligation in mice suggest a range of diagnostic and therapeutic possibilities, th...
Sweet success in targeting sugar molecules to cells in living animals
...ups to a molecule. It has long been known that the glycosylation
patterns of sugar molecules on cell surfaces can i...that cancer cells, for example, exhibit changes in glycosylation
patterns when compared with their normal healthy tissue counterparts," said Bertozzi. "And there are...