Genetic mutation found that is major contributor to type 1 diabetes
...uthor on the study. "The mutation we have found is going to increase the responsive capacity of the immune ...iabetes and, perhaps even more, for people who are going to develop diabetes." He noted that none of the work would be possible without the contributions of ...Lack of immune system protein prevents lupus-like condition in mice
...fferent facet of the human disease. It's therefore going to be very interesting to test if this is a finding that can apply to lupus generally or if it is limited to a subset of lupus," Peng says. Based on how thoroughly SAP's removal appears to disrupt T and B cell interactions, which are essential to pro...U of T microbiologists achieve results with pattern recognition software
...echnique to predict the function of yeast genes is going to become a classical example of how to do this in biology." To create each mutated strain, the researchers used a technique in which adding the drug doxycycline to the yeast cells disables an individual gene. This technique is a reliable alternative...Protein controls acid in cells by direct detection of volume changes, study finds
... very acidic. As the body's normal metabolism gets going again, the NHE1 system starts pumping out the accumulated acid, exchanging the acid for sodium. "It's such an active system that you can overload the cell with sodium," Dr. Hilgemann said. "Too much sodium is a major mechanism of cell death in ischem...Severe depression associated with greater number of nerve cells in thalamus region of brain
...l way. "But if their brains are different, they're going to behave differently. Depression is an emotional disorder. So it makes sense that the part of the brain that is involved in emotional regulation is physically different." Four groups were represented in the study: subjects with major depression, wit...Donaghue Women's Health Investigator Program awards grants to three at Yale
...ssions we evaluated speaks to the significant work going on at Yale, and to the desire on the part of researchers to factor gender into their investigations in order to improve outcomes," said Carolyn M. Mazure, director of Women's Health Research at Yale. "Our program's research agenda is designed to gen...Therapeutic cloning no longer a dream, says scientist who produced first cloned embryonic stem cell
... We do not know whether this was due to something going wrong in the development of the cloned embryo, or whether we need to make small variations in our experimental procedures. But this will become clearer as we proceed. "In the meantime, we believe that we have opened the door to an extraordinary ...Satellites map volcanic home of Africas endangered gorillas
...citing to get a look at some of the products we're going to be able to take into the field in future," rema...he go-no-go. "What is exciting is that now we are going further, basically entering into a production mode in order to elaborate all maps for all the select...$6 million appropriation to focus Sandia research on drinking water desalination, removal of arsenic
...on (ppb) to 10 ppb. "Many areas of the country are going from having no treatment of water to now having to do advanced treatment," Hinkebein says. "Small and large communities alike will have to adapt to the new standards." Albuquerque is one of the many communities affected by the new ruling. Arsenic con...Noah's modern ark: The role of ART in conserving endangered species
...chosen for them and refuse to oblige scientists by going through the motions. ART solves this problem neatly. One of Dr Wildt's successes has been the giant panda programme that he has been leading, which involves five Chinese breeding facilities, four North American zoos and more than 65 scientists, repr...Common chemicals morphing into potential toxins in Arctic
... far north. "It does appear to be an issue that's going to affect Arctic food webs and Arctic people who depend on them. We don't know toxicologically how much of these chemicals an animal can withstand before it might start to cause problems," says Martin, noting that previous studies have suggested that...Protein believed to control formation of memory identified by Scripps & UCSD scientists
... bundles known as chromosomes. But when a gene is going to be expressed, such as during the formation of long-term memory, the chromatin must be opened up and the DNA unwound from the histones. CBP plays a critical role in this process because it acetylates amino acids known as lysine on the histones, and......g the screen, a priori, you don't know what you're going to get," says Mullins. "Now we feel we have this little gold mine." Penn researchers Keith A. Mintzer, Greg Runke, and Anthony P. Wiemelt were also co-authors on the papers. This work was funded in part by the National Institutes of Health, the ...UK small firms pay lip service to green issues
...firm owners do not accept the government line that going green is good for business," says Andrea Revell, w...ut environmental issues. They did not believe that going green would be a particular draw for their customers. They were seldom asked if their ingredients we...Targeted therapy for lung cancer patients shows promise in extending lives
... cancer patients. "This is the most exciting thing going on in lung cancer today. For the next two decades, this will be the wave of the future in treatment." Patients with stage IV lung cancer who receive one course of chemotherapy have side effects of nausea, vomiting and can feel worn down. This two-pil...New national research effort needed to secure clean, adequate water supply in coming decades
... "Decision-makers at all levels of government are going to have to make difficult choices in the coming decades about how to allot limited water supplies, and they need sound science to back them up," Vaux added. Given the competition for water among farmers, environmental advocates, recreational users, ...AAAS 2004 salary survey: Despite long hours and low pay, life scientists love their work
...in the last three years, and fewer researchers are going through multiple postdoc positions while waiting for a job to open up. Heavier teaching loads, more nontenured faculty, delayed retirement and a need for more career advice are growing trends in the life sciences. ...Survival of the fastest: scientists 'selectively breed' winning Formula One cars
...you could evolve the car setup while the racing is going on. So if a car was damaged, at the next pit stop you could optimise the settings to offset whatever has gone wrong. You could even beam changes to the car while it is on the track, but somehow I don't think racing authorities would go for that." Det......ea level were to rise half a meter. Where are they going to go?" Science Editor-in-Chief Donald Kennedy a...ssly underestimating the amount of warming that is going to happen as a result of greenhouse gases." Scientists generally agree that temperatures are rising ...Whole body imaging allows better understanding of the immune system
...m," says Dr. Witte. "Over the coming years, we are going to see a greater and greater reliance on whole body molecular imaging techniques to evaluate any treatment, whether chemotherapy or antibody, in preclinical and clinical trials." ...