Sweet success in targeting sugar molecules to cells in living animals
... sugar molecules with chemically unique functional groups onto the surfaces of cells in living animals witho...cosylation is the addition of carbohydrate (sugar) groups to a molecule. It has long been known that the glycosylation patterns of sugar molecules on cell sur...Embryonic stem cell therapy shows steady benefits in rebuilding infarcted heart
... therapy, the cardiac contractile function of both groups was tested by echocardiography. Not only was the stem cell-treated group's left ventricular pumping significantly stronger than the sham-treated group, but the heart beat of the stem-cell group reacted favorably to "stress test," whereas the sham gro...When is a mouse like a test tube?
...ical system," Bertozzi said. "We design functional groups to be specific, so they don't react with the environment in the body. Ours is an elegant system, highly targeted and very selective." The reaction she focused on was a simple one between azides and phosphines, described last century by German synthet...Other highlights in the August 18 JNCI
...ay be able to help distinguish clinically relevant groups of neuroblastomas, according to the authors. Contact: Miguel Alaminos, Spanish National Cancer Centre, 34-95-822-8146 or 34-95-824-4034, malaminos@histolii.ugr.es Study Identifies Possible New Target for Anticancer Drug Development Expression of ...Rare mutations can significantly increase risk factor for heart disease
...the protein. They found these to be similar in the groups with high and low HDL levels. Additionally, they confirmed their results in an independent population of patients and examined cells from the individuals in that analysis to show that sequence variants in the low-HDL group were functionally importan...Hopkins scientists use blood proteins to detect ovarian cancer
... U.S. and international hospitals. Other research groups are evaluating ovarian cancer blood tests that use...completion of further validation studies in larger groups of patients. And even then, Chan notes, it is never going to be possible for a blood test to correc...Alcohol-use and depression among pregnant and postpartum women
...d 21 years later. For this particular study, five groups of prenatal variables (psychological standing, substance use, social factors, obstetrical complications, and demographics) were collected at four points in time (the 4th and 7th month of pregnancy, delivery, and 8 months postpartum) for 595 women. "W...Evolution of whale hearing unfolds in fossil record
...rch is based on cetacean fossils representing four groups of early whales. The earliest cetaceans, pakicetids (those that swam in ancient seas 50 million years ago), used the same sound transmission system as did land mammals, and so had poor underwater hearing. More recent cetaceans, remingtonocetids and...Joslin Diabetes Center launches research section on developmental and stem cell biology
...Cell Institute (HSCI). Funded by patient advocacy groups such as the Juvenile Diabetes Research Foundation (JDRF) and private foundations such as the Howard Hughes Medical Institute, HCSI was established in April 2004 in part to fill the funding gap caused by the Bush Administration's tight restrictions on...Newcastle scientists get UK's first stem cell license
...s. In early 2003 it became one of the first two groups in the UK to derive human ES (embryonic stem) cells from spare IVF embryos. Two members of the group, Professor Alison Murdoch of the Newcastle NHS Fertility Centerand Dr. Miodrag Stojkovic, a Reader in Stem Cell Biology and Embryology at Newcastle U...Despite darkness, nocturnal bees learn visual landmarks while foraging at night
... exploit food resources in relative peace. Several groups of bees and wasps--including the Central American halictid bee Megalopta genalis--have become nocturnal, and despite the darkness and their apparently insensitive compound eyes, they have retained remarkable visual abilities. In the new work, perform...Preschool bolsters early childhood immunity, reduces risk of young adult Hodgkin's lymphoma
...e of exposure to childhood infections is high when groups of children spend time in close proximity, as is the case in day care and nursery school settings," added Chang. "This frequent contact appears to prime the immune system toward a more mature type 1 response than is found among children of the same ...Why some animals have smaller eyes: Lifestyle matters
... on average. But breaking vertebrates into smaller groups -- such as birds, fishes, reptiles and mammals -- ...ts more complicated. And dividing all mammals into groups -- such as rodents and primates -- could make a scientist cross-eyed: Compared with all vertebrates,...Travelers' diarrhea not improved by restricted diet
...ave to avoid tasty cuisine. In a comparison of two groups of patients receiving antibiotics to treat travele...g, so University of Texas researchers compared two groups of 105 college students visiting Guadalajara, Mexico. The subjects in each group were receiving anti...UCSD researchers are first to demonstrate molecular link between inflammation and cancer
...is study, DSS and AOM were given to two additional groups of mice one group bred without IKK beta in the epithelial cells of the intestine; the second group without IKK beta in myeloid cells, which play an important role in the immune system by generating white blood cells called macrophages to induce infl...Early clinical treatment can halt progression of Alzheimer's disease, UCI researchers find
...,' phosphorylation being the addition of phosphate groups to particular amino acids in a protein. Once the tangles become hyperphosphorylated, they are unaffected by the antibody treatment for the plaques, probably because they've become more resistant to the cellular degradation machinery. This means that ...NHGRI adds 18 organisms to sequencing pipeline
...time on the basis of proposals from individuals or groups of scientists, the National Advisory Council for H... approved a comprehensive plan that identified two groups of organisms on the basis of their collective scientific merits. "Science tells us that the mos...Dispute over life in Antarctic lake
... refrozen lake water, known as accretion ice. Four groups of researchers have found organisms in samples of this ice, suggesting that the lake supports a small but thriving microbial ecosystem. But molecular biologist Sergey Bulat of the Petersburg Nuclear Physics Institute, Russia, has created a furore by ...Outcome for acute lymphoblastic leukemia linked to gene expression patterns
... The researchers identified four groups of genes, each of which had a characteristic patte...t. Jude patient populations, even though these two groups of children were treated with these drugs in different countries and on different protocols," said R...Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
...t promising vaccine candidate, was tested in three groups of ten mice each. One group received the purified protein alone; a second group received the protein plus an adjuvant called Alhydrogel; and a third group served as the control, receiving an injection of saline solution instead of the vaccine. ...