Joslin researchers clarify mechanisms for beta-cell formation
...es in San Diego, Calif., studied this compensatory growth in two different genetically engineered animal mod...ot derived from duct cells. Rather, the beta-cell growth in insulin-resistant states occurs by "epithelial-to-mesenchymal transition," a mechanism in which c...JCI table of contents September 15, 2004
...22930.pdf No Compensation Without PDX-1 Extra growth of pancreatic b cells can reduce the effects of in... liver-specific insulin receptor knockouts, b cell growth was severely limited. Further analyses provided evidence that the hyperplasia loss was due to a redu...New fruitfly model of diabetes has future implications for pancreatic cell transplantation
... energy status of an animal can adjust an animal's growth and metabolic state," he says. "Now we have a model for that." Coaxing stem cells to become pancreatic islet cells for transplantation is potentially a permanent treatment for diabetes. As a developmental biologist, Rulifson is now concentrating...IBD (Crohn's, Colitis) 'joins' cancer, inflammatory diseases in associated blood vessel growth
...st the last decade it has been recognized that the growth of new blood vessels is critical in the pathogenesis of cancer because it increases blood supply to malignant tissue. Relatively recently, a novel pathogenic role of angiogenesis has been established for such chronic inflammatory diseases as rheumato...Tufts University establishes $4 million dollar tissue engineering resource center
... "This Center will help stimulate new economic growth by filling an important niche for start-up companies looking for support as they move their technologies to the next level," said Jamshed Bharucha, Tufts provost and senior vice president. "Tufts is proud to be part of this growing field," he added. ...Molecule awakens and maintains neural connections
...e discovered a critical protein that regulates the growth and activation of neural connections in the brain....w the brain to create memories. In exploring the growth and development of dendritic spines, Shi, the Jans, and their colleagues first identified a gene in ...Researchers identify distinctive signature for metastatic prostate cancer
...er protein in the pathway, Smoothened, inhibited growth of these cell lines. Furthermore, they showed that when the tumor cells were introduced into mice, cyclopamine caused a permanent regression of the tumors. "We interpreted the finding in mice to mean that we had probably killed tumor stem cells resp...Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
...equently experience problems with poor and delayed growth and intestinal bleeding. This in part is due to impaired actions of growth hormone, a naturally occurring compound that normally acts to promote both growth and healing. About...Researchers discover why mutant gene causes colon cancer
...knew what the APC gene did that it regulated cell growth and division but now we know we've been missing a...thus control the undifferentiated and uncontrolled growth of colon cells that results in colon cancer." Several years ago, University of Utah researchers...Breaking new ground in germ cell guidance
...ction of LPPs in developmental processes from axon growth and patterning to extraembryonic vasculogenesis....New research shows air pollution can reduce children's lung function
... also suspect that air pollutants might dampen the growth of alveoli, tiny air sacs in the lungs. The research team will continue to follow the study participants into their early 20s, when their lungs will be fully mature. They want to find out whether the participants will experience respiratory symptoms,...Sandia experiments may reduce possibility of future water wars
...monitor the plant's water status, temperature, and growth rate. "We envision these [futuristic] sensors linked together [via wireless communications], possibly on every plant, so the plant tells the control system directly what it needs, instead of merely monitoring air around the plant. The...Maine-based biophysics institute gets funding for first US-based 4Pi nanoscale microscope
...cates that controlling the migration of fibroblast growth factor can prevent reocclusion of coronary arteries after angioplasty. We are confident that this fruitful collaboration with the physicists in the IMB will reveal many as yet unsuspected discoveries of value to the medical community." The National S...A new protein is discovered to play a key role in cancer progression
...tivating TGF-b signaling necessary to suppress the growth of cancer cells. When cPML is lost, TGF-b signalin...rom Pml-null mice are resistant to TGF-b dependent growth arrest, induction of aging (cellular senescence), and cell death (apoptosis). However, when PML func...Extreme stretch-growth of axons
...the Journal of Neuroscience. "This type of stretch growth of axons is really a new perspective," says Smith. Despite the extreme growth in length, the axons substantially increased in diameter as well. Using electron microscopy, they co...Single isolated mouse skin cell can generate into variety of epidermal tissues
...r experimentation led to the identification of two growth factors, known as Bmp6 and FGF18, which are expres... a holding pattern -- an environment that inhibits growth -- and that is why they have been recognized as slow cycling," says Lowry. After expanding an isolat...Genuine stem cells found in skin might treat hair loss, wounds
...ecular properties. While both cell types exhibited growth inhibition within their niche, the two underwent stem cell self-renewal in laboratory dishes, a quality that could prove clinically useful if it holds for stem cells derived from haired human skin, said Fuchs. Furthermore, clonal analyses revealed th......s of avian beaks are determined by areas of active growth amidst areas of slow growth in a developing embryo, and are associated with activity levels of a specific protein called bone mo...Battle between bubbles might have started evolution
...d a cytoskeleton that influenced stability, shape, growth or division, he said. However, Szostak and his co...proposed that the genetic material could drive the growth of cells just by virtue of being there," he said. "As the RNA exerts an osmotic pressure on the insi......HB could enter, and, more importantly, inhibit the growth of those cells. "When we saw that we could activate cell death in a specific way in whole cells, we were eager to conduct animal studies," said Walensky. So, the researchers tested the effects of SAHB on mice that harbored human leukemia cells. "We ...