NRH1 and Wnt signaling come together in convergent extension
...phins are molecules that function in the survival, growth and migration of neurons.) However, on testing its affinity for neurotrophin ligands, the group found that, unlike p75NTR, NRH1 did not bind with neurotrophins, which led them to seek other biological roles for the protein. Experiments in which NRH1 ...Drug prevents chemotherapy-induced hearing loss, study finds
... is administered intravenously to slow or stop the growth of cancer cells. In addition to head and neck cancers, the drug is used to treat cervical carcinoma, lung cancer, neurologic cancers and a wide variety of other malignancies. But it injures hair cells of the cochlea, the spiral, inner-ear structure c...Sponge substance works well with yew derivative to thwart cancer cell proliferation
...ee derivative Taxol (paclitaxel) in preventing the growth of cancer cells, according to research published i...odermolide or paclitaxel prevented the cancer cell growth by only 9.6 or 16 percent, respectively. The drugs also combined to induce programmed cell death, or...Impact of Earth's rising atmospheric carbon dioxide found in world oceans
...rs that as seawater CO 2 levels rise the skeletal growth rates of calcareous plankton will be reduced as a result of the effects of CO 2 on calcification," said Victoria Fabry, a biologist at California State University at San Marcos and a paper co-author. Recent studies have shown that calcification rat...Patients' cells from tumors, the immune system merged for customized cancer therapy
...s that cancer patients can tap to help fight tumor growth and metastasis may well be their own immune system...tients, and stabilization and containment of tumor growth in late stage breast and kidney patients through application of customized vaccinations made from th...Carnivore extinction risk determined more by biology than human population density, says study
...es that live in regions of rapid human population growth and have a biology predisposing them to decline," they write. They highlight in particular the threat to African viverrids, or civets and genets, even though they are currently considered relatively safe. The authors, from Imperial College London, Un......AC133-positive stem cells from normal blood. After growth in culture, these cells were subsequently injected into the skeletal muscle tissue of mice that are a model for human Duchene muscular dystrophy. The human stem cells invaded the damaged muscle fibers, expressed muscle fiber markers, and formed funct...Scientists identify molecular link driving spread of skin cancer
...umor that was smaller in size and lacking in ample growth of novel blood vessels, compared to the tumors that developed in mice that received no synthetic peptide treatment. By identifying the peptide that inhibits the laminin α5CD44 interaction from propelling cancer cell migration, invasion and ang...JCI Table of Contents, 15 July 2004
...AC133-positive stem cells from normal blood. After growth in culture, these cells were subsequently injected...ation of the molecular basis of Marfan syndrome: a growth industry AUTHOR CONTACT: Peter H. Byers University of Washington, Seattle, WA 98195, USA. Phone: ...Genetic model for devastating form of paraplegia suggests new treatments
...nents to distant regions of the cell, regulate the growth of cellular branches and provide a substrate for important protein interactions. All of these functions are critically dependent on dynamic changes in microtubule stability. Researchers in the laboratories of Kendal Broadie at Vanderbilt University a...'Anti-plume' found off Pacific Coast
...ard through the Earth may be enough to trigger the growth of bacteria at startling depths. Last year, in an unrelated study, OSU oceanographer Martin Fisk and a team of researchers found bacteria in a hole drilled 4,000 feet through volcanic rock. Basalt rocks have all of the elements required for life, Fis...Italian research links diet with endometriosis risk
...ough it were still inside the uterus. The repeated growth and disintegration of endometrial tissue in the abdomen can cause bleeding, pain, inflammation, adhesions and infertility. It is estimated to affect up to five in every 100 women in Italy and probably in the rest of Europe. The researchers used inte...Gene profiles could improve acute leukemia diagnosis and lead to better treatments
...tic mutation that contributed to the formation and growth of the leukemic cells; and it corresponded to over- or under-expression of sets of genes from leukemic cells as compared to their expression in normal white blood cells. Prognostic subtypes are categories of different forms of AML that are recognized...Growth study of wild chimpanzees challenges assumptions about early humans
SANTA CRUZ, CA--A new study of wild chimpanzee growth rates, published in the Early Edition of the Proce...rk other life events, such as completion of brain growth (90 to 95 percent of brain growth is complete when the first permanent molar erupts) and life-histor...A genetic model for hereditary spastic paraplegia (HSP) disease
...nts to distant regions of the cell, regulating the growth of neuronal branches, and providing a substrate for important protein interactions. Microtubules grow and shrink, and their stability at a given time and place can be regulated by other proteins to facilitate specific cellular functions. The new res...New research suggests previously unrecognized mechanism by which blood vessels are patterned
...rrupted in mice, results in CHD and defects in the growth and arrangement of blood vessels (patterning). "W...This research could lead to new ways to modify the growth of blood vessels because this receptor seems to tell blood vessels in which direction they should gr...Secret behind hard exoskeletons, spreading wings revealed
...a specific, unique configuration. Proteins such as growth factors have the cystine knot configuration. "The exciting thing is that this is the first cystine knot protein with a function that has been found in insects," Honegger said. "What you can gather from that is that nature is really very conservative....$1.86 billion boost for UK science and innovation
...GDP over the next decade, and provides annual real growth in public science funding of 5.8 per cent over the...ld class and financially robust research base with growth in public and private investment. The framework has been developed with stakeholders in the research...Sequential signals choreograph embryonic tubule formation
...research study demonstrates that a single chemical growth factor orchestrates a complex developmental proces...g development, chemical signals such as hepatocyte growth factor (HGF) cause individual cells to migrate to different locations, increase in number and differ......nucleus. When cells were stimulated with a common growth factor, hSef interacted with activated ERK in the cytoplasm. The inhibitor was only switched on when the Ras/ERK MAP kinase pathway was activated. Interestingly, activated hSef works not by directly inhibiting the activity of ERK, but by preventing ...