Researchers Find Possible New Route to Making Cancer Cells Vulnerable
... correctly.In other words, the two drugs primarily halt the cellular pump by removinga vital part, like a valve from a car's fuel pump. "Cyclosporin-related drugs are now being tested for their ability toreverse chemotherapy resistance in cancer patients, but little had beenknown about how these common i...Antarctic Science Season Gears Up With Searches for Meteorites, Neutrinos, and New Life Forms
...se gasses in the atmosphere. The drillers plan to halt at approximately 3650 meters depth, stopping above Lake Vostok, the subglacial lake beneath Vostok Station that is comparable in size to Lake Ontario. The lake and any life it may harbor have apparently been sealed off from the atmosphere for hundre...Stopping "Cellular Suicide" Could Boost Production In Biotech Labs
...cial organs made from animal tissue. The key is to halt apoptosis, which is often triggered by changesin acell's environment. "It may be a viral infection, the loss of akey nutrient,radiation or a chemical toxin--all at sub-lethal levels,"Betenbaugh explains."These would not kill the cell by themselves. N...Jefferson Scientists Discover Mechanism Of Viral Link To Disease Commonly Associated With Asbestos
... pRb-2/p130 gene and demonstrate that it could halt the growth of tumors. He has been studying the family of tumor-suppressor genes for nine years. "The findings of Dr. Giordano's team will point the way to future developments in gene therapy," said Dr. Emanuel Rubin, M.D., chairman...Newly Discovered Human Protein Provides Important Target For Cancer Therapy
...ys. "Blocking hEST2 expressionor activity could halt or slow the progression of malignant tumors." In fact, say Meyerson and Counter, the foundation for an anti-telomerasedrug may already exist. The three known catalytic subunits of telomerase (fromhumans, yeast, and a protozoan, respectively)...Smoking Mice Lead To Emphysema Breakthrough
...is enzymeor related enzymes might give us a way to halt the disease." Emphysema, almost always caused by smoking, robs lungs of theirelasticity and leaves patients gasping for air. The lungs actually becomeoverinflated, leaving no room for deep breaths. About 2 million Americans sufferfrom the dis...Pitt Researchers Construct Novel Delivery System For Gene Therapy Of Liver Disorders
...troducing a good copy into targetcells may slow or halt the development of these disorders. Genes can be delivered to cells by a variety of "cars" or deliverymechanisms. Some of these delivery systems only can access cells that areactively dividing and thus are prevented from entering non-dividi...DNA Enzyme Works In Crystal Form; Yields New Insights Into Gene Copying
...ces jammed into a puzzle -- and contorts itself to halt the DNA copyingprocess to allow corrections. ...tions confirmed how the enzyme changes its shapeto halt production. The Duke biochemists also have launched experiments in which theyintroduce canc......e inmitosis, the APC seems to be a perfect site to halt cell division. Like theanticancer drug Taxol that also disrupts mitosis, the advantage with an APCinhibitor would be preferential delivery to rapidly dividing tumor cells. "A lotof normal cells are just not dividing at all," says Yu. These law-abidin...USC Study On Soy's Anti-Cancer Effects
...n test tube studies, the compound has been shownto halt cell growth and angiogenesis (the development of new blood vessels thattumors require for continued growth.) Another team gave genistein to female ratsas newborns and later exposed the rats to a tumor-inducing carcinogen. Thetreated rats developed ma...UNC-CH Researchers Discover Key Cancer Control Mechanism
...to cancer,normally low levels of P53 skyrocket and halt cell proliferation similar to howa fire extinguisher smothers a blaze, Xiong said. Healthy cells keep P53 incheck when it is not needed by degrading it with the MDM2 protein. "When DNA is damaged, MDM2 must be decreased to all...First Evidence That Localized Arthritis Gene Therapy Heals Distant Diseased Joints
...to block the action of these proteins to reduce or halt the disease process. In their study, the Pitt investigators provoked rheumatoid-likearthritis in rabbit knee joints by injecting them with a protein that causesinflammation and joint erosion. The investigators used an adenovirus (a vir...Study 'Gone With The Wind' Provides Stellar Ecological Example
...se the size of Great Exuma issubstantial enough to halt the impetus of a storm surge. The effect is thatwith the whole ocean at a higher level for several hours, everything that wasn'tstripped away when the surge hit the island was drowned or carried off bywater." Losos said there are several uni...The Best Molecular Snapshot Yet Of Cells Affected By Alzheimer's Disease
...to detect thedisease before there are symptoms and halt the progression.That's the ultimate dream." He believes the technology can alsobe used to study molecular differences between healthy and sickcells in many other diseases, including heart disease, muscledisorders, and strokes....Ribozymes To The Rescue: New UF Gene Therapy Shows Promise For Treatment Of Inherited Blindness
...l sight can be lost. Currently, there is no way to halt the deterioration. Since the UF research was published in the August issue of Nature Medicine, Lewin has heard from many other scientists who are working to apply "ribozyme rescue" to heart disease, neurological disorders and viral diseases. "UF's ...UCSF Researchers Pinpoint Molecule That Triggers Deadly Progress Of Pulmonary Fibrosis
... then a drug thatblocks the integrin locally could halt the deadly lung scarring of pulmonaryfibrosis. Currently in the U.S., the condition traps more than a hundredthousand people in the grip of gradual suffocation. "Knowing the role of the integrin, we have a potential target to control TGFBeta activity...Story Tips: Engineering Students Pursue Cutting-Edge Research
... the body to produce more nervegrowth factor could halt and possibly reverse the brain damage caused byAlzheimer's, the scientists believe. The team has studied a Vitamin D compound that appeared to increase theproduction of nervegrowth factor in the brain, but was toxic to the rest of the body. Zand test...Key Peptides Found That Stop -- Even Reverse -- Kidney Disease In Lupus
...ied key peptides -- small bits of proteins -- that halt kidney disease inlupus, an autoimmune disease that attacks the body's own DNA. In an article in the May 15 issue of the Journal of Immunology, SyamalDatta, M.D., the Solovy Arthritis Research Society Professor, and colleagues atNorthwestern...Jefferson scientists detail mechanisms of programmed cell death
... caspase might thenblock the apoptotic pathway and halt the process from occurring." The next step is to develop such drugs, he says, which may involve"developing peptides, substances that mimic the chemical 'recognition sequence'on the two crystal structures of caspase-9 or Apaf-1 and see if they...New study finds link between decline in the city's TB rates and intensified control programs
...odetermine the effect of interventions designed to halt tuberculosis. Covering1991-97, the study examined the rate of TB cases overall within the City andCounty of San Francisco as well as rates within high-risk groups, such aspersons infected with HIV. "We found that the intensified TB control measure...