Tag: "halts" at biology news

New drug shows promise against Gleevec resistance in mice

...d implementation of Gleevec, a drug that virtually halts the progress of chronic myeloid leukemia. Yet for some patients who harbor particularly stubborn genetic mutations, Gleevec fails miserably. Now, Howard Hughes Medical Institute (HHMI) researchers at the University of California, Los Angeles, ...

RNAi delivery system crosses blood-brain barrier to target brain cancer

... a forwarding delivery address, and a message that halts proliferation of the tumor cells. Liposomes are the parcel. Composed of lipid, or fat, molecules that align to form an enclosed membrane much like a sealed envelope, the liposomes are constructed with thousands of molecular probes that recognize two...

New screening method turns up potential compound for treating anthrax

...Chicago scientists have identified a compound that halts the activity of a deadly toxin called anthrax lethal factor in laboratory tests. Nature Biotechnology will publish the findings online on May 16 and in the June issue of the journal's print edition. Anthrax lethal factor can only be effectively t...

Kinase backgrounder: Iressa discovery part of major kinase project at Dana-Farber

...at are stimulating the cancer. In some cases, this halts or shrinks the tumor....

Cellular problems found behind complex obesity syndrome

...tly, the highway system falls apart, cell division halts and the cell dies. "But our experiments also revealed something really interesting about pleiotropy -- genetic diseases that severely impact only a smattering of tissues," says Nicholas Katsanis, Ph.D., head of the team's contingent from the ...

JCI table of contents, March 1 2004

...logic and gene expression data show that a vaccine halts HER-2/neu preneoplastic lesions AUTHOR CONTACT: Federica Cavallo University of Turin, Orbassano, Italy. Phone: 39 11-670-8119 Fax: 39-11-236-8117 E-mail: federica.cavallo@unito.it View the PDF of this article at: https://www.the-jci.org/press/1985...

Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs

...to repair the mismatch. If this fails, the system halts the cell's replication cycle and causes the new cell to die--literally, to pop out of its skin in a process called apoptosis. In addition to helping cells circumvent DNA damage that might otherwise lead to cancer, the mismatch-repair system also pla...

Breast cancer can be reversed in laboratory mice, scientists report

...ncer-prone mice from developing breast tumors, and halts further tumor growth in mice that have already developed breast cancer. "This study shows that it is absolutely essential to have the beta-1 integrin gene present in order for mammary gland tumors to develop. We now have a good target for biological ...

Close interaction seen between blood vessel development and fat tissue formation

... interwoven that interfering with one process also halts the other. These findings from researchers at Massachusetts General Hospital (MGH) could eventually help to solve problems ranging from cancer, to obesity, to the development of replacement organs. The study, which will be printed in the Oct. 31 is...

Molecule identified that contributes to essential cell functioning process

...s School of Medicine. "We think this novel enzyme halts the synthesis of histones when they're no longer needed by rapidly degrading histone mRNAs. This is important because too much histone synthesis can be lethal to the cell." Marzluff's focus on histone mRNA stems largely from his team's 1996 discover...

Mathematical prediction of on-off switches in cell division proven

...tosis), we eliminated the checkpoint that normally halts the cell cycle if there is something wrong with the DNA." Co-authors of the PNAS article are Wei Sha, who completed her master's degree with Sible and is now a Ph.D. student at the Virginia Bioinformatics Institute at Virginia Tech; Jonathan Moore of...

Peptide suppresses multiple sclerosis-like disease

...in effect kills the T cell and halts expansion of active disease. "Increasing the number of specific white blood cells is one of the major goals of the immune system. Once T cells are exposed to their specific antigen, that ex...

NYU biologists develop better way to 'silence' neurons

...negative potential, which silences the neurons and halts their flow of electrochemical information. Surprisingly, this resulted also in a complete deactivation of the organisms free-running molecular clock that ordinarily cycles with a 24-hour rhythm. Free-running refers to challenging the clock with con...

Researchers develop first oral drug to treat smallpox infection

March 20, 2002 An oral drug that halts the deadly action of smallpox and related orthopox viruses in lab tissue culture cells and in cowpox-infected mice has been developed by researchers at the Veterans Affairs San Diego Healthcare System (VASDHS) and the University of California, San Di...

Herb used to treat migraine headaches could be used to develop new anti-inflammatory drugs

...verfew targets a protein called IkappaB Kinase and halts that proteins role in the inflammation process. "The results pave the way for the development of novel anti-inflammatory drugs for a variety of illnesses and symptoms, such as headache, swelling, redness and inflammation," said Craig Crews, associate...

Scientists unlock molecular mechanism that controls cell growth

... to high levels. The researchers showed that Hsp70 halts cell growth by binding to the protein Bag1. In a healthy environment, Hsp70 keeps out of the way, allowing Bag1 to bind to a different protein, Raf-1, which sets the cell growth signalling process in motion. But when Bag1 is bound to Hsp70 during str...

Common algae can be valuable source of hydrogen fuel

...he absence of sulfur stops photosynthesis and thus halts the cell's internal production of oxygen. Without oxygen from any source, the anaerobic cells are not able to burn stored fuel in the usual way, through metabolic respiration. In order to survive, they are forced to activate the alternative metabolic...

Scientists dissect bacterial crosstalk

... studied FucR mutants.She deduced that the protein halts the transcription of the five genes byinteracting with the common regulatory region. But when fucose is available, itno longer can bind to that spot on the DNA. So the bacterium can make theenzymes that metabolize fucose. Bacteria frequently employ t...

Images of enzyme suggest way to improve DNA sequencing

...en it incorporatesthat compound, like a train that halts on the track when it hits a rock.Therefore, the length of a new DNA chain indicates where that particularnucleotide occurred. After the copies are separated by size and reacted withfluorescent chemicals, DNA sequencing machines can determine which nu...

UCSF Scientists Report On A Transcription Factor That Could Stimulate Heart Cells To Repair Damage Caused By Heart Attacks Or Birth Defects

...al point in the cycle when cell duplication either halts orcontinues, knowledge about its actions could uncover potential new targets fordrugs to stop the uncontrolled cell division in cancer. Using recombinant DNA techniques, Bernstein cloned hCdc5 in 1997 and showed thatit is a novel human protein involv...

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