Scientist who discovered Sly syndrome finds new research path to explore for treating the disease
...rs Medical Center in St. Louis. "Now we have a new haystack to look in. Instead of learning how to build a truck to deliver the enzyme across the blood-brain barrier, we need to figure out how to get the stop light to switch back to green. In other words, how do we get the blood-brain barrier's truck to start...Genetic mutation found that is major contributor to type 1 diabetes
...me process they liken to looking for a needle in a haystack which narrows the search by predicting which of some 40,000 genes might be involved in a disease based on what scientists already know about the disease and the genes. "You guess the function, you guess the disease possibilities, then you guess whic...Genome-wide screen reveals new tricks of old genes
...igure out what new knowledge may be lurking in the haystack is very difficult," says Forrest Spencer, Ph.D., associate professor in Hopkins' McKusick-Nathans Institute of Genetic Medicine. "But by overlapping information from two screens, we were able to figure out what Mother Nature was trying to tell us tha...... and DRAGON, can be used to find the needle in the haystack of microarray data. As an example, Pevsner applied the programs to microarray data from Down syndrome. "In some conditions, like autism, the biological cause is still unclear, but even in Down syndrome, which we know is the result of having an ...Genetic clues for finding and treating cardiovascular disease (CVD)
...t of looking for a needle in a haystack. The human haystack is comprised of 3 billion base-pairs, the equivalent of the number of seconds in 95 years. Between 30,000-100,000 human needles or genes need to be found inside the stack, and simply finding them is not enough. Junk DNA genes must be set aside and s...Stool test for colon cancer reported by Kimmel Cancer Center at Johns Hopkins
...is like searching for the proverbial needle in the haystack when you don't even know the size or shape of the ...kes it possible to find the needle by dividing the haystack into very small, more manageable piles, " Traverso explains. They used Dig-PT to analyze all of the ...New test detects colon cancer gene
...into many smaller samples -- like separating a big haystack into tiny haystacks, that made it much more likely that we would detect the 'needles,' or APC mutations." The scientists also relied on the knowledge that all mutations stop protein production by the APC gene, resulting in truncated proteins that...Hidden toxin gene in chlamydia linked to chronic illnesses
...aystack. The genome gave them a good idea of what haystack the needle was in, where it was located, and what the needle might look like. Anthony S. Fauci, M.D., director of NIAID, agrees that genome sequencing offers great promise in improving global health. "Determining the DNA sequence of the world's lead...DNA gene chips and novel software used to describe kidney development
..."The thousands of housekeeping genes represent the haystack in which the needles - or genes that turn on or of..."Our goal was to whittle away all the chaff in the haystack by placing each gene expression measurement in the context of all the others." First, the investigat...Spider Venom Stops Stroke Brain Damage
...chemical, Meinwald said, "Looking fora needle in a haystack is easier. There you just get a big magnet and you'llfind it. Looking for this chemical, we didn't know what we'd find. We didn'tknow what kind of structure we were looking for." HF-7 works in the brain by blocking one in a family of receptor mol...... protein coding portion of the RP2 gene) in a haystack of 4,000,000 base pairs of X-chromosomal DNA where, according to data from family studies, the RP2 gene must be located. In order to get a hint where to look first, the researchers applied the relatively new yeast artificial chromosome ...