Tag: "helicase" at biology news
Bacterial Protein Structure Hints At Mechanism Of A Class Of Premature Aging Diseases
... to divide into two," White said. Recently, helicase
malfunction has been found responsible for a class... block to replication, actually interacts with the helicase
protein. "That's a major controversy in this field," White said. Acompeting theory, published...
Vertex Pharmaceuticals Researchers Report Three-Dimensional Structure Of Hepatitis C Helicase Enzyme; Report In Structure
...e. The publication follows the presentation of the helicase
structure atthe Second International Conference on...ng the structural information to designhepatitis C helicase
inhibitors as new antiviral drugs to treat hepatitis Cvirus (HCV) infection. "This paper presents ...
Scientists Show Proteins Function Individually As Part Of DNA Repair
...ong scientists by showing that a proteincalled DNA helicase
II can act individually and need not be coupled wi... work." A gene known as uvrD produces DNA helicase
II. Matson's laboratorycurrently is working on a yeast DNA helicase
similar to the helicase
Peering at a machine that pries DNA apart
... way by bindingproteins on the DNA's back. Yet the helicase
knocked these off as it forced itsway through. Se...do all sorts of things. The ring-shaped, hexameric helicase
studied herespearheads a complex of enzymes as it pries apart the DNA strands forreplication. Other ...
Researchers discover new risk factor for colon cancer
...perhaps there is a reduction in the ability of the helicase
to maintain or repair DNA that accompanies its reduction in amount." The results of the mouse study spurred an investigation of the role of BLM in colon cancer incidence among Ashkenazi Jews, an ethnic group in which one percent of the population ca...
DNA unzipping found to take at least two proteins, not one alone
... "Our study shows that that is not true. A single helicase
can move along the single-strand tail of a DNA, bu...ed energy transfer efficiency from each DNA during helicase
binding and movement. Red or green fluorescence signals appeared and disappeared, indicating distan...
Scientists identify genetic link between cancer and aging
... of human chromosome 8. The WRN gene encodes a DNA helicase
(an enzyme that unwinds DNA) involved in DNA replication and repair. As published in the July 1 issue of Genes & Development, Dr. Carla Grandori and colleagues have discovered that WRN expression is regulated by the MYC oncoprotein, which is implica...
DNA throttle controls molecular machine
...C Davis. By controlling the activity of the RecBCD helicase
enzyme, the "Chi" sequence can affect how efficiently genes are repaired. RecBCD unwinds the DNA double helix so that the genetic code can be read, copied or repaired. This unwinding is an essential first step in most processes involving DNA. The res...
St. Jude researchers create image of enzyme that orchestrates natural genetic engineering
...some as a blueprint. The scientists studied the T4 helicase
because it is a simple but effective model for understanding how similar helicases perform the same job in human cells. The finding is important because UvsW is vital to the processes of DNA replication and repair, keeping the genetic material "stabl...
Something old, something new
...gous recombination, exons 10, 11 and 12 containing helicase
domains II, III and IV were deleted," states Dr. Arceci. These PASG-mutant mice displayed numerous abnormalities, including developmental growth retardation and characteristics associated with premature aging, including graying and loss of hair, redu...
Findings redefine mechanism of action of RNA helicase enzymes
... Wherever RNA occurs in the cell, ubiquitous RNA helicase
enzymes are responsible for rearrangements of such complexes. RNA helicases are proteins that burn the universal cellular fuel molecule ATP and use the energy gained from this reaction to unwind double-stranded RNA. It has long been assumed that th...
A better way to copy DNA
...mics nature's method of replicating DNA by using a helicase
enzyme to denature the DNA. As a result, the entire HDA reaction can be performed at one temperature that is optimized for synthesis, eliminating the need for an expensive and power-hungry thermocycler. HDA could expand the application of DNA amplifi...
Yale scientists visualize details of how hepatitis C unwinds RNA
...lished in the journal Nature focuses on an enzyme, helicase
NS3, that unwinds the RNA virus for replication in...ajor drug target against HCV and understanding the helicase
function will aid in the development of HCV inhibitors. Pyle's results contradict the idea that heli...