Tag: "helix" at biology news
Wiley publishes Welcome to the Genome: A User's Guide to the Genetic Past, Present, and Future
...t in length. The information stored in its double helix
structure could fill 142 Manhattan phone books. The study of genomics has already impacted so many areas of our lives, from the promises of gene therapy and personalized medicine to international trade disputes over genetically modified foods, to th...
Optimizing protein's 'death domain' halts leukemia in laboratory study
...roved successful, it would show that the BH3 alpha helix
and alpha helices from many other proteins could...ensky's goal was to return the isolated amino acid helix
to its original shape after its removal from the BH3-containing protein. Drawing on his dual backgro...
Rutgers chemist uses NMR to elucidate protein-DNA interaction
...oteins slide along the lengthy strands forming the helix
structure of DNA until they reach their intended d...t forms chromosomes. Structurally, DNA is a double helix
made up of two strands of genetic material spiraled around each other. Each strand contains a sequen...
Proteins transform DNA into 'molecular velcro'
...or cell division actually interact with the double helix
to fashion it into a kind of "molecular Velcro," researchers have discovered. The proteins, called condensins, are important for a variety of housekeeping processes in chromosomes, but the mechanics behind their function have been largely un...
Shortened chromosomes linked to early stages of cancer development
...that separates the strands within the DNA's double helix
structure. The Hopkins scientists then added a fluorescent probe specific for telomere regions. As the DNA re-forms into a double helix, it blends with the fluorescent molecules, enabling scientists to examine specific chromosomal locations under a...
Rewriting textbooks on DNA crossover
... occur. They found that Mer3 unwinds theDNA double helix
but works only in one direction relative to thebroken DNA end. It blocks extension of the DNA strand in the oppositedirection. Mer3 therefore helps to stabilize the Holliday junctionstructure and promotes crossover recombination, Hunter said. ...
Molecular midwives hold clues to the origin of life
...eat frequency, as they do in the well-known double helix
of DNA. But if, Hud and company propose, a molecular midwife such as proflavin were present, it would create a platform on which two bases could stack and pair with each other. As pairs of nucleotide bases stack with interspersed midwives, in a Dagwo...
Visualizing the central dogma
...58, five years after he helped discover the double helix
structure of DNA, Francis Crick coined the term "Central Dogma" to characterize the all-important cellular processes whereby DNA is "transcribed" into RNA and RNA is "translated" into protein. Since then, researchers have typically examined individua...
USC researchers link unusual DNA structure to cancer
...int areas of DNA that are not arranged in a double helix
and to explore them." There's plenty of work left to be done before the fragile site is fully understood, notes Sathees Chukkurumbal Raghavan, Ph.D., a research associate in the Lieber laboratory and the paper's first author. "While we know it deviat...
Exposure to low-level magnetic fields causes DNA damage in rat brain cells, researchers find
.... A break on one side of DNA's ladder-like double helix
is relatively easy to fix. Repairs are much harder if both sides of the helix
are broken, and, as a result, the probability of a mutation is substantially higher. Lai and Singh f...
Mind Science Foundation announces Rare Consciousness Research Awards
... Prize-winning biologist who identified the double helix
DNA. Other Award recipients announced today by the Mind Science Foundation are: Abraham Verghese, M.D., MFA, D.Sc. (Hon.), Director of the Center for Medical Humanities and Ethics at the University of Texas Health Science Center and author of tw...
Nanotech instruments allow first direct observations of RNA 'proofreading'
...s to make precise genetic copies from a DNA double helix
that consists of billions of chemical bases known ...n RNAP adds the wrong base, it backs up on the DNA helix
a little bit, cleaves off the piece of RNA that has the bad base in it and starts up again. That's t...
Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
...its DNA. Ideally, the two strands of DNA's double helix
fit together like a zipper. If a duplicated pair of DNA bases forms a mismatch that cannot bond properly, the mismatch-repair system attempts to repair the mismatch. If this fails, the system halts the cell's replication cycle and causes the new ce...
Researchers create 'supersized' molecule of DNA
... created an expanded molecule of DNA with a double helix
wider than any found in nature. Besides being more...bases DNA typically comes in the form of a double helix
- two parallel strands of genetic information coiled together like a long, twisted ladder. Each rung...
Battle of the DNA bulge may help thwart cancer
...g copied, a protein untwists and unzips the double helix
that joins the base pairs. Another protein then co...hat the bulge could sit there on the inside of the helix
with nobody across from it, or it could flip outward and point into the solution," Pettitt says. The...
DNA throttle controls molecular machine
... genes are repaired. RecBCD unwinds the DNA double helix
so that the genetic code can be read, copied or repaired. This unwinding is an essential first step in most processes involving DNA. The research findings, which are published in the September 5 issue of the journal Cell, could explain how short DNA ...
MicroRNAs - Tiny molecules shape up plants
... also available in German . Since the DNA double helix
was discovered 50 years ago, biologists have focused on the role of DNA in controlling gene activity. Only recently have scientists begun to appreciate the importance of microRNAs in keeping gene activity in check, a discovery that was hailed as the ...
'Unzipping' double helix to study protein-DNA interaction
...Watson and Crick described the structure of double helix
DNA, Cornell University biophysicists are discover...they learn which is which. Better yet, the double helix
rezips as soon as tension is relaxed so that the same bit of DNA can be recycled again and again wit...
A two-lane road to ruin
...A nucleus by cutting the strands of the DNA double helix
at numerous sites. The research team of the Max-Planck-Society in Martinsried now explains how the two identical molecules are assembled into a doubled-headed protease for the defense. The two catalytic centers point in exactly opposite directions (s...
Study finds direction of enzymes affects DNA repair
...DNA up - to correct our heredity molecule, the DNA helix
that is within each living cell." The explosion of...ells, repair enzymes travel up and down the double helix
strands of DNA until they find a damaged area. The enzymes cut out the lesion and fill the gap with ...
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