Another transmembrane protein structure solved by Rockefeller scientists
...ices around to put the partial positive end of the helix near the chloride ion. Its very beautiful." The gating mechanism of the chloride channel also is unique. The crystallographic images from MacKinnon's group reveal a glutamate side chain to the structure that potentially blocks the ion pathway. For th...Benefits from Alzheimer's plaque-producing reaction? Science study proposes role in gene expression
...ent of molecular machinery to unzip the DNA double helix and assemble a corresponding RNA chain. Certain molecules must bind to the "start" section of the gene's DNA sequence, and help provide a hookup to the rest of the transcription machinery. The Science authors found that the APP tail did help acti...Nanopore detector shows discriminating taste in DNA molecules
...wo strands that wrap around each other in a double helix resembling a twisted ladder. Each strand is a string of repeating units called nucleotides, and each nucleotide contains one of four "bases" (abbreviated A, T, C, and G). The rungs of the ladder consist of complementary pairs of bases, one from each ...A first: A (nearly) complete road map for the evolution of placental mammals
...s. Soon after the description of DNA as the double helix in the 1950s, scientists started using a completely new method to sort out such relationships: molecular genetics. This "molecular method" is similar to the traditional "morphological method" in that it makes decisions based on similarities and diffe...New study by scientists at the Scripps Research Institute
...s of 32 amino acidsthat naturally fold into a long helix and stick to another similar peptide, somewhat like the double barrels of a shotgun. They mixed right and left-handed versions of these peptides together with a mixture of their right and left-hand components. For the "template" peptides to replicat...Chemists describe "zipper teeth" of DNA molecules -- publish results in the journal Nature
... what they call the "zipper" that forms the double helix of DNA, the basic material of life. The article, "Pairing of Isolated Nucleic-acid bases in the Absence of the DNA Backbone," describes their discovery. "The coding of DNA is in the order of the base pairs," said Mattanjah S. de Vries, professor of ......eings. In dividing, the cell unzips the DNA double helix (consisting of two winding strands linked together by matching base pairs) using each strand as a template to direct the formation of its companion strand. Overseeing this process is a unique enzyme known as DNA polymerase, that "rides" on board the ...Fugu fish sequencing project potential boon to gene hunters
...ureate James Watson, co-discoverer of DNA's double helix structure, has endorsed this project. "The Fugu fish sequence, in combination with the draft mouse genome, to be available in early 2001, will greatly add to the comparative sequence studies that are now required to isolate coding and non-coding con...Canadian scientists find potent antifreeze protein that equips insects to brave winter
...avies and his colleagues describe the unusual beta helix structure of the antifreeze proteins, the secret t...d X-ray crystallography. The rather unusual beta helix structure of the antifreeze proteins of the spruce budworm and the mealworm beetle -- coil-like with...... of geometry, for the protein's preference for the helix as a major component of its overall structure," sa...al consequence of these two constraints alone is a helix with an equal amount of room both along the pitch axis of the helix and in the plane perpendicular t...New test for radiation damage to DNA developed at Brookhaven Lab
...aced breaks through both strands of the DNA double helix are known to be difficult for cells to repair. Scientists have also hypothesized that radiation might produce other forms of clustered damage on both DNA strands, like oxidation of the bases A, G, C, and T. Could these clustered damage sites be equal...DNA details suggest how human chromosomes break, rearrange and cause a genetic disease
...re inclined to protrude from the famous DNA double helix in fragile structures called hairpins. These hairpins are weak points where the DNA can break and rearrange, causing abnormalities of the chromosomes. When chromosomes 11 and 22 break, then exchange genetic material in a balanced translocation, ...Membrane protein research yields new insight into inner workings of the cell
...e patterns in the spectrum defines the tilt of the helix within the membrane. Indeed, it is possible to get this topological information on a helix without signal assignments -- the first time this has been possible in NMR spectroscopy. ...Chemical probe reveals ultrafast movements of DNA proteins
...obes to the outside of the DNA helix so the measurements they've gotten are not as precise, he said. Coleman and Madaras designed the probe on computer, then created it in the laboratory, along with a synthetic strand of DNA ...Argonne biochips may halt tuberculosis epidemic
...e helix." By fixing only one strand of the double helix to each gel pad, the chip takesadvantage of the natural tendency of each DNA base to pair with itscomplementary base. When tests begin, a sample of unknown single strands oftuberculosis DNA will be spread on a chip and allowed to naturally pair up in...Peering at a machine that pries DNA apart
...ed enzyme, or helicase, that unwinds theDNA double helix to expose its genetic letters for DNA replication.Michael Sawaya, postdoctoral fellow in the lab of Tom Ellenberger, associateprofessor of biological chemistry and molecular pharmacology (BCMP), worked outthe X-ray crystallographic structure reported......age inside a cell nucleus. DNA, the double helix of amino acids that constitutes the blueprint ofall life, has to be "naked" at certain points along its microscopic strand inorder for proteins to use it to replicate body cells. "All the information for every living cell is stored in DNA, w...Researchers take major step in identifying gene differences
...and C, paired in particular patterns in the double helix of our DNA. A SNPis a change in one of these letters that exists in some but not all humans. SNPs are particularly important for mapping and discovering genes associated with common diseases, which are caused orinfluenced by complex interactions amon...'Altered state' may be responsible for creating important brain chemicals
...d. Instead of looking like the right-handed double helix Watson and Crick haddescribed in 1953, the structure was a left-handed double helix with anirregular zig-zag backbone. Is this unusual form of DNA, dubbed Z-DNA by the research...... them, NERenzymes inspect each nucleotide of a DNA helix for any damage before another setof enzymes encounters this genetic material and replicates it prior to celldivision. In making their repairs, NER enzymes cut a large swatch of the helixaround a mistake and replace the damaged DNA with the correct s...