Antisense Therapy Prevents Burkitt's Lymphoma In Mice
... orientation. The complementary strand in a double helix is calledantisense. The antisense DNA drug attached to the sense RNA message preventsthe code from being read, so the disease gene can't produce the disease-causingprotein. In the lymphoma experiment, antisense DNAs were made to bind to RNA...Biochemist Solves Riddle Of Collagen Stability
...t "bridging water molecules" helps hold the triple helix together. In 1994, scientists showed for the first...obilize about 500 water molecules for every triple helix of collagen. Using synthetic chemistry, Raines' lab replaced the hydroxyl groups in collagen with fl...Long-Standing Puzzle Of Immune System Is Solved By UCSF Researchers
...cates its geneticmaterial, the double-stranded DNA helix unzips and each strand serves as atemplate for making new DNA. Sometimes the template is misread and thewrong building block is inserted into the new strand. DNA-repair enzymesthen step in to repair the damage before it becomes fixed. When......red areas)bound intimately to a twisted DNA double helix (pink and yellow areas). Wherethe double helix ends, the DNA continues as a short, single-stranded stretch(yellow), and this is where the polymeras......gles, strings of chemical "boxes" or even a triple helix but they have only been able to do so by assembling together expensive, carefully crafted, chemical building blocks (ligands) that they were 100% sure could do the job of assembling the final complex but useful structures. These carefully designed li...Study: Hydrogen Bonds Aren't Key To DNA Pairing After All
... H-bonds alone keep thetwo strands of a DNA double helix together, found in many textbooks, seems inadequate." The conclusion is based upon the finding that growingstrands of DNA can accurately incorporate a nucleotide thatclosely resembles the DNA base thymine but lacks the naturalbase's ability to f...Fast Measurement Technique Reveals Early Steps In Protein Folding
.... researchers have found that the initial steps of helix formationcan occur within several hundred nanoseconds. (A nanosecond is one billionthof a second.) The entire collapse to a compact structure appears nearlycomplete after just a few microseconds. "Unlike slower spectroscopic methods that are limited...New 'Twist' In Proteins Offers Possible Route To Improved Antibiotics
...re "right-handed." Thatis, when viewed end on, the helix spirals away in a clockwise direction. In ...Each subunit consists of a novel "left-handed"beta helix at the end called the NH2-terminal. The other end of the enzyme,called the COOH-terminal, features c...Enzyme's "Magic" May Hold Key to Anticancer and Antimicrobial Drugs
...DNA, severs it, passes a second DNA double helix through the resulting gap, then reseals the original DNA. The question is, how? Two theories prevail. According to the "one-gate" theory, DNA enters and exits the enzyme's active site through the same "gate." According to the ...