Tag: "helper" at biology news

Gene therapy for arthritis

... a similar strategy, transducing collagen-specific helper T cells with anantagonist of the cytokine IL-12. They introduce the modified T cells into mice that would otherwise develop CIAand show that the cells home efficiently to the synovium and block inflammation in situ. In contrast, their CNS-directedT c...

Epimmune scientists report positive pre-clinical data on vaccine designed to combat HIV's ability to mutate

...of cellular immunity, cytotoxic T-cells (CTLs) and helper T-cells (HTLs). Together, CTLs and HTLs comprise ...s HIV vaccine with its proprietary PADRE universal helper T-cell epitope. PADRE is an HTL booster which, when combined with CTL epitopes, enhances the magnit...

Human trials of new vaccine technique prove promising for allergy sufferers

...ce protective molecules from a different family of helper T cells (Th1), which inhibit the Th2 cells responsible for the allergic inflammatory reaction. "A therapeutic vaccine that maintains immunogenicity, or efficacy, while at the same time improving safety, would be a major advance in allergy shot ther...

Vaccine controls AIDS in monkeys, researchers report in Science

...s. Recent studies indicate that killer T cells and helper T cells play a critical role in controlling the replication of HIV and SIV in infected helper T cells in humans and monkeys. Hoping to increase the strength of the T cell response in some vacci...

New HIV model

...ystem by attacking white blood cells called CD4 or helper T-cells in the bloodstream. But Kirschner and Cloyd maintain that HIV's lethal action is much more subtle and indirect. Their model shows that CD4 cells actually self-destruct in the lymph system. Death comes as a result of exposure to biochemica...

Deadly to cattle and humans, prions may help other organisms survive, researchers find

...y of prions and does not require assistance from a helper protein, or chaperone. The specificity, the researchers found, results form a small, well defined region on the prion surface, makng it an attractive potential target for drugs to bind the prions and prevent them from spreading. In their experiments,...

Jellyfish protein illuminates active immune cells

...e facilitatorcells of the immune system--so-called helper T cells. When helper T cellsencounter foreign molecules, they kick the immune system into gear, alerting itto the presenc...

Heavy metal research is music to biologists' ears

... crucial for life--themetal copper is an important helper to many cellular enzymes, includingsuperoxide dismutase (SOD), which sops up dangerous "free radicals" thataccumulate inside cells. Defects in SOD have been linked to some inheritedforms of amyotrophic lateral sclerosis, also known as Lou Gehrig's d...

Scientists visualize key molecular interactions that activate the immune response to foreign proteins

...de complexes, are inspected by the immune system's helper T cells,which decide whether to mount a response t... Other researchers had captured snapshots of a helper T cell interactingwith an antigen-presenting cell through a shared protein structure. Dustin andcoll...

Key Peptides Found That Stop -- Even Reverse -- Kidney Disease In Lupus

...to inducetolerance or inactivate disease-causing T helper cells and B cells. T helper andB cells are the mediators of the body's immune response. Interestingly, the most effecti...

Rockefeller University Scientists Receive Prestigious Awards For Cancer Research

...merases) which directly copy DNA, their associated helper factors, and thefirst of many hundreds or thousands of gene- and cell-specific activators thatregulate their function on target genes. Dr. Roeder explained that over the years he has become increasingly interestedin the applications of his research. ...

Multicomponent Malaria Vaccine Shows Promise in Laboratory Tests

... different branches of the immune system: B cells, helper Tcells and cytotoxic T lymphocytes (CTLs). Laboratory tests showed that the vaccine induced a high level of antibodies thatrecognized the parasite at different stages of development. The antibodies alsoblocked P. falciparum invasion into the rabbits...

New Insight Into Genetic Cause Of Infant Mortality

... "Our research shows that SMN and its entourage of helper proteins are required for the proper form and function of snRNPs and for maintaining the splicing machine in an active form so that it can be used for multiple rounds of splicing," explains Dreyfuss. It turns out that healthy human motor neurons con...

Molecular Basis Of Leading Genetic Cause Of Infant Death Discovered

...Ps. Ourresearch shows that SMN andits entourage of helper proteins are required for the proper form and functionof snRNPs and for maintaining the splicing machine in an active form so that itcan be used for multiple rounds of splicing." In cells of patients with spinal muscle atrophy, the splicing p...

Researchers Identify How AIDS Virus Kills Cells It Doesn't Infect

... progress and response to therapy. High levels of helper T-cellsare a good sign; low levels are a sign of a... lose their CD8 T-cells,growth of the virus in CD4 helper cells is probably boosted, and more cells willbe killed," says Herbein, the study's lead author and ...

Security Code Helps Immune Cells Attack Foe And Spare Self

...titutes of Health. The researchers studied helper T cells, a key component of the cellularimmune sys...ks the door is: B1, C2, A1, A2, B2, C1. A helper cell becomes fully active only when all six phosphates are inplace. But the two resting-state phosph...

Baker's Yeast Causes Chemical Reactions And Sweet Smelling Labs

...vers and disease-causingbacteria. They also need a helper molecule, or co-factor, to perform areaction. Also, in current reactions, chemists use a chemical reagent as acatalyst, but those reagents are toxic and explosive. "We want to solve those practical problems and allow enzymes to be usedbyall c...

Fetal Lead Exposure May Reduce Immunity

...e lead-exposed rats had an overabundance of type-2 helper T-cell activity compared to type-1 helper T-cell activity, diminished production of gamma interferon, depressed cell-mediated immune function...

New Tuberculosis Vaccine Candidate Developed: Improved Delivery Of Antigens By Current Vaccine BCG (Bacille Calmette-Gurin)

...lity complex (MHC) class II-restricted CD4 T helper cells and MHC class I-restricted cytotoxic CD8 T cells are stimulated during M.tuberculosis infection, but the current BCG vaccine fails to prime CD8 T cells for tuberculosis prevention. Over the last few years, Juergen Hess and St...

Crystal Structure Of The Archaeal Chaperonin Thermosome, A Protein-Folding Machine, Determined

...haperonins 10, termed GroES in E. coli . These helper molecules are not present in the group II system. Whereas detailed structural studies were available for group I chaperonins, including the atomic model of the GroEL-GroES complex, such structural information was not available for members...

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