Tag: "hippocampus" at biology news

Sleep deprivation within five hours of learning impairs memory consolidation in mice

...ued memory, was not affected. Because the brain's hippocampus is key to contextual memory but not cued memory, the findings provide new evidence that sleep helps regulate neuronal function in the hippocampus. Abel's group studied fear conditioning in mice. Animals received a mild electric shock in conjunction ...

How old mice get bright again

... brain tissue of aged mice when compared to LTP in hippocampus of young mice. Moreover, using specific antibodies...tassium channel, the so-called SK3 channel, in the hippocampus of aged, but not of young mice. Most strikingly, when the researchers selectively downregulated SK3 ...

Creation of new neurons critical to antidepressant action in mice

Blocking the formation of neurons in the hippocampus blocks the behavioral effects of antidepressants i...ction, Hen and colleagues selectively targeted the hippocampus with x-rays to kill proliferating cells. This reduced neurogenesis by 85 percent. Antidepressants ha...

As autumn approaches, this chickadee's brain begins to expand

...rcent by adding new nerve cells. In songbirds, the hippocampus is located on the dorsal surface of the forebrain right beneath the skull. In mammals, the hippocampus is located beneath the cortex. In the spring, when its feats of memory are needed less, the chickade...

Can heart failure impair thinking?

...ion suggests specific neural damage related to the hippocampus or frontal lobe or associated circuitry, rather th... inferior temporallobe cortical area bordering the hippocampus showed gray matter loss. Cingulate gyrus, dorsal midbrain, and thalamus: The right cingulate cortex...

Gene controls age at onset of Alzheimer's and Parkinson's diseases

... disease by comparing the activity of genes in the hippocampus -- a part of the brain affected by the disorder -- of unaffected individuals and Alzheimer's patients. The experiment uncovered four genes, including GSTO1, located in the region of the genome earlier linked to age at onset, the researchers report. A...

Diet may improve cognition, slow aging, and help protect against cosmic radiation

...sential role in learning and memory. Damage to the hippocampus results in an inability to remember recent events. The researchers then tested the animals' ability to learn a complicated maze task. The rats that had been fed the blueberry extract were significantly less impaired at performing the task than those ...

Can EPO prevent loss of brain function in schizophrenia?

..., where binding sites are densely expressed in the hippocampus and cortex, and (3) peripherally administered erythropoietin enhances cognitive functioning in mice in the context of an aversion task involving brain circuits believed to be affected in schizophrenic humans. First results of the multicenter trial ru...

Gene essential for development of normal brain connections resulting from sensory input discovered

...brain develops normally, but then shuts off in the hippocampus when the mice reach adulthood. In this way, the researchers can test the specific role of CREST in learning and memory in adults. "Humans also have CREST, and the CREST gene sequence is highly similar between mice and humans," says Ghosh. "If it tu...

Research reveals brain has biological mechanism to block unwanted memories

...y), which in turn led to reduced activation of the hippocampus (the part of the brain used to remember experiences). In addition, the researchers found that the more subjects activated their frontal cortex during the experiment, the better they were at suppressing unwanted memories. "For the first time we see so...

Genetic screening recommended to detect new neurodegenerative disorder in men over age 50

... regions. The greatest densities were found in the hippocampus and frontal cortical regions, areas of the brain that control movement and are important in learning, memory and emotion. "The formation of inclusion bodies in the nuclei of nerve cells offers an important clue about the cause of the disorder, one...

Small amounts of alcohol or anesthetics may damage the developing brain

...al currents through neuronal slices taken from the hippocampus to induce a process known as long-term potentiatio...ted with an LTD stimulus, normal slices of the rat hippocampus experience a 30 to 40 percent decrease in synaptic transmission. But those rats treated with alcohol...

Mix of chemicals plus stress damages brain, liver in animals and likely in humans

... cerebral cortex (motor and sensory function), the hippocampus (learning and memory) and the cerebellum (gait and coordination of movements). Abou Donia's earlier studies demonstrated severe damage to the cingulate cortex, dentate gyrus, thalamus and hypothalamus.(The thalamus is the major relay for visual and a...

Scientists discover why not enough choline results in fewer brain cells, poorer memory

...deficient diets. The latter showed deficits in the hippocampus and septums of their brains. Because humans and rodents are so similar biologically, something comparable probably happens in humans, the investigators believe. Now, working with nerve tissue derived from a human cancer known as a neuroblastoma, the ...

JCI table of contents, 2 April 2004

...ous work has indicated that loss of neurons in the hippocampus after seizures may be due to onset of programmed c...tally-produced prolonged seizures that damaged the hippocampus in rats, Bim expression increased. Blocking upstream activators of Bim or using Bim antisense to bl...

Bim notes in the neuronal executioner's song

...ous work has indicated that loss of neurons in the hippocampus after seizures may be due to onset of programmed c...tally-produced prolonged seizures that damaged the hippocampus in rats, Bim expression increased. Blocking upstream activators of Bim or using Bim antisense to bl...

UCLA scientists decipher how the brain retrieves and stores our oldest memories

...ntias. "Scientists have long understood that the hippocampus processes recent memory, but we did not know where...fen School of Medicine at UCLA. "We knew that the hippocampus did not store memories permanently. "Most people define memory as their collective lifetime experien...

Leptin has layers of control

...e form. In cell culture of neuronal cells from the hippocampus (the area of the brain where leptin acts), leptin treatment led to a significant increase in the expression of these two enzymes at both the genetic and protein level. Rats that were starved, and thus had low levels of leptin in their blood serum le...

JCI table of contents, 2 August, 2004

...e form. In cell culture of neuronal cells from the hippocampus (the area of the brain where leptin acts), leptin treatment led to a significant increase in the expression of these two enzymes at both the genetic and protein level. Rats that were starved, and thus had low levels of leptin in their blood serum lev...

Early clinical treatment can halt progression of Alzheimer's disease, UCI researchers find

...administered anti-beta-amyloid antibodies into the hippocampus one of most critical brain structures involved in learning and memory of the mice and found that the amyloid plaques were cleared by three days, followed two days later by the clearance of the lesions caused by neurofibrillary tangles. Thirty days ...

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