JCI table of contents September 15, 2004
...rupt Cholesterol TITLE: Disruption of cholesterol homeostasis by plant sterols AUTHOR CONTACT: Helen H. Hobbs University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA Phone: 214-648-6724; Fax: 214-648-7539; E-mail: helen.hobbs@utsouthwestern.edu View the PDF of this artic...JCI table of contents, 2 August, 2004
... Sugar Baby Lacks Control TITLE: Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM AUTHOR CONTACT: Gavin Kelsey The Babraham Institute, Cambridge CB2 4AT, UK Phone: 44-1223-496332; Fax: 44-1223-496022; E-mail: gavin.kelsey@bbsrc.ac.uk View ...Good bacteria trigger proteins to protect the gut
...ng TLRs to control genes and processes that foster homeostasis of intestinal epithelium, which confer a protective effect on these cells and induce tissue repair." According to Medzhitov, TLRs may work both by a continual recognition of commensal bacteria and by responding to damage to initiate a repair process....Obesity and hypertension: Two epidemics or one?
...e heart, plays an important role in cardiovascular homeostasis by modulating vascular tone, inhibiting monocyte and platelet adhesion, and maintaining fibrinolytic balance. In obesity, the endothelium is exposed to mechanical forces and other cardiovascular risk factors that can alter vascular structure and func...Study is another step in determining if curry can protect against Alzheimer's
...ll systems has the possibility to restore cellular homeostasis and resume the ability to fight off oxidation. Activation of antioxidant pathways is particularly important for tissue with relatively weak antioxidant defenses, such as the brain. In fact, increasing evidence points to the notion that reduced cellul...Scientists' findings may lead to better understanding of how that sleep develops, matures
...lts. The results suggest that EEG markers of sleep homeostasis appear in the first postnatal months and that sleep homeostasis goes through a period of maturation. A New Study The authors of the new study, entitled "Developm...OHSU-led research examines role of copper, iron in diseases
...irst in the nation to focus on understanding metal homeostasis in human cells and its disruption not just in Wilson's and Menkes diseases, but also diseases such as hemochromatosis, Lou Gehrig's disease and even mad cow disease, all of which may be linked to errors in metal metabolism. The research explores mol...JCI table of contents, January 2, 2004
...f angiogenesis. TITLE: Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo AUTHOR CONTACT: Kather...ldren, however the mechanisms regulating pulmonary homeostasis are poorly understood. In the January 2 issue of the Journal of Clinical Investigation, Jeffrey Whit...OHSU team discovers compound that lacks estrogen's risks
...us "controls all autonomic functions and maintains homeostasis eating, drinking, sex behavior, maternal and even paternal behavior," Kelly said. In particular, hypothalamic POMC neurons, which are especially sensitive to STX, "are what activate the natural reward pathways. This is the brain's endogenous opiate ...Alcohol exposure in pre- and early post-natal stages may cause insulin resistance
...ncy, may program the offspring to abnormal glucose homeostasis later in life. Further, EtOH exposure during the prenatal or early postnatal period resulted in insulin resistance and glucose intolerance later in life. The underlying mechanisms are still unknown, however, and require further investigation....A new hope for heavy metal contaminated soils
...rabidopsis thaliana, thereby identifying key metal homeostasis proteins. These could serve as a basis for the dev...ly knit and intricately regulated network of metal homeostasis proteins. Existing knowledge of these proteins show a surprising extent of similarity between metal ...New understanding of insulin's complexities needed to conquer diabetes
...gulates brain growth, body-weight control, glucose homeostasis and female fertility, researchers have found. The IRS2 branch of the pathway might be a linchpin to understand the link between obesity, insulin resistance and beta-cell failure that causes type 2 diabetes. "We found that IRS2 not only mediates insul...JCI Table of Contents, November 3, 2003
...Colletti and colleagues suggest that while hepatic homeostasis and regeneration likely involves multiple complex mechanisms and pathways, their current report indicates that SCF plays a significant role in maintaining and reestablishing the health of the liver. TITLE : Stem cell factor restores hepatocyte prol......idence for a bone-kidney axis regulating phosphate homeostasis AUTHOR CONTACT: L. Darryl Quarles Duke University Medical Center, Durham, North Carolina, USA Phone: 919-660-6853 Fax: 919-684-4476 E-mail: quarl001@mc.duke.edu View the PDF of this commentary at: https://www.the-jci.org/press/19687.pdf *******......afe as there have been reported effects on glucose homeostasis (the regulation of blood sugar levels) and potential subjects with a medical history of diabetes were excluded from the experiment. In addition taking the supplement can have some antisocial effects. "To be frank taking the supplement can make you a ...Can female adult obesity be stopped at birth?
... obesity? Perhaps. Background The body's energy homeostasis is maintained by a highly complex and integrated neurohormonal system that minimizes fluctuations in energy balance. Neurohormones are formed by neurosecretory cells and liberated by nerve impulses (e.g., norepinephrine). Their contribution towards t...Chronic alcohol abuse damages regulating hormones
...uring withdrawal, changes in electrolyte and water homeostasis occur. We know that the interaction of different ...ly contribute to recovery of water and electrolyte homeostasis but also benefit cognitive functions such as memory. The findings of the present study imply that a...Researchers pinpoint cause of inherited form of heart failure
...nk would very much benefit from modulating calcium homeostasis in heart cells," said Seidman. Additional research might well reveal that defects in calcium cycling could underlie some forms of hypertrophic cardiomyopathy, which are believed to be a very different type of failure in the contractile apparatus, sai...Scientists make a BID towards understanding chronic myelomonocytic leukemia
... is required for apoptosis -- and thus the overall homeostasis -- of myeloid (bone marrow-derived) cells. BID-deficient mice experienced an overexpansion of myeloid cells (myeloid hyperplasia) and ultimately succumbed to a form of leukemia closely resembling human chronic myelomonocytic leukemia (CMML). In fact,......significant role in human adipogenesis and insulin homeostasis than it does in rodents, as there is no IRS-3 to compensate for mutations in, or loss of, IRS-1. In light of this, the IRS-1/3 double knock-out mice "may more closely mimic what happens in humans when the levels or sequence of IRS-1 is altered (since...