Molecular staples shape a cancer killer
...s tested the effects of SAHB on mice that harbored human leukemia cells. "We found that SAHB treatment effectively suppressed leukemia in these mice," he said. According to Walensky, the experiments are the first steps in a broader effort to construct hydrocarbon-stapled alpha-helical peptides that affect...Diabodies act as guided missiles targeted to mammary tumor growth
...d of tumor-busting radiation thwarts the growth of human breast cancer in laboratory animals, according to ...d antibodies that specifically target the HER2/neu human tumor-associated antigen. When loaded with the beta-emitting radioisotope yttrium-90, C6.5K-A signif...Computer models expose humans as main cause of caribou decline
...ges from current conditions. The models show that human activities stood out overwhelmingly as the variabl...olled wolf populations in northern Alberta, but if human developments continue at the current rate, the number of woodland caribou in the area will drop shar...Essential smell gene may provide key to new insect repellents
...thus prevent disease-carrying insects from finding human hosts, might eventually help fight malaria and oth...fever, and West Nile encephalitis, and they locate human hosts largely through their exquisitely sensitive olfactory systems." "We need better insect repell...Flame retardants found on supermarket shelves
... in fats, so they tend to accumulate in animal and human tissues. Only two other similar market basket s...flame retardants, but their increasing presence in human tissue is cause for concern because they have been associated with cancer, endocrine disruption and ...Men from early middle ages were nearly as tall as modern people
...nded by the National Science Foundation to analyze human health throughout the past 10,000 years. Steckel wants to continue looking at, and interpreting, fluctuations in height across thousands of years "I want to go much further back in time and look at more diverse populations to see if this general rela...DHA-rich diet protects brain from Alzheimer's damage, UCLA study shows
...tervene with treatment sooner," noted Cole. The human brain absorbs DHA rapidly, making a constant supply critical for proper cognitive function, eye development and mental tasks. DHA helps keep the brain membrane fluid, moves proteins and helps to convert signals from other parts of the body into acti...Zoledronic acid zings cervical cancer
...mouse model had several characteristics similar to human cervical cancer. They further found that an important player in cervical cancer progression was an enzyme called matrix metalloprotease-9, which stimulated angiogenesis. The researchers treated these mice with bisphosphonate, zoledronic acid, a matr...Study reveals first genetic step necessary for prostate cancer growth
...rous condition analogous to the earliest stages of human prostate cancer. Importantly, in the absence of ad...ety of cancer types, including up to 60 percent of human prostate cancers. Rb is a member of a family of genes known as tumor suppressors, which normally wor...Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
... unprecedented picture of how bacteria latch on to human cells has been published by UK, French and US scie...or responsible for regulating one of the important human immune responses, known as Decay Acceleration Factor, or DAF. "Cell adhesion is one of the first con...Pig-human transplantation not PERVerted
...ssess the ability, though limited, to replicate in human cells. So far, the actually frequency of PERV tran...atients or animal models under circumstances where human cells are exposed over a long term to similar amount of pig tissue. Yong-Guang Yang and colleagues,...Convulsions in worms mimic epileptic seizures
...ied worms with a mutation in the LIS1 gene. In its human form, the gene has been linked to a rare birth def...ecular Genetics, published online August 31. "The human brain has 100 billion neurons, whereas the worm has only 302. We know each type of neuron and how th...New imaging technology at Joslin shown to detect early signs of type 1 diabetes
...en used safely and effectively by the MGH group in human clinical trials to detect the spread of prostate cancer to the lymph nodes. "Given the known safety of magnetic nanoparticles in humans, the technology might someday be used in individuals who are genetically at risk for diabetes to detect this auto...... activated, is known to be involved in a number of human cancers. Here researchers used a two-stage chemical skin cancer mouse model to investigate whether Stat3 is involved in one of the most common forms of cancer, and if so, at what stage. They found that while a normal mouse, after chemical treatmen...JCI table of contents: 1 September, 2004
...mouse model had several characteristics similar to human cervical cancer. They further found that an impor... activated, is known to be involved in a number of human cancers. Here researchers used a two-stage chemical skin cancer mouse model to investigate whether ...Researchers identify the genome's controlling elements
... may soon contribute to a new way of understanding human health and disease. "This is really the next stage in human genome research," says Whitehead Member Richard Young, who headed the project together with Whitehea...Analysis of gene expression in lymphoid cells can determine lymphoma cancer
...mbers of this kinase family. "We were screening a human DNA library in order to look for members of this f... Rb2/p130. "Our studies have demonstrated that in human tissue, CDK9 is a very important player in specialized tissue, as we see in this study with lymphoid...Scientists discover proteins involved in spread of HIV-1 infection
...quence of amino acids which it uses to recruit the human tumor susceptibility gene 101 (TSG101). The virus ...is not quite as defined--scientists have found the human equivalent of Vps28p, but not Vps37p. Missing this protein has made it hard to understand what exact...NHGRI launches Centers for Excellence in Ethical, Legal, and Social Implications Research
...dy the ethical issues in the design and conduct of human genetic research, including issues regarding the protection of human subjects in research. After first surveying existing ethical, legal and social implications research...Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
... a professor in the department of food science and human nutrition. "We were surprised and pleased to find...vention, and Jackson exposed cultures of malignant human breast cancer cells to SUL. Within hours, SUL blocked cell division and disrupted microtubules, whi...