Tag: "hurdle" at biology news

Trojan Horse Virus Controls Hiv Infection

...all. She adds, "The Yale group has crossed a major hurdle that may allow direct, invivo delivery of a vector that can find its destined target in the body. Thereshould be no need for ex-vivo manipulation of cells." She envisions manypotential applications of this research. Surface-modified live vectors li...

Research Aims At Nation's First 'Smart' Ground Water Regulations

...d the realm of the possible, there will be another hurdle to clear before smart regulations are put into use, however. Those hurdles are all political, and they may prove to be the most difficult of all. "If 'smart' regulations are to be used, assumptions that were implicit in the old regulations would beco...

First TableTop Source Of Concentrated X-Rays Built

...ollow fiber at the samespeed as the laser. A major hurdle for earlier attempts at such a setup was that the X-rays tendedto cancel each other out, much like overlapping water waves neutralize eachother if their peaks and troughs coincide. The canceled waves produce very dim,diffuse X-ray patterns on the de...

Fossil Eggshells Hold Clues To Major Animal Extinctions As Reported In Science

...of radiocarbon dating. Miller's group cleared this hurdle when they documented the timing of theextinction of Genyornis newtoni , a ponderous flightless bird with thick, shortlegs that weighed around 200 pounds--twice as much as the modern day emu. Theyused a variety of alternative dating techniques (not b...

Duke scientists reverse a rare form of muscular dystrophy in mice using gene therapy

... to all themuscles in the body, which is the major hurdle to overcome in designing genetreatments for muscle...ation of a gene therapy vector" Amalfitano said,"a hurdle that has always made the potential of gene therapy to treat musclediseases very difficult to envisio...

Researchers overcome hurdle of transporting large amounts of DNA to the nucleus using nonviral vectors

...somes and becarried to the nucleus. "It's the next hurdle of transporting the DNA into thenucleus that we've essentially catalyzed," says Diamond. His approach is to deliver DNA using lipoplexes, a lipid complexed to plasmidDNA, a simple, circular form of the genetic material. Specifically, theydelivered...

Gene tracking follows cells from embryo to adult

...ar radar screen. The research team overcame this hurdle by modifying the Wnt1 reporter gene so that it became a switch, turning on a second reporter gene that remained active even after Wnt1 reverted to dormancy. The second gene, called ROSA26, is turned on only in cells where Wnt1 was initially active--...

Give it a thought -- and make it so

...person is looking at in the virtual room, the next hurdle will be to devise a system that can tell what object a person is looking at in the real world. BCI groups are also close to surmounting another obstacle-that of attaching the sensors to the head. Right now dozens of electrodes must be attached to the...

Scientists bypass major hurdle to hemophilia gene therapy

Scientists bypass major hurdle to hemophilia gene therapy; animal studies yield h...gs and humans. "Our new research bypasses a major hurdle in gene therapy for hemophilia, but it also represents the beginning of a long series of experiments...

New technique answers one of waters basic mysteries

...roven algorithm to model the process, but the real hurdle lay in the rarity of the event itself. "If we just set up the algorithm and let it run, we would have waited many times the age of the universe for something to happen," says Dellago. Devising a way to "zoom in" on just the single moment when the str...

Finding a model, finding a cure

A major hurdle in the development of an animal model of hereditary breast cancer in humans has been overcome. Breast cancer is the most prevalent type of cancer in women, with 192,000 new cases expected this year in the US alone. Despite extensive research efforts,...

Scientists find heavy HIV levels in patient fluids less than 30 days after start of flu-like symptoms

... sexual partners, the physician said. However, one hurdle to diagnosing very early infections is that routine antibody tests to HIV are likely to be negative during this period. It's necessary to use other, more sophisticated tests such as polymerase chain reaction to directly detect the presence of the vir...

'Smart bandage' diagnoses danger before infection takes hold

...g in the case of biowarfare," he says. The biggest hurdle to the development of the smart bandage is now cleared. "We've shown that we can detect and identify a single, distinct kind of bacteria," says Miller. "Now that we have that out of the way, we know it can be done. Finding the molecules to detect oth...

Stanford researchers develop system for field testing mechanisms of evolution

...f. - Evolutionary biology has always faced a major hurdle - how to test a process that takes place over thousands, if not millions, of years. Researchers at Stanford University may have come up with a solution. Genetic mutations and the possible mechanisms underlying evolution have been studied in la...

US researchers successfully clone first knockout miniature swine

...represents advancement towards an important safety hurdle for xenotransplantation. "We have been actively developing a line of miniature swine that offers many advantages as a potential donor for xenotransplantation, including their organ size, which is appropriate for human recipients" said Julia Greenstei...

USF neuroscientists study potential of cord blood cells to rescue aging brain

...eurons is a big step. The much bigger and trickier hurdle is getting them to behave like neurons in the brain. The USF study will use a model of aging rats to test the following: Which growth and nutritional factors best prompt malleable HUBC cells to follow pathways that lead the immature cells to become...

Scientists produce the script for life

...ks what would have taken years to achieve. "A key hurdle we had to overcome was assembling snippets of conversation between genes into a coherent script. We developed new computational techniques, which allowed us to discover the script, visualize it over time, and to check it for accuracy," explains Giff...

JCI table of contents, December 15, 2002

...dy-mediateddestruction of donor tissues is a major hurdle of pig-to-primate organtransplantation. One way to avoid this problem is to sequester thecirculating [alpha]Gal antibodies and thus prevent them from binding to anddestroying the donor tissue. Andreas G. Katopodis and colleagues developed asoluble [a...

Data presented on first cloned, double knock-out miniature swine

...ounted by the human immune system has been a major hurdle in this research. A key player in this rejection process is the gene called a-1,3-galactosyltransferase or GGTA1 that produces a sugar molecule. When a foreign organ is introduced, human antibodies attach to the sugar molecule on the surface of ...

Prion disease may be caused by buildup of cellular trash, say Stanford researchers

...Now He and her colleagues face their next research hurdle in their attempt to connect the dots leading to neuronal degeneration and death: identifying the natural target for Mahogunin. Additional collaborators include Stanley J. Watson, Jr., MD, PhD, professor of psychiatry, and Xinyun Lu, PhD, research inv...

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