Tag: "hurdle" at biology news

Immune response depends on key molecule: Research

...s without the molecule. Researchers overcame this hurdle by targeting and eliminating caspase-8 from specific organ tissues in mice, enabling them to see how these tissues are affected by the absence of caspase-8. "The research we've done has created a unique model that we and other scientists can use to f...

Purdue biologists crystallize technique to expand protein research

...n, an accomplishment that could overcome a 20-year hurdle in fighting a wide range of diseases. William Cramer and three other scientists have tackled a major problem confronting protein researchers - how to crystallize fat-soluble proteins in order to study them. Most proteins are water-soluble and form c...

Ovarian tumor cell sensitivity then resistance - to chemotherapy linked to genetic abnormality

...herapeutic agents." The finding represents both a hurdle to the development of new anti-cancer drugs and, paradoxically, a crucial step toward the discovery of such drugs. Scientists working on drug development now know that they are chasing more of a moving target than they may have realized. They also ha...

Drug-resistant cancer outwitted by chemical flank attack

...tance to Gleevec, have shown that this therapeutic hurdle can be overcome by administering a second drug that foils the cancer in a novel way. The experiments constitute a proof-of-principle that resistance to Gleevec can be defeated by using a second drug to shut down the activity of the drug's main target...

University of Idaho, Utah State University team first to clone equine

...eat, signifying the team had crossed a significant hurdle in the experiment. That year, researchers transferred 84 eggs, establishing five apparent pregnancies. "The results were impressive and immediate," Woods said. The first change led to a significant advance in the development of cloned embryos. In 200...

'Immortalized' cells enable researchers to grow human arteries

...to functional arteries. The key to overcoming this hurdle was found in a cancer research lab. Every time a cell divides, the ends of its chromosomes, or telomeres, erode until they become so short that the cell receives a signal to stop growing. While at the Massachusetts Institute of Technology, current Du...

Neural stem cells take a step closer to the clinic

...f genes that influence immune response. A critical hurdle for any cells or tissue used in transplants is finding ways to get around the body's immune system, which targets foreign cells and tissue for rejection. Through genetic manipulation, it may be possible to create cells that fool the immune system, ob...

Straight talk: Adult and embryonic stem cells and the future of research

...er that question, and we won't for some time." One hurdle to understanding the differences between embryonic and adult stem cells is political indecisiveness, says Civin, who will open the AACR session by describing a current effort in the Maryland legislature. A proposed bill would try to make Maryland an ...

Key advance reported in regenerating nerve fibers

.... "But then we come to another big hurdle." That hurdle is getting the nerve fibers from the eye to hook up to the correct centers in the brain in such a way that visual images do not become scrambled. "It's a mapping problem," Benowitz said. "We have to retain the proper organization of fiber projection...

Dana-Farber scientists discover natural blocker of HIV-1 virus

...ues, and mangabeys from Africa and Asia) and is a hurdle to making models of human AIDS in these monkeys. Authors in addition to Stremlau and Sodroski are Christopher Owens, Michel J. Perron, and Michael Kiessling, of Dana-Farber, and Patrick Autissier, PhD, of Beth Israel Deaconess Medical Center....

Hopkins scientists overcome main obstacle to making tons of short, drug-like proteins

...ptides quickly and efficiently, overcoming a major hurdle to creating and screening huge "libraries" of these super-short proteins for use in drug development. "Our work dramatically increases the complexity of peptide libraries that can be created and the speed with which they can be made and processed," s...

Soybeans may reduce risk of colon cancer

...er-fighting substances reach the cells is always a hurdle in any kind of cancer research. Cancer is most often found in cells that experience rapid division, such as gastrointestinal, skin, lung and breast cells, explained Merrill. As the cells divide, mutations can occur that alter the function and chemist...

Purdue study finds antioxidant protects metal-eating plants

...m the damaging effects of those metals. "One major hurdle to developing hyperaccumulating plants is toxicity," said John Freeman, first author of the paper and a doctoral student working with Salt. "For a plant to hyperaccumulate metal, it has to be able to tolerate metal toxicity." A nearly ubiquitous ant...

Optimizing protein's 'death domain' halts leukemia in laboratory study

...s the foundation for building novel drugs. But one hurdle loomed. When the helical "death domain" is removed from its parent protein, it loses its rigid shape, becoming floppy liked an overstretched Slinky. In this form, it is vulnerable to degradation, unable to enter cells, and left powerless to block the...

Green, leafy spinach may soon power cellphones and laptops

...n Chemical Society. "We have crossed the first hurdle of successfully integrating a photosynthetic protein molecular complex with a solid-state electronic device," Baldo said. Plants' ability to generate energy has been optimized by evolution, so a spinach plant is extremely efficient, churning out...

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