New drug shows promise against Gleevec resistance in mice
...a hybrid BCR-ABL enzyme that is always active. The hyperactive BCR-ABL, in turn, drives the overproliferation of white blood cells that is the hallmark of CML. In the studies published in Science , Sawyers and his colleagues demonstrated that BMS-354825 prolongs survival of mice with CML. In tests wi...From lung to gut the Wnt signaling pathway transforms cell fate
...dermis and hair follicle. "These results show that hyperactive Wnt signaling in lung progenitor cells can induce a dramatic shift in lineage commitment and the generation of intestinal cell types," write the authors. Understanding the mechanism by which these progenitor cells can switch their fate and create oth...Antibiotics alter GI tract microbes and increase lung sensitivity to allergens
...spores, pollen or other allergens. The result is a hyperactive immune response, which can produce allergy symptoms or even asthma. To test Huffnagle's hypothesis, Mairi C. Noverr, Ph.D., a U-M research fellow in internal medicine, gave a five-day course of oral antibiotics to normal lab mice followed by a single...Protein keeps cold fish from becoming frozen flounder, new study shows
...ree decades. "Prior to this we had only found such hyperactive antifreeze proteins in insects," says Dr. Davies. ...lications could be realized with concentrations of hyperactive AFPs 10 to 100-fold lower than would be required with the previously discovered fish AFPs....Ritalin may improve Parkinson's symptoms, OHSU study says
PORTLAND, Ore. A well-known drug used to treat hyperactive children boosts the potency of another drug that reduces Parkinson's disease symptoms, an Oregon Health & Science University study has found. Scientists at the OHSU Parkinson Center of Oregon found that methylphenidate, known commercially as Ritalin,......lution when our small, long-nosed, bewhiskered and hyperactive ancestors were breaking out of the understory role that they had occupied during the age of the dinosaurs to claim niches that were abandoned as the "thunder lizards" died out. Using a technique called "in vivo optical imaging," a team of researcher...Combination therapy drives cancer into remission
...as that resulted from transplanted cells producing hyperactive Akt protein were pathologically indistinguishable ...the molecular diagnosis of which gene products are hyperactive or inactive in a particular tumor. Moreover, the study indicates that existing drugs believed to be ...Drug addiction, learning share common brain protein
...orted. Mice deficient in PSD-95 also became more hyperactive than normal mice following cocaine injection, further linking the protein to the drug's brain effects. However, the deficient mice failed to gain further sensitivity upon repeated cocaine exposure, as mice typically do. "Drug abuse is a complex di...High heart risk for lupus patients linked to death of cells lining blood vessels
... disease causes the body's immune system to become hyperactive and form antibodies and immune complexes that attack normal tissues and organs. The disease can cause sporadic periods of fatigue, pain, organ damage and disability that persist for years. Many patients die prematurely of kidney failure, infection or...Stem-like cells from peripheral blood restore function in rats with severe stroke
...d that, following cell therapy, the stroke-induced hyperactive behavior of the rats was reduced to a pre-stroke level of normal activity. The improvement was similar whether the rats had been treated with peripheral blood cells or HUCB cells. Unlike humans, who are often paralyzed following a severe stroke, rat...Distinctive genetic program guides breast cancer's deadly spread
... happen to accumulate the 'winning combination' of hyperactive genes that enables them to thrive in bone marrow. And once the traveling tumor cells pass through bone marrow, they are incredibly successful at attaching to and invading bone." According to Massagu, additional studies will be required to understand ...Researchers find protein mechanism for potential atherosclerosis development
...ics and first author of the study. This process is hyperactive in atherosclerosis. The absence of LRP1 is unlikely to occur in humans, Herz said, but the research emphasizes the importance of PDGF signaling in the development of atherosclerosis. Atherosclerosis is a buildup of cholesterol and fatty substances i...ADHD in a SNAP: The SNAP gene in attention deficit hyperactivity
...es have shown that the coloboma mouse mutant has a hyperactive phenotype similar to that of ADHD. This model was shown to be the result of a deletion of the SNAP-25 gene. This deletion may have a direct consequence on the neurotransmitter release that has been implicated in the susceptibility to ADHD. DNA varia...Study identifies hypertension patients who can benefit from the little used diuretic amiloride
...to test the hypothesis that specific inhibition of hyperactive ENaC with amiloride could improve hypertension. To test their assumption, the researchers obtained blood samples from patients with normal blood pressure and hypertensive patients. Volunteers were between ages 19 and 70 and were recruited from the ...Prof. Shmuel Ben-Sasson wins first prize in Kaye Awards
... functioning, however, when protein-kinases become hyperactive or underactive in many cases a disease develops. Using his unique bioinformatic tools, Prof. Ben-Sasson was able to determine how the activity of protein-kinases is controlled and then design a method to produce synthetic compounds that can activate ...Rats depleted of salt become sensitized to amphetamine, show unusual growth of brain cells
...nsitized to amphetamine, exhibiting an exaggerated hyperactive response to the drug and an unusual pattern of neuronal growth in a part of their brains, neuroscientists have found. The researchers, headed by University of Washington psychologist Ilene Bernstein, discovered that nerve cells in the nucleus accumb......y of the same diseases, including atherosclerosis, hyperactive airways, and high blood pressure," Dr. Peters explains. "At The Jackson Laboratory, our knowledge of the mouse genome makes it possible for us to analyze complex human diseases, using powerful new genetic and molecular techniques to identify genes an...UF researchers find painless electrical stimulus helps restore hand movement for stroke patients
... muscles that are weak contract, so those that are hyperactive -- the ones that bend the elbow, wrist and fingers -- don't simply take over, making it harder for patients to use their arms at all and leading to more pain and discomfort," Wolf said. Cauraugh speculates the electrical impulses may help reactivate...Genetic, Familial Factors Influence ADHD, Not Necessarily Sex Of Child
...ay be that what we once thought of as the strictly hyperactive and impulsive group is very rare or isreally the combined type, and treatment for ADHD would improve both problems.But we found good evidence for only two subtypes." By including twins in the study, the investigators were able to determine thatgenes......hey will endure reduced learning capacity and hyperactive behaviour, showing irreparable brain damage. Other toxic pollutants, such as PCBs and brominated flame retardants, can also cause similar effects even in small doses. "Are human babies as sensitive as young mice? We do not know,...