Tag: "hypertrophy" at biology news
Gene therapy alternative to calcium channel blockers
...els of calcium can lead to arrhythmias, as well as hypertrophy
(uncontrolled growth of muscle tissue), apoptosis (programmed cell death) and cardiac remodeling. "Our hope is that further research and eventually human clinical trials will prove the benefits of gene therapies for the treatment of other ailments,...
Endurance exercise found to be equally effective as diuretics in improving cardiac health
...rbidity and mortality in old age. Left ventricular hypertrophy
(LVH), or an enlarged heart, is commonly observed in a patient with hypertension and can be a powerful predictor of heart failure independent of level of blood pressure (BP) in hypertensive adults. Reduction of blood pressure during contraction can ...
Obesity and hypertension: Two epidemics or one?
...hypertension worsen the degree of left ventricular hypertrophy
in a synergistic manner, and this translates into ...ts of the cardiac dysfunction and left ventricular hypertrophy
observed in obese individuals. The degree of cardiac dysfunction and left ventricular hypertrophy
Link between alcohol consumption and muscle damage in females
...poptotic effect, a compensatory stimulus to induce hypertrophy
to counteract the catabolic effects of alcohol, or even a nonspecific cellular stress response to alcohol and/or acetaldehyde. Contrary to expectations, neither p53 nor Bcl-2 mRNA levels were affected by alcohol, even in the presence of cyanamide pre...
Researchers show absence of key oxygen-sensing molecule leads to developmental defects
...searchers reported abnormalities including cardiac hypertrophy
or enlarged heart, fatty liver, eye defects, serum biochemical abnormalities, and increased oxidative stress conditions seen in human patients with mitochondrial defects. "The surprise was that mice lacking the nuclear DNA-encoded Epas1/HIF-2 had c...
Investigational cancer drug prevents abnormal brain growth, reverses seizures in lab mice
...multiforme." Lhermitte-Duclos disease is caused by hypertrophy
(enlargement) of the granule cells in the cerebellum, which results in headaches, movement disorders, tremor and other problems. Ataxia is a loss of muscle coordination which can be seen as the inability to walk normally. Glioblastoma multiforme is a...
JCI Table of Contents, November 3, 2003
...The anti-oxidant thioredoxin helps prevent cardiac hypertrophy
In the November 3 issue of the Journal of Clinica... increased oxidative stress and stimulates cardiac hypertrophy
via redox-sensitive mechanisms when the animal is at rest and also when subjected to pressure overlo...
JCI Table of Contents, September 15, 2003
...org/press/18816.pdf HATs off to Hop in cardiac hypertrophy
Histone acetylation, regulated by two antagonisti...ssor homeodomain-only protein (Hop) causes cardiac hypertrophy
via recruitment of a class I HDAC. In contrast to the body of work on transcriptional mechanisms tha...
Experimental cancer drugs may halt events that lead to cardiac hypertrophy and heart failure
...rsity of Pennsylvania School of Medicine. Cardiac hypertrophy
is one of the leading causes of congestive heart f...s for and new therapeutic agents against cardiac hypertrophy
and heart failure. Furthermore, the researchers demonstrate that anti-HDAC drugs can block the devel...
JCI Table of Contents
...death, they do not develop significant ventricular hypertrophy
(ventricle enlargement), suggesting that a distinct cellular mechanism apart from alterations in myocardial contractility is responsible. A new study by Jil Tardiff and colleagues at the Albert Einstein College of Medicine in New York has revealed th...
New study provides first linkage of fetal alcohol exposure and enlarged heart
... removed) in order to determine if the ventricular hypertrophy
found in female offspring of alcohol-consuming mot...D-2 expression and eliminated the left ventricular hypertrophy
of adult female offspring. Conclusions These data suggest that alcohol-induced changes in placen...
Natural hormone could reverse heart damage
...del of obesity that also develops left ventricular hypertrophy
(LVH), a condition in which the main pumping chamber of the heart expands and stiffens, preventing proper blood flow to the body. Hypertrophy, which results from stress on the heart (for example, through high blood pressure or obesity), starts off a...
JCI table of contents, 2 June, 2003
...c receptors are required for physiological cardiac hypertrophy
in the double-knockout mouse. AUTHOR CONTACT: Paul C. Simpson San Francisco Veterans Affairs Medical Center, San Francisco, California, USA. Phone: (415) 221-4810 x3200 Fax: (415) 750-6950 E-mail: email@example.com View the PDF of this article at: ...
JCI table of contents, May 15, 2003
...apoptosis without compensatory ventricular myocyte hypertrophy
AUTHOR CONTACT: Junichi Sadoshima New Jersey Medi...ww.the-jci.org/press/15496.pdf At the heart of hypertrophy
TITLE: Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of...
JCI Table of Contents, May 1, 2003
...g/press/18526.pdf Pressure-independent cardiac hypertrophy
in mice withcardiomyocyte-restricted inactivation of the atrial natriuretic peptidereceptor guanylyl cyclase-A AUTHOR CONTACT: Michaela Kuhn University of Muenster, Muenster, Germany. Phone : 49-251-83-52597 Fax : 49-251-83-55501 E-mail: mkuhn@uni-...
Study says: 'whey' to greater muscle strength is through training and protein supplements
...e responsible for maximal force production and the hypertrophy
(growth) response to resistance training. The most interesting finding from this research was that a highly significant (P<0.001) correlation between the magnitude of strength gained in three weight lifting exercises assessed and the increase in ...
Are we mice or men? Gene mutation linked to improving heart failure in mice proves lethal in humans
...r,the effect of inhibiting PLN in cases of cardiac hypertrophy
(which canprogress to heart failure) was unknown. ...ertrophy in which mice destined to develop cardiac hypertrophy
were alsogenetically modified to lack the PLN gene. They found that the absence ofthe PLN gene resto...
A decade later, gene discovered by Temple researchers found to be multi-functional
...ed that cdk9 can be used to block life-threatening hypertrophy
or enlargement of the heart. Their study was published in the November 2002 issue of Nature Medicine ( www.nature.com/cgi-taf/DynaPage.taf?file=/nm/journal/v8/n11/abs/nm778.html ). An immunologic role for cdk9 has also been discovered and was ...
Gene could hold key to predicting, combating life-threatening abnormal heart growth
...heart becomes enlarged a condition called cardiac hypertrophy
when it responds to stresses, including irregular...ctrical signals that control heart rhythm. Cardiac hypertrophy
frequently is a cause of sudden death among young athletes, who suffer cardiac arrest due to enlarge...
Transgenic mice mimic cardiac hypertrophy in humans
...reated a new strain of mouse that exhibits cardiac hypertrophy
an enlargement of the heart similar to that which...ibit sex differences in the development of cardiac hypertrophy
similar to those in humans. The male mice develop enlarged hearts but the females do not. However, w...