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AAAS US Presidential Candidates' Forum

***Those who cannot attend the AAAS U.S. Presidential Candidates' Forum in person may listen to a live audio webcast at ......On September 30, the American Association for the Advancement of Science (AAAS), will host a special Candidates' Forum on...

US Presidential Candidates' Forum

WASHINGTON, DC - On September 30, AAAS will...host a special Candidates' Forum on Science &...Technology Policy, at which representatives...of the U.S. presidential campaigns of...incumbent George W. Bush and challenger John...Kerry will discuss their plans and policies...for science and technology. ......The Forum will take place in the AAAS Auditorium, ...12th and H Streets, N.W., Washington, D...

Rutgers chemist uses NMR to elucidate protein-DNA interaction

NEWARK — Determining exactly how proteins connect with specific DNA sequences in human cells has eluded researchers and scientists for years. While it has been possible to record the speed at which a protein could bond with DNA, little was known about how proteins located and connected with a specific pattern of DNA to allow genes to express themselves in the form of traits such as facial ap...

The search for a safer smallpox vaccine: New data released on promising candidate

ST. LOUIS -- When used as an aerosolized weapon, smallpox could be controlled by a new vaccine under study at Saint Louis University School of Medicine, according to new data.... ...Detailed results from studies by Dr. Mark Buller of Saint Louis University School of Medicine were presented at the Seventh Annual Conference on Vaccine Research, sponsored by the National Foundation for Infectious D...

Tigecycline - Candidate antibiotic produces 74 percent cure rate in cSSSI patients

... ...Oklahoma City, OK An antibiotic, currently being tested in clinical trials, produced a 74 percent cure rate for hospitalized patients with possibly life-threatening, complicated skin and skin structure infections (cSSSI). Tigecycline, a candidate antibiotic drug, produced these promising results in a study led by Russell G. Postier, M.D., OU Physicians Chairman of Surgery and John A....

Annotation marathon validates 21,037 human genes

The announcement of the human genome sequence three years ago was widely hailed as one of the great scientific achievements in modern history. But sequencing the genome is just a first step -- the monumental task of ascribing biological meaning to those sequences has just begun. The H-Invitational international consortium, led by Takashi Gojobori (Tokyo, Japan) has taken a significant step toward...

ESA consults European science community on candidate Earth Explorer missions

The six candidate missions for Earth Explorer, part of ESA's Living Planet programme, are: ...... EarthCARE Earth Clouds Aerosols and Radiation Explorer to improve the representation and understanding of the Earth's radiative balance in climate and numerical weather forecast models by acquiring vertical profiles of clouds and aerosols, as well as the radiances at the top of the atmosphere. Fro...

VaxGen reports Phase I clinical trial results of anthrax vaccine candidate

BRISBANE, Calif. - March 2, 2004 - VaxGen, Inc. (Nasdaq: VXGN) today announced results of its Phase I trial of recombinant Protective Antigen anthrax vaccine, rPA102, at the International Conference on Emerging Infectious Diseases (ICEID) in Atlanta, Georgia. The double-blind, multi-center study, which began in June 2003, was designed to examine the safety and immune response of a range of doses...

Oxidation processes basis of interdisciplinary research, graduate training

(Blacksburg, Va.) Virginia Tech chemists are using the oxidation process to create polymers from fats. Virginia Tech food scientists try to block or slow oxidation to prevent foods from spoiling. Researchers in human nutrition, foods, and exercise, and veterinary medicine are interested in how oxidative stress is related to obesity and Type II diabetes in animals and humans. These scientists are...

GAD2 as a candidate gene for obesity

Like many complex physiological conditions, obesity results from the interaction of multiple genes and environmental factors. In a large case-control study of nuclear families in France, Philippe Froguel and colleagues used genome-wide scans of a chromosomal region linked with susceptibility to hone in on a new candidate gene for obesity. The same group had previously found strong linkage between...

Sleep deprivation within five hours of learning impairs memory consolidation in mice

PHILADELPHIA -- Scientists at the University of Pennsylvania have found new support for the age-old advice to "sleep on it." Mice allowed to sleep after being trained remembered what they had learned far better than those deprived of sleep for several hours afterward.... ...The researchers also determined that the five hours following learning are crucial for memory consolidation; mice deprived...

Researchers identify fatty-acid oxidation as additional source of nutrients in the placenta

DALLAS June 2, 2003 Researchers at UT Southwestern Medical Center at Dallas have helped discover that an expectant mother's placenta nourishes her fetus by oxidizing fatty acids in addition to providing the developing fetus with glucose previously believed to be the placenta's only energy source....... The findings will appear in the June issue of the American Journal of Physiology-Endocrinolo...

UCLA biologists elucidate fertilization process

UCLA graduate student Jeffrey Riffell and UCLA biology professor Richard Zimmer report the first experimental test on the role of small-scale physics as it influences the interactions between sperm and egg, and the consequences for fertilization, at the annual conference of the Association for Chemoreception Sciences in Sarasota, Fla., April 10. ......The physics of fluid motion has a profound co...

New study validates criteria for safe, rapid treatment of patients with cocaine-related chest pain

DALLAS Feb. 6, 2003 - Close observation and testing of patients with cocaine-related chest pain in the first 12 hours after diagnosis is sufficient to safely determine the risk of heart complications, according to a researcher at UT Southwestern Medical Center at Dallas.... ...The findings, published in today's New England Journal of Medicine, will help emergency departments develop standardized...

Researchers elucidate machinery of major anti-cancer target

DURHAM, N.C. -- Duke University Medical Center biochemists have reported the detailed function of an enzyme that is a key component of a signaling pathway important for about 30 percent of cancers. Their surprising findings about how the enzyme, called farnesyl transferase (FTase), works could help improve the FTase-inhibiting drugs that pharmaceutical companies are now testing to fight a broad s...

Researchers identify candidate vaccine for Sjgren syndrome

TORONTO - Researchers at The Hospital for Sick Children (HSC), Toronto Western Hospital and the University of Toronto (U of T) have identified the protein that triggers the autoimmune response in Sjgren syndrome, a prevalent autoimmune disease, as well as a candidate vaccine to treat this condition. This research is reported in the October 5 issue of the scientific journal The Lancet....... Using...

Jackson researchers identify a gene implicated in oxidative stress and neurodegeneration

Oxidative stress is implicated in a fast-growing list of human conditions, from the superficial (e.g., wrinkled skin) to the deadly: diseases such as cancer, heart disease and neurodegenerative disorders including Lou Gehrig's disease (amyotrophic lateral sclerosis or ALS). ...Researchers at The Jackson Laboratory announced that they have located a gene that protects certain brain and retinal neu...

Promising multi-strain HIV vaccine candidate emerges

BALTIMORE, Md.--AIDS researchers have developed a candidate vaccine strategy that, for the first time, demonstrates an ability to elicit antibodies that block the infection of multiple HIV virus strains -- an elusive scientific goal that has been pursued for a decade. ... ... The candidate vaccine - still early in developmental stages at the Institute of Human Virology (IHV) -- is described in a...

Ten new candidate genes associated with salt sensitivity and hypertension are identified in rats

New Orleans, LA -- The cause of most hypertension is unknown, thus, there is no cure. Worldwide control rates are poor, and less than one-fifth of the 500 million affected people have their pressures adequately controlled through treatment.... ...Background ...Dietary salt intake is one of the most important environmental determinants of human hypertension. In as many as one third of hypertensiv...

Candidate genes found which may play a role in cancer progressing from non-invasive to invasive

Scientists in America have made the first steps in identifying a group of genes which may be involved in the progression of breast cancer from non-invasive to invasive, the 3rd European Breast Cancer Conference in Barcelona heard today (Thursday 21 March).... ...Professor Craig Allred, Director of Breast Pathology at the Breast Center, Baylor College of Medicine, Houston, USA, used a technique ca...

Adult human breast stem cell candidate found

An international collaboration of scientists has successfully established a cell line that appears to function like adult human mammary stem cells. The report appears in the March 15th issue of the research journal Genes & Development....... Whereas embryonic stem cells are the building blocks for all of the cell types in the body, adult stem cells are a more specialized type of progenitor cell...

Oxidative damage to eNOS by tissue peroxynitrite

The peroxynitrite anion (ONOO-) is blamed for chemically modifying a variety of proteins and lipid species under conditions of inflammation and oxidative stress. Building on their present studies of the peroxynitrite's effects on the endothelial NO synthase (eNOS), Zou et al. propose a biochemical pathway by which such damage can be propagated in vascular tissue. eNOS and the other NOS's are mor...

Genetica, Inc. develops high throughput RNAi tool for drug target validation

Cambridge, MA, January 29, 2002 The biotechnology company Genetica, Inc has developed a powerful, high throughput tool for target validation in the drug discovery process based on research carried out by scientists at Cold Spring Harbor Laboratory. The research, published today in the Proceedings of the National Academy of Sciences (PNAS), demonstrates stable suppression of gene expression in ma...

Cyclin B1 identified as a new tumor antigen and candidate for the development of a cancer vaccine

PITTSBURGH, Nov. 5 Results from a study published in the November issue of the Journal of Experimental Medicine, and featured on the journals cover, demonstrate that the protein cyclin B1 is a newly identified tumor antigen that holds promise as a candidate for the development of a cancer vaccine. The new antigen will be used in future cancer vaccine trials for breast cancer, lung cancer and hea...

Male infertility: Scientists discover candidate gene for impaired spermatogenesis

Lausanne, Switzerland: Researchers in the Netherlands believe they have identified a gene that is involved in causing infertility in men....... Dr Judith Gianotten told the European Society of Human Reproduction and Embryology annual meeting in Lausanne today (Wednesday 4 July) that the ZNF214 gene is probably a candidate gene for impaired spermatogenesis (an inability to make enough sperm cells...

New proteomics tool offers a clear look at cellular proteins IDAT can detect proteins at an unprecedented resolution for research and clinical use

.(Philadelphia PA) Scientists may have identified the genes in the human genome, but proteomics is the growing field of research that describes how proteins encoded in those genes work. Researchers at the University of Pennsylvania School of Medicine have created the first new technology for the proteomic era, a technique sensitive enough to detect individual proteins and robust enough to scree...

Potent new compound from blue-green algae may help treat, elucidate nerve disorders

. . Click for abstract.. . HONOLULU, Dec. 19 - Amid a growing list of biologically useful chemicals from the sea, a newly discovered compound - kalkitoxin - stands out for its potential to help researchers understand nerve function, which could someday lead to new treatments for pain, epilepsy and possibly stroke. The finding was reported here today at the 2000 International Chemical Cong...

Researchers find candidate gene for premature menopause

.Researchers from New Zealand have identified a gene which may be .implicated in premature menopause, also known as premature ovarian .failure (POF)*, a condition affecting one in a hundred women under .the age of 40 and one in a thousand under the age of 30.. .Women as young as teenagers can suffer this distressing condition .and although some retain a measure of ovarian function and even .beco...

Heart failure patients with worst heart function are good candidates for pacemakers

.The pacemaker has taken on an increasingly important role in recent years. Originally used to fix electrical abnormalities in people with irregular heart rhythms, it is now in favor for heart failure patients as a way to "resynchronize" a weak and struggling heart.. .In a study of 22 patients, Johns Hopkins researchers have found that those whose hearts have the largest amount of timing discor...

UI researcher validates underpinnings of scientific theory

. IOWA CITY, Iowa -- A University of Iowa researcher and his colleague have confirmed that researchers studying the evolution of ancient marine life, while overlooking much relevant data, have the record straight.. . That's important, according to Jonathan Adrain, assistant professor in the UI department of geoscience, and Stephen Westrop of the University of Oklahoma, because such data provide...

Breakdown of penicillin by resistant bacteria elucidated

. Almost as soon as penicillin was discovered, more than 70 years ago, certain bacteria had learned how to resist this common antibiotic. These resistant bacteria make beta-lactamase, an enzyme that quickly breaks down penicillin. Now, seven decades later, scientists at the University of Chicago led by Marvin W. Makinen, Ph.D., professor of biochemistry & molecular biology, have discovered exa...

Chiron reports on discovery of novel men B vaccine candidates based on whole genome sequencing of Neisseria meningitidis by TIGR

Emeryville, CA, March 9, 2000 -- Chiron Corporation (Nasdaq: CHIR) today announced that its research team located in Siena, together with collaborators at The Institute for Genomics Research (TIGR) in Rockville, Maryland, and the University of Oxford, have determined the complete genome sequence for Neisseria meningitidis, the bacterium primarily responsible for meningococcal disease. Chiron als...

Scientists discover new candidate drugs for treating HIV infection

.Scientists have achieved a major step toward finding a new class of oral drugs.to treat HIV infection. They have identified a class of compounds that prevent.HIV infection by stopping the virus at its port of entry into the cell. Unlike.currently used drugs that target HIV at other points during its life cycle--after.it has already infected the cell--these compounds lock into a vulnerable "po...

Enzyme Required To Prolong Life In Worms Identified By Researchers At Columbia; Key Enzyme Appears To Protect Animal Cells From Oxidative Damage

. Researchers at Columbia University have discovered an enzyme that is.required to prolong the life span of microscopic roundworms and that strains of.long-lived worms appear to produce in greater quantity than normal.. . They believe the enzyme, called cytosolic catalase, protects cells from.oxidative damage, considered a key element in the aging process in all animals,.including...

UCSD And NIH Researchers Isolate Candidates For Genetic Basis Of Human Taste

.A collaborative effort between Howard Hughes Medical Institute researchers at.the University of California, San Diego and scientists at the National Institute.of Dental and Craniofacial Research (NIDCR), National Institutes of Health.(NIH), have identified the genes likely responsible for the mammalian sense of.taste.. .In the Feb. 19 issue of the scientific journal Cell, the researchers descri...

Antioxidant Vitamin Supplementation And Lipid Peroxidation In Smokers

.Previous studies have shown that cigarette smoke enhances lipid peroxidation. This study examined the effect of daily consumption of a tomato-based juice supplemented with vitamin C (600 mg), vitamin E (400 IU, or 400 mg), and b-carotene (30 mg) on various indexes of lipid peroxidation (breath pentane excretion and susceptibility of LDL to copper-mediated oxidation) in smokers. In addition, pla...

Team Of Max Planck Scientists Elucidates Structure Of A Protein Segment Involved In 'Von Recklinghausen Neurofibromatosis'

..Scientists at the Max Planck Institute for. Molecular Physiology in Dortmund and of the Max Planck. Institute for Medical Research in Heidelberg (Germany) have. determined the first structure of a functional protein unit. that is involved in the development of ‘von. Recklinghausen neurofibromatosis’. This unit is a. regulator of another protein involved in the patho...

New Tuberculosis Vaccine Candidate Developed: Improved Delivery Of Antigens By Current Vaccine BCG (Bacille Calmette-Gurin)

Scientists at the Max Planck Institute for Infection Biology, Berlin and at the University. Clinics of Ulm have developed a putative vaccine candidate against Mycobacterium. tuberculosis, the causative agent of tuberculosis. Their data have been published in the. Proceedings of the National Academy of Sciences U.S.A. on April 28, 1998. . . Although tuberculosis belongs t...

Candidate Regulator Of The Temporal Component Of Neurotransmitter Release Identified

In a joint effort, the groups of Heinrich Betz from the. Max Planck Institute for Brain Research (Frankfurt, Germany). and George Augustine from the Duke University (Durham, NC). have tested the hypothesis that NSF, a ubiquitous protein. required for a variety of general membrane fusion and. secretion events in eukaryotic cells, is also involved in. neurotransmitter release at...

Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease

.DURHAM, N.C. -- Researchers at Duke University Medical Center have identified.a gene in mice that, when malfunctioning, causes a joint-destroying, arthritis-like.disease in the animals. The discovery may provide a clue to the underlying.genetic defects that can lead some people's immune systems to attack their.own bodies, the Duke researchers say. . . Led by Dr. Perry Blackshear of the Howard...
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