New drug shows promise against Gleevec resistance in mice
...lem of Gleevec (imatinib) resistance. "The identification of this compound as a drug candidate is a direct b... issue of the journal Cancer Cell , reporting the identification of 15 mutations in the BCR-ABL gene that caused resistance to Gleevec. In that paper, Kuriya...National Corn Growers Association announces valuable maize genome data now available to scientists
...he public domain will significantly accelerate the identification of genes within the entire corn genome. This project underscores NCGA's continued commitment to advancements through research. NCGA took a leading role in getting the Plant Genome Initiative signed into law in 1997 and continues to support this impo...Gene profiles could improve acute leukemia diagnosis and lead to better treatments
...AML, which occurs at a much higher incidence. The identification of AML subtype signatures is important because the outlook for a particular patient depends on whether he or she has the subtype that is favorable, intermediate or unfavorable, according to James Downing, M.D., chair of the St. Jude department of Pat...New research suggests previously unrecognized mechanism by which blood vessels are patterned
...angement of blood vessels (patterning). "With the identification of this receptor, we hope to one day develop molecular medicines that will essentially steer developing blood vessels away from where they shouldn't go," said Epstein. This finding - published in the July 2004 issue of Developmental Cell - may lay t...Genetic mutation found that is major contributor to type 1 diabetes
...nity, we have guessed right a few times, including identification of HLA. But this is the first time we have used a systematic approach to find the gene and it's the first gene in which we know how it contributes to the disease." For example, HLA is a regulator of immunity that has been known for 30 years, but res...Plant pathologists look to forensics to aid in biosecurity
...plication of forensic science to assist in precise identification of microbes and their origin. "If a plant disease ...to effectively manage a disease outbreak, requires identification of a disease agent (pathogen) that is accurate to species or strain. Species-level identification is...Summer in the South: Kudzu and oriental bittersweet
...st damage to Southern forests. Along with detailed identification guides, the book provides general control information and specific prescriptions for individual plants. Contact: James Miller Research Ecologist jmiller01@fs.fed.us 334-826-8700 Copies of the guide are available free at www.srs.fs.us...UCSD team determines cellular stress within body is critical
...way would represent an exciting new target for the identification of anticancer drugs." In describing his team's research, Ho said that it was previously thought that the kidney was the only tissue in the body that was subject to osmotic stress. The kidney controls how much water and salt is in our blood using a m...JCI table of contents, 1 July 2004
... Half at the Wrong Time Creates Bad Blood The identification of a genetic mechanism that underlies one form of thrombocytopenia, may provide new understanding of other completely unrelated diseases.Thrombocytopenias are bleeding disorders that occur world-wide and can become life-threatening situations where a...In the obese, metabolic adaptations post-weight loss lead to regaining of shed pounds
...posed to the development of obesity. Even if such identification was possible, it would be difficult to follow them throughout the protracted course of the development, treatment, and recurrence of their obese state. Rats offer a better opportunity to address this issue. The ability to select obesity-prone rats,...Innovative efforts target epigenetics, molecular imaging
...o list is the development of technologies to speed identification of epigenetic marks and their locations across the entire human genome - to essentially create a map of the "epigenome." Next, in collaboration with researchers from Pennsylvania State University in University Park, Pa.; Epigenomics, Inc., of Berlin;...Hopkins to found first center for comprehensive study of epigenetics
...' to-do list is development of technology to speed identification of epigenetic marks and their locations in the genome and then adapt these methods to examine multiple sections of the genome and many samples at once. Next, with Johns Hopkins colleagues and collaborators from a German company called Epigenomics, t...Brain development and puberty may be key factors in learning disorders
...h learning difficulties," said Wright. "With early identification of children with language-related learning disabilities, we may be able to remediate many of these problems by 'training' a child's brain very early in life." ...JGI, VBI help unravel sudden oak death & soybean disease
...s, the genome sequence information will enable the identification of cellular processes that can be targeted for nov...amorum genome represents the fastest tracking from identification of a new plant pathogen to the completion of its genome," says Dr. Brett Tyler of VBI. Tyler's resea...Virginia Bioinformatics Institute researcher advances fight against sudden oak death disease
...e represents the fastest tracking time between the identification of a complex pathogen (in 2000) and the completion of its genome (in 2004). Tyler, along with representatives from the Department of Energy Joint Genome Institute (JGI at www.jgi.doe.gov), United States Department of Agriculture (USDA), USDA Forest S...Memory fails you after severe stress
...al photos- though the clothing cue boosted correct identification to 66 per cent (International Journal of Law and Psychiatry, vol 27, p 265). Thirty people got the gender wrong, and those subjected to physical threats were the worst at recognising their interrogator. Elizabeth Loftus, a psychologist at the Univer...NIH launches first center in Nationwide Chemical Genomics Network
...liest stages of the drug development pipeline: the identification of useful biological targets. This is a win-win situation for basic biology, for the drug industry and, most importantly, for the American public." Christopher P. Austin, M.D., who is NHGRI's senior advisor for translational research, will direct the...Thimerosal, found in childhood vaccines, can increase the risk of autism-like damage in mice
...ased brain size. These findings have relevance for identification of autism cases relating to environmental factors; design of treatment strategies; and development of rational immunization programs. The use of thimerosal in vaccines has been reduced over the past few years, although it is still present in some in...Common worm provides insights into salmonella virulence
...thogenesis remain unknown," he said. "But with the identification of the targeted pathways in the host, we should be able to figure out how virulence factors influence the innate immune response." Aballay said that the C elegans system could be an effective living model for testing or screening new compounds or dru...... Diagnostics new approaches to infectious disease identification Biomaterials and Tissue Engineering novel materials for cartilage repair, collagen technologies, biopolymers. Bioprocessing and Functional Foods - production of high value chemicals for the food, pharmaceutical and other industries Bioi...