Tag: "immunocompromised" at biology news

New advance to combat antibiotic-resistant pneumonia and malaria

...ated opportunistic infection and a threat to other immunocompromised patients, such as those undergoing therapy for cancer and organ transplantation. Pneumonia was responsible for more than 61,000 deaths in the US in 2001, according to the National Center for Health Statistics. Appearing in the January 23 Journal ...

Tips from the Journals of the American Society for Microbiology

...robiology. "Children under the age of 10 years and immunocompromised people seem to be especially prone to infections with reptile-associated Salmonella spp. and often experience severe clinical courses, including fatalities due to septicemia and meningitis." In the study, fecal samples were collected from pet snakes ...

Results of pivotal study for GlaxoSmithKline's Valtrex published in New England Journal of Medicine

...sion of genital herpes has not been established in immunocompromised individuals or same-sex couples. In August 2003, the U.S. Food and Drug Administration (FDA) approved a supplemental new drug application (sNDA) for VALTREX tablets for suppressive therapy in otherwise healthy adults with genital herpes in order to r...

JCI table of contents, December 15 2003

...a with high mortality, almost exclusively afflicts immunocompromised patients despite intervention with antifungal agents. Molecules known as chemokine ligands are essential in recruiting white blood cells (WBCs) to sites of infection. In order to better understand the role of the immune response in aspergillosis, Bor...

Breakthroughs lead to better understanding in prevention of transfusion-transmitted infection

... affect healthy individuals but may seriously hurt immunocompromised patients, who often receive donated blood. Severa...TT-CMV) infections occur in up to three percent of immunocompromised patients, despite the use of CMV seronegative (antibody negative) and filtered blood components. Cy...

JCI table of contents, 15 October, 2003

...d and poses a particular threat to the elderly and immunocompromised patients such as those with HIV or organ transplan...a of research, vaccination may not be effective in immunocompromised individuals. Therefore it is conceivable that this group of individuals may benefit from passive the...

Pathogenic yeasts and fungi: A growing health concern

...nt in systemic infections because we have a larger immunocompromised patient population," says Robert T. Wheeler, a pos...entation, Saccharomyces has appeared more often in immunocompromised patients, raising several questions about its origin, survival and virulence in humans. In their st...

Horse owners should vaccinate horses, experts say

...ons usually cause only mild illnesses. Elderly and immunocompromised people are at increased risk of severe infection. There is no vaccine yet for humans. UC Davis mosquito-control experts also recommend controlling mosquitoes around horses (and homes) by removing unnecessary standing water, repairing leaking faucets ...

Stem cells put to the test in UNC studies

...Center, said the rat stem cells were injected into immunocompromised mice to avoid rejection. The cells had been genetically engineered to contain a "transgene" that confers resistance to a cell-killing drug and "marker" transgenes (beta galactosidase and green fluorescent protein) that allow detection by their color....

Scientists discover role for Cdk4 in making cells cancer resistant

...ir ability to form solid tumors when injected into immunocompromised mice). The researchers found that while Cdk4-deficient cells grow and divide normally under standard conditions, once the Ras oncogene is activated, these cells retreat into a cancer-resistant state of terminal growth arrest, called senescence. Ras-e...

Tips from the Journals of the American Society for Microbiology

...or treatment of human cytomegalovirus retinitis in immunocompromised patients, is potentially a good candidate for the treatment of a poxvirus outbreak, in the absence of any vaccination," say the researchers. (R. Snoeck, A. Holy, C. Dewolf-peeters, J. Van Den Oord, E. De Clercq, and G. Andrei. 2002. Antivaccinia ac...

Scientists discover role for c-myc gene in tumor angiogenesis

... cells have a diminished ability to form tumors in immunocompromised mice, and that the small tumors that sometimes form have dramatically less vasculature. Further delineation of role of c-Myc in promoting human tumorigenesis is needed, but as it stands, this study presents strong evidence to suggest that the disrupt...

Unraveling the genetics behind melanoma and colon cancer

...capable of forming tumors when injected into live, immunocompromised mice. Dr. Ben-Ze'ev and colleagues also found that Nr-CAM is highly expressed in human melanoma cells and colon cancer tissue. These multiple lines of evidence strongly suggest that Nr-CAM is a novel b- and g-catenin target gene whose expression con...

Immune system component found common to both humans and worms

...ilar. To do that, they looked for worms that were immunocompromised or extra-susceptible to pathogens. They identified two genetic mutations associated with this susceptibility in genes that are part of a signaling pathway also known to be involved in the innate immune response of humans. "Because it's the only kn...

Stanford study finds potential shingles prevention in a childhood vaccine

... bacteria," said Arvin. "The idea that they are so immunocompromised that you can't benefit these patients by vaccination during the early stage of the transplant is incorrect." Researchers suspect that the protection against shingles is conferred by memory T cells - virus-specific immune cells jump-started by the v...

Adult human breast stem cell candidate found

...n culture, as is the cell line when implanted into immunocompromised mice. Of particular interest to the researchers was the finding that these cells also express the keratin K19 protein, a characteristic shared with a subpopulation of luminal epithelial cells in the normal breast. This work suggests that the long ...

Protein mix-up tied to suppressed immune response early in HIV infection

...for a long time is why some people with HIV become immunocompromised before you would think they should; that is, while they still have significant numbers of CD4 and CD8 T cells," said senior study author Dr. Jeffrey A. Frelinger, Kenan Professor and chair of microbiology and immunology at the University of North Car...

Dartmouth researchers expose weakness of common parasite

...in infected people, but can be life threatening in immunocompromised patients and cause severe birth defects in newborn...athogens Cryptosporidium parvum, also a danger for immunocompromised patients, and Plasmodium falciparum, a cause of virulent malaria that kills more than 2 million chil...

Fighting Fungi

... tissues and produces fatal systemic infections in immunocompromised people. Under nitrogen-poor conditions, each of these fungi switch to filament form and thus become pathogenic. This physiological response to nutrient availability has been well documented. It is only now beginning to be understood. Schrder and coll...

Biologists find Peruvian plants inhibit growth of TB bacterium

...most threatening resurgent disease today among the immunocompromised and immunocompetent, and the need for new drugs is paramount," Lewis states in the journal article. Fortunately, the exposure of TB in the remote parts of the Upper Amazon has been minimal, and the native tribes, including the Aguaruna, have little e...

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