Tag: "immunological" at biology news

JCI table of contents, January 2, 2004

...lymphocytes (CTLs) kill target cells by forming an immunological synapse with these cells. The CTLs and target cells adhere using the adhesion molecules LFA-1 and its counter-receptor ICAM-1. In the January 2 issue of the Journal of Clinical Investigation, Michael Dustin and colleagues from the Skirball Institute ...

Scientists develop a novel strategy to help prevent transplant rejection

...n with extensive efforts to find the best possible immunological match between donor and recipient, organ transplantation resigns the recipient to a lifetime of powerful immunosuppressive drugs that have many unwanted side effects. "Increasingly organ transplants in the case of kidneys, liver or lung tissue occur ...

JCI Table of Contents, November 3, 2003

...by the addition of doxycycline (DOX). A cascade of immunological events including lymphocyte activation, lymphokine production, and proliferation of synovial cells (which comprise the loose connective tissue lining the joint cavity) is associated with collagen-induced arthritis in mice. Mountz and colleagues found...

FDA approves Raptiva (efalizumab) for chronic moderate-to-severe plaque psoriasis

...iopharmaceuticals for disease targets that include immunological and inflammatory disorders, cancer and infectious diseases. XOMA's programs include collaborations: with Genentech, Inc. on the RAPTIVA TM antibody for psoriasis (FDA approval), psoriatic arthritis (Phase II) and other indications; and with Millenni...

Retroviral protein triggers proliferation of immune cells

...ocytes (PBMCs). Jurkat cells are commonly used for immunological studies, while PBMCs contain HTLV-1's normal target cell. Copies of the p12 gene were transferred into both cell types. Then the genes were activated as they would be during HTLV-1 infection, causing the cells to produce p12 and IL-2. After several ...

Fourteen Grand Challenges in Global Health announced

...for effective, protective immunity. 6. Learn which immunological responses provide protective immunity. Control in...rapies that can cure latent infections. 12. Create immunological methods that can cure chronic infections. Measure disease and health status accurately and economic...

Cow's resistance to worms is genetically determined

...tection of eggs in the animals' excreta. Secondly, immunological parameters were used to confirm the three groups of animals. In an animal that has no resistance to a worm infection, the worms occur in the first part of the small intestine. In animals that develop resistance, worms are translocated towards the end...

New vaccines may address need to protect newborns in the developing world

...ey might be able to address an important window of immunological vulnerability in the lives of infant children. Par...at the chimpanzee adenovirus vaccine possesses the immunological advantages of a human adenovirus vaccine, but without the drawbacks of likely pre-existing immunity ...

Researchers solve the mystery of a key structure in immune system cells

...ich sticks them together. This region is called an immunological synapse, since it resembles the synapses that form...oncentration effect, it was first thought that the immunological synapse served to simply amplify signals between cells. But the team found in previous experiments t...

Women are more likely to suffer recurrent miscarriages if their first child is a boy

... suffer from SRMs. "These women may have raised an immunological reaction against tissue types that are expressed o...iological study, so we cannot be sure that such an immunological reaction is the explanation for our findings. However, no genetic disorder following the known rules...

'Immortalized' cells enable researchers to grow human arteries

... the goal is to engineer arteries that will resist immunological attack, so they must be grown from cells taken from the actual patients who will ultimately receive the arteries. To create the arteries, the researchers fashioned a tube from a thin sheet of a biodegradable polymer, which, like a sponge, is 97 perce...

Mouse model offers new explanation for kidney disease and failure

...n response to infection. The researchers found no immunological abnormalities in these mice that could account for the antibody accumulation. By injecting a tracer that allowed them to watch as proteins moved through the blood into the kidney, they found evidence that CD2AP functions to route proteins for degrada...

In some patients with chronic fatigue syndrome, left ventricular function may be involved

...vent. Unfortunately, efforts to find infectious or immunological causes have not been successful. Growing evidence, however, points to a possible problem with circulation. Previously reported findings include autonomic dysfunction, lower plasma volume and/or red call mass, as well as abnormalities in neurohormonal...

Phase III study results with Raptiva in the treatment of psoriasis presented at Annual AAD meeting

...ceuticals for disease targets that include cancer, immunological and inflammatory disorders, and infectious diseases. XOMA's programs include collaborations: with Genentech, Inc. on the Raptiva TM antibody for psoriasis (BLA submission), rheumatoid arthritis (Phase II), psoriatic arthritis (Phase II) and other in...

Results from open-label Raptiva study suggest continued benefit with long-term treatment

...ceuticals for disease targets that include cancer, immunological and inflammatory disorders, and infectious diseases. XOMA's programs include collaborations: with Genentech, Inc. on the Raptiva TM antibody for psoriasis (BLA submission), rheumatoid arthritis (Phase II), psoriatic arthritis (Phase II) and other in...

Richard A. Lerner and Peter G. Schultz to receive Paul Ehrlich and Ludwig Darmstaedter Prize 2003

...riate reaction by using its binding energy. Using immunological methods, Lerner and Schultz generated antibodies against molecules containing phosphate and phosphonate groups. They resemble the activated transition states in their three-dimensional structure, such as in ester hydrolysis. The new antibodies were s...

Allergen-free shrimp? seafood marks a place in food safety research

... to Lehrer, who is in the process of developing an immunological test, with mice, to check foods for allergenicity. Work on altering animal-based allergens is generally much less further along than that for plant-based food allergens, for which breeding programs and food processing have been used to address allerg...

Targeted immunotherapy eradicates cancer in mice

...t the cells could not successfully carry out other immunological responses such as maintaining cell division, and would die prematurely when they were infused into the body of a mouse. In this study, researchers may have overcome some of these limitations by designing a method whereby human T cells, genetically al...

Fighting fire with fire? Vaccine based on chimp virus shows promise against HIV

...he new chimpanzee adenovirus vaccine possesses the immunological strengths of a human adenovirus vaccine without the drawback of pre-existing immunity in its target population. Because HIV infects only humans and chimpanzees, the current study used a sophisticated mouse model to test the new vaccine. For this mode...

Emory Vaccine Research Center study identifies specific gene required for long-term immunity

...tion. People with SAP mutations often present with immunological abnormalities and chronic infections. Many of the deaths among people with X-linked lymphoproliferative disease result from infection with Epstein-Barr virus. The VRC study suggests that this may be due to the inability of SAP-negative individuals to...

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