UCLA/Caltech scientists develop new gene therapy approach
...plications for treating infectious, autoimmune and immunological diseases. "We can apply siRNAs to prevent a micro-organism from entering the body or appearing in the wrong place at the wrong time," Baltimore said. "We can also shut down excess production of a particular hormone. The possibilities are endless."...Prize to Weizmann Institute professor for landmark work in stem cell transplantation
...em cell transplant requires that only three of six immunological markers be matched. Such a match is always present between parents and children, and there is a 75% chance of finding it among siblings. If the search includes the extended family, more than 95% of patients can find a donor. The achievements of the P...Jewels that may help explain behavioral disorders found among 'junk' DNA
...ervous system to control automatic, behavioral and immunological responses of stress. Alterations in CRH neural activity appear to contribute to a number of mental illnesses including depression, anxiety disorders and anorexia nervosa. In addition, the CRH smnRNA appears to form a complimentary match with a sequen...UC Davis to begin identifying eligible families for study on environmental factors in autism
...h and Disease Prevention is studying molecular and immunological mechanisms underlying neurodevelopmental disorders involving studies in animals and cell systems and of specimens from the children in the CHARGE study. Pessah, principal investigator for the Center for Children's Environmental Health and Disease Pre...Scientists discover ancient protein and DNA sequences in the same fossil
...ne formation. The researchers demonstrate, using immunological data, that osteocalcin remains in bones heated to high temperatures (165oC) for several hours and is measurable in bones that are around 120,000 years old, emphasising the survivability of the protein. According to Nielsen-Marsh, "The research has t...UCSF-led team reports new test improves detection of prions in animals
... with chronic wasting disease (CWD). The test, an immunological probe, or "immunoassay," uses a novel strategy and...protein than can be seen with the current standard immunological procedures. Those older methods, which detect only fragments of infectious prion protein that are re...Shadow proteins in thymus - Clues to how immune system works?
...proteins in the thymus, which is why we call it an immunological self-shadow," said Mathis. In a critical step, the Joslin team discovered that the transcription factor aire plays a critical role in producing these self-shadow proteins in the thymus (hence its name, which is formed from two letters in each word o...Scientists, researchers, animal advocates & regulators to discuss alternatives to animal testing
...ess in the production of polyclonal antibodies (an immunological technique which involves animals). The HSUS will also bestow the 2002 Russell and Burch Award to a scientist who has made an outstanding contribution towards the advancement of alternative methods, at an awards ceremony on Wednesday, August 14. Past ...Heart-felt stress can be more dangerous to immune system
...lar reactors can be differentiated on the basis of immunological changes. Interestingly, it is only cardiac responders that show a significant redistribution of lymphocytes in response to stress," Farag says....Genome Therapeutics, University of Southampton and Schering-Plough identify novel asthma gene
...thma susceptibility. Rather than the allergic and immunological components that contribute to asthma, these genetic analyses suggest that ADAM33 is involved in the generation of bronchial hyperresponsiveness (BHR). The association of this gene with BHR and possible links with airway remodeling offers new avenues...1st evidence that nuclear transplantation ('therapeutic cloning') can eliminate tissue rejection
...s not only survived and functioned as kidneys, but immunological studies carried out both in the transplanted animals and in the laboratory confirmed that there was no rejection response to the cloned tissues. "This was a study to investigate how the immune system would deal with cloned tissue in an animal model...LSU researcher studies the effect of viral infection on allergic airway diseases in horses
...led allergens. The current study hopes to identify immunological events that lead to the allergic response in the affected horses....UNC, other physicians setting up national registry
...east one biotechnology company is working on a new immunological approach designed to shut down the bodys production of the abnormal antibodies. ......parently normal early development. Most reports of immunological abnormalities in autistic children have been from this subgroup of affected children, and the authors cite the increasing body of evidence for abnormal immune regulation and autoimmunity in autism. The initial observation of unexpected bowel patholog...UM Cancer researchers test custom-made vaccine for non-Hodgkin's lymphoma
..., about two-thirds of the patients showed positive immunological responses to the vaccinations. But it is difficult to know the clinical impact of that, he says. Does it mean that they have better responses or longer-lasting responses? Thats what this study is designed to show. In this trial, patients ...UPCI presents study on dendritic cells in prostate cancer
...dendritic cells. Our data may explain the strong immunological non-responsiveness that we often see in patients with advanced prostate cancer, said Michael Shurin, M.D., Ph.D., associate professor of pathology at the University of Pittsburgh and associate director of clinical immunopathology. For the first time,...Multimillion dollar immunology research directed at edible or nasally delivered vaccines
...production of protective antibodies. Adjuvants are immunological agents that increase the antigenic response. UVa will study the mechanisms of regulation of mucosal immune responses. VCU will apply genomics and informatics technology to discover potential targets for intervention through immunotherapy or chemothe...Chimpanzee virus may be key to better vaccines, study shows
...ine based on a chimpanzee adenovirus possesses the immunological strengths of a human adenovirus vaccine without its drawbacks. The study appears in the March issue of the Journal of Virology. "The chimpanzee adenovirus vaccine works like a charm," says Hildegund C.J. Ertl, M.D., a professor at The Wistar Institut...Virulence molecules found for poultry bursal virus
...used wasting away of the bursa, which is the major immunological organ of chickens, but did not cause the hemorrhaging condition and high death rates of earlier, so-called classic, strains found in the United States in the 1960's. However in the 1990's, strains of IBDV emerged in Europe and Asia that killed up to ......riticism and debate largely because the underlying immunological mechanisms of the human body are still unknown and because there has been no way of controlling the contents of the allergen-containing extracts. To boost their immune response to an allergen, patients suffering severe allergic responses are usuall...