Low-Protein Diet May Reverse Kidney Disease
...ontrast with other treatments, such as steroids or immunosuppressive drugs, the dietary treatment, though often difficult for patients to follow, has no side effects, says Walser. The diet excluded such high-protein foods as meat, fish, poultry, cheese and milk and included supplemental tablets of amino acids, the bui...Duke researchers find existing drugs can stop fungus that attacks AIDS patients
...nd kidney disease. The researchers found the immunosuppressive drugs cyclosporin and FK506,which are used to trea...uriziodel Poeta, Perfect and Heitman showed a non- immunosuppressive drug in thesame family as cyclosporin and FK506 also blocks the fungus from growingat body temperatu...Gene Therapy Enables Transplantation Without Immunosuppressive Drugs
...edorgans are potentially significant. The powerful immunosuppressive drugs nowrequired to allow a life-saving transplan...m liver engraftment without the needfor continuing immunosuppressive drug therapy. "What we have developed is a feasible model for a gene therapy approachto loca...Transplanted Neurons Restore Function In Rats After Stroke
...-Neurons intothe brains of rats. In rats receiving immunosuppressive drugs to control graftrejection, function was restored and maintained for more than six monthsfollowing transplantation. "The hNT-Neurons were just as beneficial as fetal brain cells alone inimproving movement and behavioral recovery," observ...15 Drugs, Dyes And Other Chemicals Newly Listed As Known Or Likely Human Carcinogens
...sted as known human carcinogens: CYCLOSPORIN, an immunosuppressive drug. THIOTEPA, a drug used to treat lymphomas and tumors of the breast andovary. It has also been used at high doses in combination chemotherapywith cyclophosphamide in patients with refractory malignancies treatedwith autologous bone transplantatio...Novel anti-cancer agent shows minimal side effects with preliminary evidence of tumor shrinkage
...ctivity. CCI-779 is a derivative of rapamycin, an immunosuppressive agent. Results were presented at the International Conference on Molecular Cancer Therapeutics - Discovery, Development, and Clinical Validation, sponsored by the American Association of Cancer Research (AACR), the National Cancer Institute (NCI) an......old's research results might help to develop novel immunosuppressive agents. Dr. Andreas Gansäuer (33), University of Freiburg, Institute for Organic Chemistry Andreas Gansuer is working in the field of organic synthesis. In recent years radical reactions have increasingly been used in this area, while the search...ZymoGenetics discovers potential new therapy for autoimmune diseases
...r autoimmune diseases . Administration of a novel immunosuppressive agent developed at ZymoGenetics inhibited disease ...esulting in kidney damage and sometimes death. The immunosuppressive agent under investigation at ZymoGenetics, termed soluble "TACI," is a modified form of a receptor t......en species without rejection or the need for toxic immunosuppressive drugs," added Dr. Flake. Collaborating with Dr. Flake in the study was Kenneth W. Liechty, M.D., of Childrens Hospital. Other co-authors were from Childrens Hospital and from Osiris Therapeutics of Baltimore, Maryland, a biotechnology company....Searching for the secrets of drug-free transplants
...roup of transplant patients who are completely off immunosuppressive drugs to see if clues can yield simple laboratory ...y, a life-long regimen of anti-rejection drugs, or immunosuppressive drugs, is required to prevent the transplanted organ from being attacked by the patient's immune sys...Adult stem cell therapy for heart failure proves promising
... system, thus there would be no need for expensive immunosuppressive drugs, says Chiu. The technique, which other research teams are investigating for treating diseases affecting several organs, emerged from decades of basic research. "In the classic view of science, bone marrow had only one function - to replace re...Dr. Thomas Starzl receiving prestigious King Faisal International prize this week in Saudi Arabia
...ty of Pittsburgh in 1981, Dr. Starzl pioneered the immunosuppressive agent tacrolimus, resulting in significant improve...on behalf of the university. "His contributions to immunosuppressive techniques, organ procurement, organ preservation, tissue matching, surgical technique and the team ...... their CNS-directedT cells, which express the same immunosuppressive transgene and are effective against a different autoim-munedisease, do not persist in the synovium and fail to suppress arthritis. In a complementary effort, Morita et al.show that dendritic cells (DCs), which control the proliferation and immunologi...Intrakine blockade of a chemokine receptor
...trakine strategy for treating AIDS may prove to be immunosuppressive in its own right....Nature's chemical weapons save lives
...o's group for seven years. Its novel structure and immunosuppressive activity drew the group's interest. "Immunosuppres...of pateamine A to this protein is the basis of its immunosuppressive effects. They also hope to find compounds that have increased chemical stability and potentially in...Dendritic cell-based vaccination to prevent opportunistic fungal infections
...ion of CD4+ T cells, AIDS patients and others with immunosuppressive conditions are in a poor position to mount a protective response to vaccines. The absence of T cell help is particularly troublesome because of the opportunistic infections that are common among these patients. Noting that CD4+ cell-independent immun...Animal study finds embryonic stem cells can repair heart muscle
...ents, the majority of whom are too sick to receive immunosuppressive drugs. "There's a 1 percent incidence of CHF among the population at large, and that figure rises to 10 percent among elderly patients," says Morgan, adding that approximately half of these cases result from heart attacks. "A new therapy that could r...Knocking out SHIP gene improves success of allogeneic bone marrow transplants in mice
...raft-versus-host disease is largely treatable, the immunosuppressive drugs administered for it create serious side effects for patients. In fact, graft-versus-host disease and its consequences remain the number one cause of death following transplant. Bone marrow transplant rejection is rare when the person donating t...Antioxidant vitamins may help transplant patients
... antioxidants did not appear to interfere with the immunosuppressive drugs the patients needed to take, or cause any increase in transplant rejection. Some past studies looking at this and other issues had used vitamin E, by itself, as a supplement, and failed to improve patients' outcomes, the study said. The use......oomberg School of Public Health. Measles is a very immunosuppressive virus. It results in many secondary infections and is a major cause of death among children. Our findings show that measles also triggers intense immune system activation that temporarily suppresses HIV, explains Dr. Moss. For the study, Dr. Moss and...