Children's Hospital Boston researchers use therapeutic cloning to create functional tissue in cows
...ation of "non-self" tissues, and thus the need for immunosuppressive drugs, which carry the risk of serious and potentially life-threatening complications and enormous cost to the United States health care system. In the study, researchers obtained cow oocytes (donor eggs from cow ovaries) and removed and discarded th...Antioxidant protects islet cells used in transplants for diabetes
...o produce their own insulin. Patients have to take immunosuppressive drugs to prevent rejection of the transplants, but they maintain better control of their insulin levels, thus reducing the chances of future complications. They also avoid the daily insulin injections. Clinical trials of the "Edmonton protocol" are b...Transplant patients from 40 years ago cause Pittsburgh doctors to take an about-face
...volving pre-transplant T cell depletion and single immunosuppressive therapy following transplantation, John J. Fung, M.D., Ph.D., Thomas E. Starzl Professor of Transplantation Surgery, said 14 have been able to be actively weaned. Many are on substantially lower weekly doses than other liver transplant patients not t...Islet cell transplantation for diabetes turns corner
...eceived a mixture of pig cells, without the use of immunosuppressive drugs and without her immune system attacking the ...n the ages of 11 and 17 and did not administer any immunosuppressive drugs to protect the cells from being rejected. Six of the 12 patients have functioning grafts, and ...Bone marrow donor cells present in muscle fibers of boy with MD years after transplant
...'s father. The team followed up the treatment with immunosuppressive drugs to prevent rejection of the transplanted bon...lem to the after-effects of the transplant and the immunosuppressive drugs given for it. During a regular check-up when the boy was 12, however, Weinberg's team realized...Rare disorder provides new insight into fighting infection
...ful target for a new class of anti-inflammatory or immunosuppressive therapies." The NIAID scientists were called on to examine a brother and sister with a puzzling immune system disorder. "These kids were very sick, and their doctors were stymied about the cause of their illness and how to treat it," says Dr. Lenardo...Genetic findings in monkey herpes virus could aid research in human cancer
...you're HIV-infected or a transplant patient taking immunosuppressive drugs or a patient undergoing chemotherapy, you are more likely to develop Kaposi's sarcoma. In sub-Saharan Africa, many children 6 years of age develop Kaposi's with very bad lesions. It's the number one childhood cancer in this region primarily as ...Zengen, Inc. announces novel approach to reduce organ rejection
...erimental heart transplantation, in the absence of immunosuppressive therapies. Donor cardiac grafts (Brown Norway) were transplanted into the abdomen of recipient (Lewis) rats. Treatments consisted of intraperitoneal injections of the a-MSH peptide or saline from the time of transplantation until sacrifice or spont...Chicken pox vaccine OK for children with kidney disease
...ndergo a kidney transplant. After transplantation, immunosuppressive medications put these children at high risk for severe chicken pox complications, including pneumonia, brain inflammation, and death. "We recommend pediatric nephrologists include chicken pox vaccination as an important component of pre-end-stage re...Receptor could be target for cancer therapy
... the EP2 receptor is a key mediator of the tumor's immunosuppressive action," said Richard M. Breyer, Ph.D., associate professor of Medicine and Pharmacology. The team of investigators, including Breyer, Dr. David P. Carbone, Ingram Professor of Cancer Research at the Vanderbilt-Ingram Cancer Center, and graduate stud...Stem cells: From bone marrow to pancreas
...ber of diabetic patients, and the side effectsfrom immunosuppressive drugs that transplantation patients have to take aresevere. Scientists have therefore looked for other sources of beta cells,specifically for stem cells that could be expanded and induced to becomebeta cells. Mouse embryonic stem cells can develop in...Baylor researchers show way to diabetes cure with gene therapy
...as, because it avoids the lifelong use of powerful immunosuppressive drugs and eliminates the need to find a compatible donor. Chan credits one of his postdoctoral students, Dr. Hideto Kojima, with much of the work in developing this protocol....Brookhaven Lab & Battelle collaborate on research that may lead to novel anti-microbial drugs
... those with cancer or AIDS, or patients undergoing immunosuppressive therapies for organ transplantation or for the treatment of diseases such as multiple sclerosis and psoriasis. As a first step in reaching this goal of developing new drugs, Brookhaven biologist Maria Bewley will use the National Synchrotron Light So...Islet cells from swine reverse insulin dependency in diabetic non-human primates
...glucose levels. Researchers used combinations of immunosuppressive therapies to allow the cells to function within th...rsity of Minnesota. "For this study, we looked at immunosuppressive regimens that were well tolerated in past monkey-to-monkey islet transplants. The survival times we ...JCI table of contents, 16 June 2003
...due in large part to the availability of effective immunosuppressive drugs. Such drugs are designed to sufficiently suppress the recipient immune response to the donor tissue without compromising the ability to fight infection. In the 50 years since the first description of tolerance to transplanted tissue in mice, re...Donor cells from new source ignored by the immune system
...lant recipients typically receive massive doses of immunosuppressive drugs in the hope of buying time for grafted cell or organ to survive and take hold. Pig umbilical cord matrix cells appear to be ignored by the immune system when implanted into rat brain, which makes the cells potentially useful as future therapy. ...Brain stem cells are not rejected when transplanted
...ay eliminatethe need for tissue typing before, and immunosuppressive drugs after,transplantation. Ultimately these findings promise to improve the success ofretinal transplantation to regenerate vision for millions with maculardegeneration, retinitis pigmentosa and diabetic retinopathy and braintransplants to restore ...Small subset of cells has big role in controlling immunity, study finds
.... They have shown that giving mice an experimental immunosuppressive agent causes a select number of these cells to exp...he immune system. "In principal we can use the new immunosuppressive drug to do that. We can treat mice with the reagent, and introduce antigens that their immune system...JCI table of contents, 15 October, 2003
...with HIV or organ transplant recipients undergoing immunosuppressive drug therapy. Using a mouse model of histoplasmosis, Joshua Nosanchuk and colleagues from Albert Einstein College of Medicine in New York have identified monoclonal antibodies that targeted the histone H2B-like protein of H. capsulatum and reduced fu...FDA approves Raptiva (efalizumab) for chronic moderate-to-severe plaque psoriasis
...atment due to acute adverse events. RAPTIVA is an immunosuppressive agent and has the potential to increase the risk o...on and reactivate latent, chronic infections. Many immunosuppressive agents have the potential to increase the risk of malignancy. The role of RAPTIVA in the development...