Virus linked to Kaposi's sarcoma sabotages immune system with a new and unusual strategy
...to search for additional viral proteins that might impair host immunity in other ways. Until the advent of modern antiretroviral therapies for AIDS, Kaposi's sarcoma was the most common cancer of AIDS patients. Therapies that now control the AIDS virus have also controlled KS, Ganem pointed out, because a...What happens when genetic information is not correctly edited in brain cells
...ain and many peripheral tissues. They succeeded to impair ADAR2-mediated editing by genetic manipulation in the mouse. Now, the proteins were composed as specified exactly by the nucleotide sequence on the gene. The Heidelberg team show in the Nature study that mice making unedited gene transcripts become p...Low frequency EMF damages mice ovarian follicles
...results raise concerns that ELF-EMF exposure might impair female reproductive potential by reducing the capacity of follicles to reach the developmental stage that is an essential prerequisite for successful reproduction." People are exposed to ELF-EMF daily in the home or at work through power lines an......ental design of anti-fungal therapies. Drugs which impair protein folding or otherwise activate the UPR may serve as models in the search for new anti-fungal agents....Ovarian stimulation in mice adversely affects embryo development and implantation
...s by hormone drugs to produce more eggs appears to impair both the development of the embryo and its likelihood of implanting in the uterus. Dr Gudvor Ertzeid and Dr Ritsa Storeng from The National Hospital, University of Oslo, Norway, undertook the study to establish whether impaired embryo quality or chan...Genome project opens the book on human evolution
...s into genes would be deleterious, that they would impair the protein's ability to function," said Li. "Instead we find a surprisingly large number in translated proteins." The repetitive elements seem to insert into non-coding regions of a gene and be incorporated into protein through alternative splicing...Rat study shows high-fat diet impairs concentration and memory
...et can interfere with glucose use in the brain and impair cognitive function, then glucose injections would result in improved cognitive performance. If this were the case, they also wanted to determine if the glucose-enhanced performance was general in nature or specific to certain types of brain function....Brain gene implicated in autism
...no acid composition of the WNT2 protein, and could impair the functioning of proteins and downstream biological pathways involved in brain development. The researchers also produced evidence for the existence of a more common WNT2 variant that may be involved in more cases of autism. A nucleotide sequen...... in the production of more aggregates that further impair the proteasome. The relatively slow buildup of aggregates in and around nerve cells could explain the latency of many neurodegenerative diseases, adds Kopito. The effects of aggregate formation can remain silent for a long time until aggregates build...Science researchers report 'extremely unstable' gene expression in cloned mice
...erentiation into different cell types, and doesn't impair the creation of normal mice generated by transplanting these embryonic stem cells into very early stage embryos called blastocysts....Mom was wrong, UCLA/VA researcher concludes sleep not essential for learning
...p by awakening them or by drug treatments does not impair their ability to form long-term memories. In particular, humans taking a class of drugs called MAO inhibitors that eliminate REM sleep for periods of months or years have unimpaired or even improved memory. Humans with brain damage that prevents ...Brain researchers discover bright side of ill-famed molecule
... cholesterol metabolism in the brain may therefore impair its development and function". Pfrieger's results indicate that nerve cells produce enough cholesterol to survive and to grow, but too little to form enough synaptic contacts. Thus, they depend on external sources of this component. Where does the ex...Munching microbes aid environment, oil industry
...onmental impact, including pollutants that kill or impair fish and aquatic organisms, cause health problems through contaminated water, fish or shellfish, and degrade aquatic ecosystems. EPA guidelines regulate how and how much water-based and petroleum-based fluids can be discharged into the water, but unt...Cell interactions in spermatocyte apoptosis
...ortunate effects, heavy metals such as cadmium can impair male fertility. Whether oligospermia arises from environmental exposure to cadmium is unclear from epidemiological studies, but male rats treated with this metal reliably decrease their production of mature sperm. Ozawa et al. have found that this re...Undergraduate unraveling genetic mysteries in fruit flies
... can distort the shape of the developing gland and impair its ability to move into proper position within the growing embryo. Comeaux received a Provosts Undergraduate Research Award that allowed her to continue working in Andrews lab last summer. She assisted Pamela L. Bradley, now a postdoctoral fellow,...Anticonvulsant drugs found to impact on epileptic childrens ability to recall information
...leans -- Epilepsy and its treatment have proven to impair cognitive and behavioral functions. The impact on the former by epilepsy associated seizures, brain damage, and use of anticonvulsant drugs can result in memory deficits, attention problems, and reading and writing difficulties. About two million ...Rad50 and the maintenance of genome stability
...ge in the protein. This mutation had been shown to impair Rad50 function in yeast. The scientists quickly discovered, though, that this subtle change at the amino acid level of Rad50 had serious, and unexpected, consequences for the organism. The Rad50-mutant mice displayed partial embryonic lethality, with...Researchers identify candidate vaccine for Sjgren syndrome
..., others suffer debilitating symptoms that greatly impair their quality of life. There is currently no effective therapy for Sjgren syndrome. By removing the gene that produces the ICA69 protein, mice that normally develop Sjgren syndrome had no tear gland disease and a much reduced salival disease. In the ......not life-threatening, vascular disease can greatly impair the health and productivity of patients, he said. For example, of the 500,000 who suffer strokes each year, only 10 percent recover fully. Thirty percent die within one year and 60 percent survive, but suffer from ongoing disability. The total cost t...