Infants more vulnerable to serious brain injury from falling than previously thought
...r brain function, and nerve cell damage, which can impair thinking, sensation, and other mental functions. Infant falls are often dismissed as relatively benign because the head is assumed to be moving in a straight line at impact, Margulies said. Linear motions are associated with such localized injuries ...Stem cell defects are key to Hirschsprung's disease
...sprung's disease act in neural crest stem cells to impair their ability to form a normal intestinal nervous system," Morrison adds. Neural crest stem cells are one variety of tissue or "adult" stem cells. Unlike embryonic stem cells, which can become nearly any cell in the body, NCSCs normally develop into...JCI Table of Contents, 15 August 2003
...tivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance AUTHOR CONTACT: Bernard C. Rossier Institut de Pharmacologie et de Toxicologie, Lausanne, Switzerland. Phone: 41-21-692-5351 Fax: 41-21-692-5355 E-mail: bernard.rossier@ipharm.unil.ch View the PDF of this article at: ......nly predispose the vasculature to disease but also impair compensatory adaptations to various stimuli including shear force and injury. Other studies have demonstrated a progressive increase in oxidative stress, activation of inflammatory mediators, and increasing endothelial dysfunction in both humans and ...New vaccines may address need to protect newborns in the developing world
...lizing antibodies circulating in the blood able to impair any vaccine based on a common human adenovirus. In essence, many people would be prevented by their own immune systems from realizing the benefits of a vaccine based on a human adenovirus. For this reason, the researchers developed a version of the v...Mutant gene linked to obsessive compulsive disorder
...by repetitive unwanted thoughts and behaviors that impair daily life. "In all of molecular medicine, there are few known instances where two variants within one gene have been found to alter the expression and regulation of the gene in a way that appears associated with symptoms of a disorder," said co-aut...RSRF-funded study leads to breakthrough for Rett Syndrome research
...theorize that in Rett patients, mutations in MeCP2 impair its ability to regulate BDNF, and that BDNF's subsequent over-expression may cause Rett symptoms. However, Greenberg points out that BDNF is only one of approximately 300 genes that are controlled by neuronal activity, some of which may also be MeCP2...Study offers new insight into Rett Syndrome
... Researchers suspect that mutations in the protein impair its ability to regulate genes during a critical st...gests is that in Rett patients, mutations in MeCP2 impair its ability to regulate BDNF, and that BDNF's subsequent over-expression may cause Rett. However, Gr...Calcium channel involved in coronary artery relaxation
...l contraction. Losing this channel did not seem to impair blood vessel contraction. This result is somewhat surprising because calcium influx through calcium channels is known to cause muscle contraction. However, when the researchers treated blood vessels from the genetically altered mice with a vasodilato...Gene mutation leads to super-virulent strain of TB
...rchers expected that mutating the mce1 genes would impair the pathogen's ability to infect the mice. Instead, the bacteria became more deadly. "This is one of the very few hypervirulent organisms ever created," said Lisa Morici, a lead author of the study who received her Ph.D. in infectious diseases fr...New findings bring mixed blessings to those looking to combat jet lag
...sleep disturbances and daytime sleepiness, and can impair performance after landing. A team of researchers has investigated the effects of slow release caffeine (SRC) and melatonin (Mlt) on recovery sleep and daytime sleepiness after a seven-time zone eastbound flight and found that both drugs have positive...Toxin combo common in fish appears capable of impairing motor skills
...d suggested that the two chemicals act together to impair nervous system function. A study in February's issue of the Journal of Pediatrics found that exposure to methylmercury causes heart damage and impairs brain growth. The new study -- pursued as part of the doctoral dissertation by Schantz's...Scientist works to interrupt early changes resulting in diabetic vision loss
...the NMDA receptor. Additionally, high glucose may impair other transporters found on supportive cells such as retinal Muller cells, which help eliminate unnecessary or even harmful substances in and around cells. Muller cells, for example, can take up glutamate and convert it to harmless glutamine, so Dr. ...Research on inherited eye disorders uncovers new information about blood-vessel formation
... a modest abnormality of vasculature that does not impair vision at all to a severity of scarring that eliminates vision completely," said Nathans. FEVR is known to arise from defects in a gene known as Frizzled-4 , which codes for a protein receptor (Fz4). Although Nathans and his colleagues had studied t......alth because they disrupt the hormonal balance and impair reproduction and development. What has not been clear up to now is the amount of phthalates that enter the human body. The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is funding a research project at the University of Erlangen-N...Gladstone study reveals how genetic factor may increase risk for Alzheimer's disease
...apoE4 is broken down into toxic fragments that can impair the function and survival of nerve cells. Results of their study may point the way to a new therapeutic strategy for the prevention and treatment of Alzheimer's disease. ApoE4 is the best known genetic risk factor for Alzheimer's disease, but, until ...Animal studies show promise treating severe chronic pain
...vity level, and other severe side effects that can impair overall quality of life." Based on these data, Iadarola said the RTX technique has tremendous potential in veterinary care. But the group's ultimate goal is to move the treatment into early stage clinical trials in the near future for people with se...Molecular image of genotoxin reveals how bacteria damage human DNA
...nd how to interact with the active site of CdtB to impair its activity, which could give us some ideas for achieving the same thing with a drug molecule," said Stebbins. Armed with an atomic model of a protein, scientists can program computers to screen virtual representations of millions of compounds to se...UNC scientists block cellular enzyme activity involved in cancer progression
...his interaction might reduce activation of FAK and impair aberrant cell motility or survival conferred by FAK under pathological conditions, such as cancer."...... migrating, however, sleep deprivation appeared to impair their performance - similar to what happens to sleep-deprived humans. If researchers ascertain how the birds do so well on so little sleep during migration, the finding could benefit people who need to stay awake and function at a high level for long...