New gene monitors cell division, cancer clinical applications seen
... to drugs in this class. So, a diagnostic test for inactivated chfr might be used to predict the responsiveness of a patient's cancer to Taxol® or a related drug, allowing doctors to give their best drug at the start of therapy. Our findings could also be useful in developing new drugs that might be more eff...Tumor cells made more sensitive to radiation by blocking a key cellular molecule
...sor molecule when ferried into tumor cells via an inactivated cold virus creates a very stable attachment to NF-kappaB. "We were able to determine that NF-kappaB inhibition by either method did in fact produce increased cell killing after radiation," Tepper said. "And we could document both increased cell killi...... HIV-1 Immunogen (known as Remune), is a disabled, inactivated form of HIV. It was administered in small doses t... of a specific compound developed from a disabled, inactivated form of HIV.The trial involved 2,527 HIV-infected patients at 77 medical centers in the United State...Scientists find infection history must play key role in vaccine development
...ave protected them from the harmful effects of the inactivated RSV vaccine. The younger children became quite ill and some died. The data may explain age related differences to vaccination. For instance, you would expect new-born babies to have experienced fewer infections than an adult and therefore you canno...Cloning can turn back the developmental clock
...tion as normal females do or the same X chromosome inactivated in all her cells (the X that was inactive in the m... cells were dark or fluorescent green, which X was inactivated and when. The researchers then created various populations of donor cells with known X-inactivation ...Biological warfare: an emerging threat in the 21st century
...s until they fall to the ground, where most become inactivated by sunlight,`` Block writes. ``Anthrax is not very communicable,`` he adds, ``thereby reducing the risk that it will spread beyond the intended target. Moreover, a well-established vaccine exists that can prevent the onset of the disease, allowing it......o acids, which, despite its relatively small size, inactivated C3 entirely. Lambris named the molecule Compstatin. "Since C3 was so large, we assumed that we would find many different fragments that would bind to C3, and from them we would learn more about the important functional parts of the molecule,"said La...UNC to test virus treatment for recurrent head and neck cancer
...ant head and neck tumors are made of cells with an inactivated p53 gene. Cancer cells are the only cells in the body in which p53 has been inactivated allowing for specific killing of cancer cells by the modified virus." Adenovirus with a mutated or d...Quick, easy, color-coded technique will speed identification of drugs for diseases
...and other proteins. Researchers have known that an inactivated GPCR holds onto three G-protein pieces (alpha, beta and gamma) that dangle into the interior of the cell. When a molecule activates and binds to a receptor's "docking bay" on the outside of the cell, the receptor causes the three pieces to drift apar...UCSD researchers create a home for liver cells on a silicon chip
...that can be activated to perform their function or inactivated and then eliminated from the body. In general, the metabolism of a drug by the liver will dictate its clinical value. Bhatia says that by introducing various drugs onto the bioreactor, she can test how the substances are detoxified by the liver cel...Fast controlling axis specification
...muel Lunenfeld Research Institute in Toronto, have inactivated the FoxH1 gene in mice. As published in G&D, both groups found that the lack of functional FoxH1 had a profound effect on axis specification. In many cases, the developing mouse embryos could not specify the anteriorposterior axis. In some cases, the...E. coli bacteria may be more useful than you think
...ns firmly attached to the surface of the cell. The inactivated phage particle becomes a perfect support on which to bind cargo. The protein that encloses the head of the phage can be engineered to bind tightly to the vitamin biotin. Streptavidin, a protein that interacts strongly with biotin, can then be attach...Structural studies reveal how potassium channels are inactivated
...nt binding -- that is, they may bind better to the inactivated state than to the non-inactivated state, he said. So if we know the conformational changes between these different states with different binding affinities, we can design better drugs that will bind to particular states and thereby modulate the chann...New study tightens the link between smoking and early menopause
...ouse models, Tillys team also found that eggs with inactivated Ahr or Bax genes were resistant to PAH-induced death, indicating the functional importance of these two players in premature ovarian failure resulting from exposure to these toxic chemicals. To demonstrate the relevance of their findings to humans, ...UNC study pinpoints gene crucial for female embryo survival
...'s not been understood what maintains this X in an inactivated state. Now we know that eed plays a role in this process," said Magnuson. "Without eed functioning normally, the father's X chromosome is shut down and then it comes back on. When that happens, too many X chromosome genes are active, there are pro...New model of staph drug resistance implicates unlikely protein
...le for PBP2 to aid in resistance while still being inactivated by the antibiotic. Beta-lactam antibiotics are known to inactivate PBPs by binding to the peptide-linking region of the protein, hence the sugar-linking region remains free to cooperate in the resistance mechanism. The findings indicate that the suga...Gene therapy technique reduces alcohol consumption in rats
...ora Volkow, Ph.D., and colleagues used a partially inactivated virus as a vector, or transport agent, to carry copies of the DRD2 gene to the rat nucleus accumbens, the brain area associated with the reinforcing effects of alcohol. Supplying copies of the gene in this manner enables the rat brain cells to manufa...CNS cell death in bacterial meningitis
... forms pores in animal cell membranes. The authors inactivated both of these factors, first by using bacterial strains with specific mutations that block their production, and second by adding exogenous inhibitors. Simultaneous inhibition of pneumolysin and peroxide protects the cells from bacteria-induced killi...Other highlights in the Jan. 16 issue of JNCI
...ole in pancreatic cancer because its expression is inactivated in more than 90% of pancreatic cancers. These two proteins are interdependent; pRB expression is inhibited by p16, and p16 expression is inhibited by pRB. Thomas Plath, Stefan Rosewicz, M.D., and colleagues at Humboldt University, Berlin, tested whet......one in a careless manner, whereas in cells with an inactivated Rad54 gene this figure was about 80%. The results ...lphalan, mitomycin C or cisplatin. The researchers inactivated the Snm1 gene in mice. After this the mice were given a small quantity of mitomycin. Mice with a ina...