Tag: "inappropriate" at biology news

Genetic discovery in fruit flies may open new avenues for understanding cancer growth in humans

...es, it leads to death," Parkhurst said. In humans, inappropriate gene silencing is thought to account for various sex-linked genetic disorders, in which the affected genes are located on the X chromosome. Such developmental abnormalities, which nearly always affect males, include xeroderma pigmentosum (a rare, inh...

Research suggests diabetes drug being prescribed even when contraindicated

...studies in Europe that documented similar rates of inappropriate metformin prescribing, said Dr. Cheryl Horlen, who conducted the research as a pharmacy resident at UNC. We are concerned that these patients may be at risk of a serious medical condition known as lactic acidosis, which can be life-threatening. In th...

Men regain evolutionary drivers seat

...d a wrong gene genealogy," Makova says. "Also, its inappropriate to use closely related species because of ancient-nucleotide polymorphism." This means at the time of speciation, there already were mutations accumulating on chromosome 3. But the Y chromosome, which had virtually no polymorphism, did not start accu...

Movement without senses coded into neurons, says University of Toronto researcher

... embryos hatched from their shells, they exhibited inappropriate movement such as moving backwards, swinging their heads frequently and crawling upside down. This strongly suggests that sensory information plays a crucial role in directional movement and that without such information, animals are unable to adapt t...

Breaking the silence: Discovery could lead to new treatments for cancer, sickle-cell anemia

...l of which have genetic abnormalities that lead to inappropriate silencing of genes that are critical for healthy growth. The finding appears in the Dec. 18 edition of the Proceedings of the National Academy of Sciences.The authors of the paper are Antonio Bedalov, M.D., Ph.D., a research associate in the Clinical...

Controlled nerve growth factor aids brain cell transplant

...s survival and axonal growth, and they can promote inappropriate growth among other tissue. We needed to create a local delivery system to ensure activity within the microenvironment of the brain, where the transplanted tissue should thrive, without side effects." Mahoney and Saltzman expanded on a technique the...

New study tightens the link between smoking and early menopause

...fined the actual molecular mechanism that triggers inappropriate death of eggs after exposure to PAHs. We need to get people away from thinking that toxic chemicals cause general harm. Here we have mapped how a chemical, through several discrete steps, influences specific genetic events that lead to cell death, ...

UCSD researchers decipher molecular "code" capable of controlling plant water loss during droughts

...ey can tune in to appropriate stimuli and tune out inappropriate stimuli. The guard cells can read the oscillations and modify their behavior. If the calcium oscillations are either too fast or too slow, the guard cells can sense that and the stomata will open up again." Plant scientists have for more than a deca...

Scientists decipher "fail-safe" system that limits gene copying in cells

...al potential ways the cell machinery might prevent inappropriate re-replication, but we were repeatedly frustrated in attempts to show that any of them were actually involved," said Joachim Li, PhD, UCSF assistant professor of microbiology and immunology and senior author on the Nature paper. "We would experimenta...

More extensive analysis casts doubt on portion of the public project's human genome paper

...the authors of the human genome paper are based on inappropriate scientific assumptions and are likely incorrect." In the TIGR study, researchers found just 41 genes that are exclusively shared by humans and bacteria, rather than the 223 cited in the original report. These 41 genes, they argue, could all have been...

Leptospirosis raising health concern among companion animal owners

...e days, treat it with the wrong antibiotic or with inappropriate fluid therapy, it can create irreversible renal failure," Harkin said. Humans are also at risk for contracting leptospirosis. Symptoms can be relatively mild and include flu-like symptoms, ocular pain, redness of the eyes, nasal discharge, fever, or ...

Johns Hopkins experts launch Palm OS version of digital antibiotics and infectious disease guide for physicians

...dress concerns over antibiotic drug resistance and inappropriate drug prescribing, the ABX Guide is the first in a planned series of easily navigated, up-to-date digital specialty handbooks from Hopkins medical experts. Instead of relying on quickly outdated and limited paper versions of drug references, ABX Gui...

UC Davis M.I.N.D. Institute launches new program to identify biomarkers for autism and other disorders

...ay range from exposure to environmental toxins, to inappropriate responses to childhood vaccinations or to food allergies. "If we are able to predict which children are threatened by specific life events, we can take special precautions to limit their exposures," said Amaral. "We could also begin therapeutic int...

Researchers discover new mechanism of drug that alters genetic makeup of viruses

...us polymerase incorporated ribavirin into the RNA, inappropriate genetic base-pairings occurred. Instead of the viral RNA pairing together in typical C-G or G-C and A-U or U-A combinations, it produced altered, or "mutant," combinations as it copied its RNA genome. Because ribavirin actually changed the structur...

UI researchers investigate regulation of immune system memory

...ive vaccinations." Autoimmune diseases result from inappropriate activation of certain T cell subsets, which recognize self-antigens as opposed to pathogen antigens. Understanding how T cells are regulated could also help scientists understand and possibly treat autoimmune conditions....

A genetic basis for attachment disorganization in infants

...ization in infancy has been explained primarily by inappropriate care-giving; our finding suggests a genetic susceptibility to the collapse of organized attachment strategy under stress....

Mutations not the only gene defect that leads to cancer

... genes that would normally prevent inappropriate cell division. In other words, it shuts down one of the body's best mechanisms that prevents a cell from becoming cancerous. "This is the first time in which DNA methylation has been studie...

Bitter taste receptors identified

...ther an essential ability if one is to avoid such inappropriate responses as mistaking a mate for a snack. The organization of the olfactory system reflects this need, with each olfactory neuron expressing only one of the 1,000 or so olfactory receptor genes. Taste is a different matter, especially where bitter...

New research illustrates role of CETP in atherosclerosis

...c program is focused on compounds that inhibit the inappropriate activity of the complementcascade, which is a vital part of the body's immune defense system. The Company is also engaged inthe development of Therapore', a novel system for the delivery of immunotherapeutics for chronic viralinfections and certain ...

New treatment may relieve chronic pain, as reported in the 19 November issue of Science

...mple). The group of neurons responsible for these inappropriate responses transmit electrical signals to each othe... substance P receptors with those that are sending inappropriate pain signals. They can search, for example, for genes that are "turned on" in the misfiring neurons....

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