Study explores gene transfer to modify underlying course of Alzheimer's disease
...dy has been modified in order to decrease risk and increase the potential benefit of NGF. Results from a Ph...proximately 4.5 million Americans. The number will increase as the older segment of the population increases. If there are no significant improvements in treatm...Certain genes boost fish oils' protection against breast cancer
...cts, and the suppression is enhanced by drugs that increase lipid peroxidation. When antioxidants are introduce to battle the effects of peroxidation, though, the cancer continues to grow. "Our findings may have practical implications in treatment and prevention strategies for breast cancer," says Gago-Doming...Scientists explore genome of methane-breathing microbe
...at finding, if confirmed by later experiments, may increase the bacterium's potential as a biotech workhorse. Methanotrophs play an important role in the global energy cycle because they consume methane, a gas that is produced mostly by chemical processes in landfills, in the guts of ruminant livestock such a...Key stimulator of colorectal cancer identified
...tudying polyp formation, PGE2 treatment induced an increase in the number and size of intestinal polyps. Importantly, this effect of PGE2 was not observed in these mice when they lack PPARd. "Our results identify PPARd as a critical downstream mediator in PGE2-stimulated promotion of colorectal tumor growt...Research suggests new avenue for stopping, preventing colon cancer
... PGE2 was given to these mice, "we didn't seen any increase in polyps," DuBois said. "Our results identify PPARdelta as a critical downstream mediator in PGE2-stimulated promotion of colorectal tumor growth," the researchers concluded. A drug that blocks PPARdelta has been developed in France, and the Vand...Prion propagation: Avoiding the toxic oligomer
...observed a pronounced pause, followed by an abrupt increase in polymerization rate. Since the length of the pause showed only a weak dependence on the concentration of monomers, Weissman and colleagues explain, this finding could not be explained by a simple model of nucleation polymerization, in which growth...Targeted therapy knocks out pediatric brain cancer in mice
...stoma as well as reduced cell proliferation and an increase in tumor cell death. Importantly, high doses of HhAntag completely eradicated the tumors, and long-term treatment prolonged medulloblastoma-free survival. No toxic side effects of HhAntag treatment were observed in the mice. The researchers conclu...New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
...(TRAIL), leading to a decrease in cancer cells and increase in the life span of tumor-bearing mice. The study's first author, Jun-Li Luo, M.D., Ph.D., a member of the Karin team in the UCSD Laboratory of Gene Regulation and Signal Transduction, explained that normally, inflammation associated with malignanc...Tips from the Journals of the American Society for Microbiology
...alities of raw-milk cheeses while at the same time increase the levels of undesirable contaminants and foodborne diseases, say researchers from France. They report their findings in the September 2004 issue of the journal Applied and Environmental Microbiology. "Until recently, the bacterial c...USC study links historical increases in life span to lower childhood exposure to infection
...ileen Crimmins firmly link this gradual yet steady increase in human life span to lower childhood rates of exp...e reaching a maximum which would mean that further increase in life expectancy will depend on interventions other than public health such as this new generation...Folic acid vitamin use by women reaches all-time high, March of Dimes survey finds
...r L. Howse, president of the March of Dimes. "The increase is especially important because we've been very wo...ther diets could not be the only reason behind the increase because rates of folic acid use were also higher than expected for women not dieting (39 percent). ...JCI table of contents September 15, 2004
...o a reduction in b cell growth and to an extensive increase in programmed cell death. While PDX-1 is known to be important for pancreatic progenitor cell growth, these studies indicate that it also has a vital role in regulating adult b cell pro-liferation and is a key component of the mechanisms underlying c...Simian virus 40 not associated with non-Hodgkin lymphoma, study shows
...over, epidemiologic studies have failed to find an increase in the risk of NHL among people exposed to SV40-contaminated poliovirus vaccine. To examine the possible association between exposure to SV40 and NHL, Eric A. Engels, M.D., M.P.H., of the National Cancer Institute, and colleagues conducted a populati...Research on carbohydrate metabolism receives historical recognition
... seminal events in the history of chemistry and to increase public awareness of the contributions of chemistry to society. Carl and Gerty Cori, who won the Nobel in Physiology or Medicine in 1947, observed what became known as the "Cori cycle," the process by which the body converts glucose into glycogen,...Molecule awakens and maintains neural connections
...ing neurons. Growth of new dendrites can therefore increase the connection between neurons. Changes in the strength of connections, known as long-term potentiation, allow the brain to create memories. In exploring the growth and development of dendritic spines, Shi, the Jans, and their colleagues first iden...Spontaneous mutation produces new MAO A/B knockout mouse
...re missing in mice, brain neurotransmitters levels increase greatly and body weights are smaller. The mice also show anxiety and aggressive behavior, especially under stress." Looking further into the matter, Dr. Shih determined that a spontaneous mutation in a single nucleic acid base pair in the MAO A gen...New treatment for fibromyalgia
...laces on the body where it hurts to touch--and the increase of pressure pain threshold. Women with or without depression receiving duloxetine benefited emotionally and physically, reporting improvements in general mood, ability to function, and overall enjoyment of life. For the study's 23 men, however, du...K-State's National Agricultural Biosecurity Center receives $1.3 Million from Department of Defense
...mingham will create a series of rotating images to increase awareness of agricultural biopreparedness. The elements will be integrated into an National Agricultural Biosecurity Center portal at K-State, Vanier explained. She said the first objective is to scour the nation's emergency response community for e...New research suggests early diet may play key role in protecting against childhood leukaemia
...sed dramatically during the twentieth century. The increase has mainly affected the under-five age group, in whom the risk increased by more than 50 per cent during the second half of the century alone. Although the causes of leukaemia in children are poorly understood, modern environmental and lifestyle fac...White House to honor UNC School of Medicine scientist for 'early career' achievement
...r-reaching developments in science and technology, increase awareness of careers in science and engineering, recognize the scientific missions of participating agencies, enhance connections between fundamental research and national goals, and highlight the importance of science and technology for the nation's...